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  • 1
    Electronic Resource
    Electronic Resource
    An observation about myelination (1983)
    Springer
    Experimental brain research 52 (1983), S. 219-225 
    Details
    ISSN: 1432-1106
    Keywords: Myelin ; Myelination ; Optic tract ; Model of myelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An analysis of the direction of myelination of fibers in the optic tract of a kitten shows that the direction of wrapping of neighboring fibers is not random. Adjacent fibers in contact with the same glial process tend to be wrapped in the same direction. A model for myelination is proposed to account for this observation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236630
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  • 2
    Electronic Resource
    Electronic Resource
    RESPIRATION IN IMMATURE RAT BRAIN MITOCHONDRIA (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 24 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Respiration was studied polarographically in mitochondria isolated from immature rat cerebral hemispheres. Respiratory rates are compared as a function of age, substrate, and the requirement for a phosphate acceptor.1. All respiratory rates are low in the first week of life. These rates increase during the first month and then decline to about the newborn rate by 5 weeks of age.2. With the NAD-linked substrate pair, glutamate and malate, the changes with age are significant only for the rate of ADP-dependent respiration. With succinate as substrate, significant age-dependent changes in respiration occur only in ADP-independent respiration.3. In mitochondria from animals less than five weeks of age, the ADP-dependent respiratory rate is significantly greater with the NAD-linked substrate pair than with succinate. In mitochondria from older animals, both ADP-dependent and ADP-independent rates are greater with succinate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb03670.x
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  • 3
    Electronic Resource
    Electronic Resource
    GRAMICIDIN INDUCED ION TRANSPORT IN BRAIN MITOCHONDRIA PREPARATIONS (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— —(1) Gramicidin at low concentrations induces an uptake of K+ and Na+ in brain mitochondria in a manner similar to that observed with liver mitochondria.(2) The cation uptake is energy dependent, and is accompanied by an ejection of H+ ions and a slight increase in respiration in the absence of added permeant anion.(3) The cation uptake and hydrogen ion release are both inhibited by agents which inhibit electron transport. Barbiturates and chlorpromazine inhibit the transport phenomenon by inhibiting electron transport.(4) In the presence of permeant anions (phosphate and acetate) respiration is stimulated quite significantly.(5) At high gramicidin concentrations there is a release of Na+ and K+ from the mitochondria and uptake of H+. There is also a cyclic reduction-oxidation of the nicotinamide adenine dinucleotides, which is believed to be due to the release from the mitochondria of the reduced dinucleotides followed by their subsequent oxidation.(6) The effect of high gramicidin on the mitochondrial nicotinamide-adenine dinucleotides and cation distribution is irreversible and is not blocked by individual inhibitors of respiration and of phosphorylation, but is prevented by prior addition of a mixture of these inhibitors.(7) Gramicidin is therefore believed to have a bimodal function; one on the mitochondrial membrane per se, and the other on the energy dependent ion accumulation apparatus.(8) A model of induced mitochondrial ion accumulation is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb11631.x
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  • 4
    Electronic Resource
    Electronic Resource
    STUDIES ON THE BIOCHEMICAL BASIS OF DISTAL AXONOPATHIES–I. INHIBITION OF GLYCOLYSIS BY NEUROTOXIC HEXACARBON COMPOUNDS (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Neurotoxic hexacarbon compounds 2,5-hexanedione (2,5-HD) and methyl n-butyl ketone (MnBK) inhibit crystalline and endogenous CNS and PNS glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Preincubation of the enzyme with the toxin was necessary for inhibition. The enzyme activity of GAPDH was preserved by the addition of dithiothreitol in the presence of either neurotoxin. By contrast, lactate dehydrogenase (LDH) activity was not inhibited by these neurotoxic chemicals. Neurologically inactive compounds 1,6-hexanediol and acetone failed to inhibit GAPDH. The present data indicate that 2,5-HD and M “BK block energy metabolism by inhibiting glycolysis at the site of GAPDH. These observations may account for the known failure of GAPDH-dependent axonal transport and the axonal degeneration which occurs in hexacarbon neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb04550.x
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  • 5
    Electronic Resource
    Electronic Resource
    The Uba2 and Ufd1 proteins of Saccharomyces cerevisiae interact with poly(A) polymerase and affect the polyadenylation activity of cell extracts (1997)
    Springer
    Molecular genetics and genomics 255 (1997), S. 209-218 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsSaccharomyces cerevisiae mRNA 3′-end processing ; Poly(A) polymerase ; Ubiquitin pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Poly(A) polymerase is responsible for the addition of the adenylate tail to the 3′ ends of mRNA. Using the two-hybrid system, we have identified two proteins which interact specifically with the Saccharomyces cerevisiae poly(A) polymerase, Pap1. Uba2 is a homolog of ubiquitin-activating (E1) enzymes and Ufd1 is a protein whose function is probably also linked to the ubiquitin-mediated protein degradation pathway. These two proteins interact with Pap1 and with each other, but not with eight other target proteins which were tested in the two-hybrid system. The last 115 amino acids of Uba2, which contains an 82-amino acid region not present in previously characterized E1 enzymes, is sufficient for the interaction with Pap1. Both Uba2 and Ufd1 can be co-immunoprecipitated from extracts with Pap1, confirming in vitro the interaction identified by two-hybrid analysis. Depletion of Uba2 from cells produces extracts which polyadenylate precursor RNA with increased efficiency compared to extracts from nondepleted cells, while depletion of Ufd1 yields extracts which are defective in processing. These two proteins are not components of polyadenylation factors, and instead may have a role in regulating poly(A) polymerase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050491
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  • 6
    Electronic Resource
    Electronic Resource
    Synergistic effect of AMP and fructose 2,6-bisphosphate on the protection of fructose 1,6-bisphosphatase against inactivation by trypsin (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 1305-1307 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The rate of inactivation of chicken liver fructose, 1,6-bisphosphatase by trypsin is reduced if the digestive reaction is conducted in the presence of AMP or fructose 2,6-bisphosphate. The effects of these 2 compounds are synergistic. Although fructose 1,6-bisphosphate does not protect the enzyme against tryptic inactivation, it can enhance the effect of AMP. Selective modification of the AMP allosteric site of fructose 1,6-bisphosphatase with pyridoxal-P and NaBH4 renders the enzyme more resistant to tryptic inactivation, but the modified enzyme is no longer responsive to the protective effect of AMP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990383
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  • 7
    Electronic Resource
    Electronic Resource
    Inez Cavert's article (1953)
    Springer
    Pastoral psychology 4 (1953), S. 6-6 
    Details
    ISSN: 1573-6679
    Source: Springer Online Journal Archives 1860-2000
    Topics: Theology and Religious Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01838939
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