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  • 1
    Electronic Resource
    Electronic Resource
    Plasma levels of triamcinolone acetonide as determined by radioimmunoassay after topical application (1977)
    Springer
    Archives of dermatological research 259 (1977), S. 63-70 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine radioimmunologische Methode zur Bestimmung von Triamcinolonacetonid (TAAc) im Plasma beschrieben. Das für diese Methode verwandte Antiserum zeigte hohe Spezifität für TAAc. Die Empfindlichkeit der Methode ging bis 0,2 ng. Der Verlauf der Plasmakonzentrationskurve des TAAc nach intravenöser Injektion in Ratten wurde bestimmt. Die Konzentration des TAAc im Blut der Patienten nach lokaler Anwendung ist sehr gering. Im Blut von ambulanten Patienten wurden keine TAAc-Mengen aufgefunden. Hospitalisierte Patienten zeigten unter TAAc-Plastikokklusionsverband Plasmaspiegel, die sich zwischen 0,8 bis 3,4 ng/ml bewegten. Diese Spiegel blieben konstant für die gesamte Behandlungsdauer.
    Notes: Summary In this paper a method for the radioimmunological determination of triamcinolone acetonide (TAAc) in plasma is described. The antiserum used in the radioimmunological determinations showed high specifity for TAAc; the minimal detectable amount was 0.2 ng. The course of the plasma concentrationtime curve of TAAc after intravenous injection into rats was analysed. The concentration of TAAc in the blood of the patients after topical application of the drug is very low. No detectable amount of TAAc was found in the blood of out-patients. Hospitalized patients treated with TAAc under plastic occlusion showed plasma levels ranging from 0.8 to 3.4 ng/ml. This level remained constant throughout the treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562738
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  • 2
    Electronic Resource
    Electronic Resource
    Blood levels of o,p′-DDD following administration in various vehicles after a single dose and during long-term treatment (1981)
    Springer
    Cancer chemotherapy and pharmacology 7 (1981), S. 51-54 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma levels of o,p′-DDD were measured after ingestion of a single oral dose. At the onset of therapy o,p′-DDD was administered as commercially available tablets and granules and in milk, chocolate, and an oil emulsion to 9, 12, 14, 10, and 6 patients, respectively. Following administration in chocolate, emulsion, and milk significantly higher mean plasma levels were recorded in the first 5-and 10-h periods than after tablets. Granules gave significantly lower plasma levels than all other forms. Plasma levels were also measured during maintenance therapy, when a total of 200 g o,p′-DDD was administered to 22 patients with adrenocortical carcinoma. The plasma disappearance rate after termination of long-term therapy was found to be between 18 and 159 days. The recovery of o,p′-DDD from faeces was about five times higher after ingestion of tablets than after administration in oil emulsion and milk. As far as the rapid increase in plasma levels and patient compliance are concerned, the best results were obtained with the milk powder mixture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258213
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  • 3
    Electronic Resource
    Electronic Resource
    The distribution ofo,p′-DDD (Mitotane) among serum lipoproteins in normo- and hypertriglyceridemia (1992)
    Springer
    Cancer chemotherapy and pharmacology 29 (1992), S. 331-334 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We found that the distribution of the lipophilic chemotherapeutic agento,p′-DDD (mitotane) among serum (lipo)proteins was altered in hypertriglyceridemia, with relatively moreo,p′-DDD accumulating in the chylomicron and very-low-density lipoprotein (VLDL) fraction. Intralipid, an artificial chylomicron emulsion, or isolated VLDL could extracto,p′-DDD from the other serum (lipo)proteins. There was an inverse relationship between the relative amount ofo,p′-DDD found in the fraction exhibiting a density of 〈1.006 g/ml (chylomicrons plus VLDL) and the relative amount observed in the LDL or HDL fractions of serum. Our results indicate that hypertriglyceridemia may impede the entry ofo,p′-DDD into the brain or the adrenals. For therapeutic monitoring ofo,p′-DDD levels in severe hypertriglyceridemia, we recommend that the chylomicron and VLDL fraction first be removed from the serum by ultracentrifugation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685956
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  • 4
    Electronic Resource
    Electronic Resource
    O,p′-DDD (Mitotane) levels in plasma and tissues during chemotherapy and at autopsy (1982)
    Springer
    Cancer chemotherapy and pharmacology 9 (1982), S. 85-88 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of o,p′-DDD in various body compartments of patients being treated for metastatic adrenocortical carcinoma was studied. A highly significant semilogarithmic relationship was found between plasma and adipose tissue concentrations during therapy and between levels in plasma and adipose tissue and between plasma and brain at autopsy. A linear relationship was found at autopsy between concentrations in adipose tissue and those in various other tissues, such as tumour and brain. The semilogarithmic relationship can be explained by the assumption of two plasma pools for o,p′-DDD, one with low affinity and high capacity and one with high affinity and low capacity. Plasma concentrations must be carefully monitored to obtain an impression of the tumour concentration and to detect impending central nervous system intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265384
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  • 5
    Electronic Resource
    Electronic Resource
    Female pseudo-hermaphroditism due to an adrenal tumour in the mother (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 140-142 
    Details
    ISSN: 1432-1076
    Keywords: Female pseudo-hermaphroditism ; Adrenocortical adenoma ; Virilisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This is a report of a case of almost complete external virilisation of a girl due to an adrenocortical adenoma of the mother. The tumour, though present for many years, caused only mild symptoms in the mother; therefore detection followed only after birth of the virilised girl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445598
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of ORG 10172, a low molecular weight heparinoid, and digoxin in healthy volunteers (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 245-250 
    Details
    ISSN: 1432-1041
    Keywords: Org 10172 ; Digoxin ; heparinoid ; pharmacokinetics ; pharmacodynamics ; drug interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Potential pharmacokinetic and pharmacodynamic interactions between a new low molecular weight heparinoid Org 10172 (bolus injection of 3250 anti-Xa units) and digoxin (0.25 mg once daily for 8 days) were studied in 6 healthy male volunteers using an open, randomised three-way cross-over design. Digoxin produced a slight increase in clearance of anti-Xa activity from 4.3 to 4.8 ml·min−1, while plasma anti-thrombin and thrombin generation inhibiting (TGI) activity remained unchanged. Digoxin did not affect the actions of Org 10172 on the clotting tests. In the presence of Org 10172 there was a reduction in the AUC of digoxin during one dosing interval after the seventh digoxin tablet from 20 to 17 ng·ml−1·h, and a significant reduction in the average serum digoxin conentration. Since renal digoxin clearance was not significantly changed this probably might be due to a change in the non-renal clearance of digoxin. Atrio-ventricular node conduction, as measured by PR-time intervals, remained unchanged during all three treatments. In conclusion, although the pharmacokinetics of Org 10172 and digoxin were slightly changed by the combination, it is probably safe to administer Org 10172 and digoxin simultaneously. The clinical relevance of the slight decrease in plasma anti-Xa activity levels cannot yet be defined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315437
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  • 7
    Electronic Resource
    Electronic Resource
    Distribution of lipophilic xenobiotics among plasma lipoproteins (1991)
    Springer
    Archives of toxicology 65 (1991), S. 436-436 
    Details
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284270
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  • 8
    Electronic Resource
    Electronic Resource
    o, P'-DDD (mitotane) treatment for Cushing's syndrome: Adrenal drug concentration and inhibition in vitro of steroid synthesis (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 483-487 
    Details
    ISSN: 1432-1041
    Keywords: o,p'-DDD ; Cushing syndrome ; adrenal ; steroid synthesis ; mitotane ; tissue content ; dose-response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary o,p'-DDD is an inhibitor of adrenal steroid synthesis currently used for therapy of Cushing's syndrome. Conflicting data have been published on the relationship between the plasma level of the drug and its clinical and biological effects. The levels of o,p'-DDD and o,p'-DDE in various tissues obtained from treated patients have been measured and are compared with data on in vitro steroidogenesis in adrenal tissues from the same patients. o,p'-DDD was found in all samples and o,p'-DDE in half of them, both levels being high when the tissue lipid concentration was high. There was considerable variability in lipid content from one tissue to another and within a tissue from one sample to another; only the drug to lipid ratio seems able to provide a reproducible index of drug entry into a tissue. No relationship was found between the tissue concentration of the drug and the total dose administered or inhibition of the steroid biosynthetic step studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613466
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