ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The purpose of this study was to compare the bone regenerative effect of calciumphosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO.Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals weredivided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 gcalcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The ratswere sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological aswell as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400μm particles promoted new bone formation, while 40 μm particles inhibited it because of severeinflammation
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.165.pdf
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