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  • 1
    Electronic Resource
    Electronic Resource
    Interactions between Hematopoietic Growth Factors in Normal and Leukemic Stem Cell Differentiation (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 567 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb16469.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy (1989)
    Springer
    Biotherapy 1 (1989), S. 293-300 
    Details
    ISSN: 1573-8280
    Keywords: interleukin-1 ; marrow progenitors ; radiation ; chemotherapy ; hematopoietic growth factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently it has been recognized that IL-1 plays an important role in hematopoietic regulation. Administration of 5-fluorouracil (5-FU) to mice causes prolonged neutropenia. rHIL-1 injected to mice after 5-FU, accelerated the recovery of hematopoietic progenitors and blood neutrophils. The combination of rhIL-1 and rhG-CSF reduced the neutropenic period significantly. Sublethal irradiation of mice induced profound neutropenia for 3 weeks which was associated with 80% mortality. Administration of rhIL-1 20 hours prior to or 2 hours post irradiation resulted in a significantly improved survival and rapid recovery of the neutrophil count. IL-1 administered alone or in combination with other colony stimulating factors to spontaneous breast tumor bearing mice following 5-FU therapy resulted in a rapid recovery of neutrophils, improved survival, and markedly reduced the tumor mass. Experiments in primates demonstrated that rhIL-1 administered to 5-FU treated animals shortened the neutropenic period from 30 to 17 days and increased the number of marrow progenitors responsive to other CSFs. Prolonged administration of IL-1 (14 days) to these animals resulted in a delayed neutrophil recovery as compared to animals receiving short courses of IL-1. rhIL-1 administered to primates receiving marrow grafts after lethal irradiation, did not result in rapid hematopoietic recovery. In humans, studies with CD-34 positive marrow cells showed that IL-1 had a radioprotective effect on a committed and early marrow progenitors. These data show the therapeutic potential of IL-1 in the treatment of chemoradiotherapy induced myelosuppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171005
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  • 3
    Electronic Resource
    Electronic Resource
    Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice (2003)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 1200-1207 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Existing protocols for the neural differentiation of mouse embryonic stem (ES) cells require extended in vitro culture, yield variable differentiation results or are limited to the generation of selected neural subtypes. Here we provide a set of coculture conditions that allows rapid and efficient ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt870
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  • 4
    Electronic Resource
    Electronic Resource
    T-cell growth factor (Interleukin 2) and terminal transferase activity in human leukemias and lymphoblastic cell lines (1981)
    Springer
    Annals of hematology 43 (1981), S. 99-103 
    Details
    ISSN: 1432-0584
    Keywords: Interleukin 2 ; Terminal transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mononuclear blood cells from patients with different types of leukemia, and from controls as well as cells from established lymphoblastic cell lines were analyzed with respect to terminal transferase (TdT) activity and T-cell growth factor (TCGF; Interleukin 2, IL-2), to determine the significance of TCGF production and response as functional markers for human leukemias. The data obtained so far suggest that the aberrant proliferation and lack of maturation observed in these leukemias may be associated with or be the result of a break-down in cellular-mediated control of proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320468
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  • 5
    Electronic Resource
    Electronic Resource
    Defective T-cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and itsin vitro correction by interleukin 2 (1983)
    Springer
    Journal of clinical immunology 3 (1983), S. 332-340 
    Details
    ISSN: 1573-2592
    Keywords: Interleukin 2 ; homosexuals ; mitogenic T-cell monoclonal antibodies ; acquired immunodeficiency syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies OKT3 and Pan T2, to induce proliferation and interleukin 2 (IL2) production in peripheral blood lymphocytes (PBL) from 21 homosexual patients: 12 with Kaposi's sarcoma (KS), 4 with reactive lymphadenopathy, and 5 with opportunistic infections. All patients with KS and opportunistic infections had significantly lower mitogen-stimulated DNA synthesis, as compared to the controls, irrespective of the mitogen used (P〈0.01). The patients with lymphadenopathy exhibited significantly lower responses only in the OKT3 assay as compared to normals (P=0.009). The production of endogenous IL2 was significantly lower in PBL cultures from patients with KS and with opportunistic infections, irrespective of the mitogen used, as compared to healthy male controls, and also significantly lower in the Pan T2-stimulated cultures from patients with lymphadenopathy. The addition of highly purified IL2 was able to restore partially lymphocyte proliferationin vitro in the presence of these mitogens in all patients. Our studies demonstrate (1) that male homosexuals even without clinical manifestations of immunodeficiency frequently exhibit a proliferative T-cell defect when anti-T-cell monoclonal antibodies rather than PHA are used as mitogens, (2) that this proliferative defect is associated with defective IL2 production, and (3) that this defect is at least in part correctablein vitro by highly purified IL2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915794
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  • 6
    Electronic Resource
    Electronic Resource
    Colony-stimulating factors (1989)
    Springer
    Breast cancer research and treatment 14 (1989), S. 193-200 
    Details
    ISSN: 1573-7217
    Keywords: bone marrow transplantation ; chemotherapy ; granulocyte colony-stimulating factor (GCSF) ; granulocyte-macrophage colony-stimulating factor (GMCSF) ; immunosuppression ; interleukin-1 ; interleukin-3 ; myelosuppression ; neutropenia ; platelets ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One of the most exciting recent developments in cancer-related research has been the discovery and understanding of colony-stimulating factors. There is now a general optimism that these factors will be used in the treatment of a variety of solid tumors, lymphomas, and leukemias, as well as in the treatment of patients who are immunocompromised or undergoing bone marrow transplantation. We have gathered a distinguished panel of experts to discuss the current status of this rapidly moving field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01810735
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  • 7
    Electronic Resource
    Electronic Resource
    Hematopoietic growth factor receptors (1989)
    Springer
    Cytotechnology 2 (1989), S. 269-286 
    Details
    ISSN: 1573-0778
    Keywords: hematopoiesis ; growth factor ; receptors ; modulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive investigations of their biochemical properties and biological effects and functions. The HGF's act on target cells by binding to receptors. The kinetics and, to an even larger extent, dynamics of the factor/receptor associations display several intriguing characteristics, most of which are still poorly understood. Herein, the biochemical characteristics of HGF's receptors as well as the binding properties, post-receptor binding events and receptor modulation resulting from the association of HGF's and their target cells are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364993
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  • 8
    Electronic Resource
    Electronic Resource
    Induction and long-term maintenance of Thy-1 positive T lymphocytes: Derivation from continuous bone marrow cultures (1980)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 13 (1980), S. 533-539 
    Details
    ISSN: 0091-7419
    Keywords: T lymphocytes ; TCGF ; continuous marrow cultures ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: In the present study we investigated the presence of T-lymphocyte progenitors in the long-term murine bone marrow culture system described by Dexter: mature Thy-1 antigen-bearing T lymphocytes are lost in these cultures after a few days. By culturing nonadherent cells from such cultures in the presence of a supernatant of concanavalin A-stimulated spleen cells, a source of T-cell growth factor, we found that Thy-1 positive blast cells proliferated together with a second population of Thy-1 negative cells. These two populations of cells have been maintained in long-term in vitro cultures by passaging the cells in fresh conditioned medium at regular intervals. Moreover, we have been able to establish pure cultures of the Thy-1-bearing blast cells after separating them from the non-T cells using their adherence property to plastic surfaces. Long-term cultures of T lymphocytes can thus be established from long-term marrow cultures as well as from the spleen, thymus or fresh bone marrow.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400130412
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  • 9
    Electronic Resource
    Electronic Resource
    G-CSF: Its relationship to leukemia differentiation-inducing activity and other hemopoietic regulators (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 113 (1982), S. 53-64 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The murine myelomonocytic leukemia WEHI-3B exists as differentiation-inducible (D+) and noninducible (D-) cell lines. Both lines produce a CSF species that stimulates exclusively the formation of neutrophil granulocyte colonies. This G-CSF copurifies with a mast cell growth factor but can be separated from M- and GM-CSF. NZB bone marrow is unresponsive to G-CSF stimulation. WEHI-3B D+ cells can be induced to terminal granulocyte differentiation by a factor present in murine and human postendotoxin serum that is different from G-CSF present in WEHI-3B D+ or D- CM since the latter has little or no leukemia differentiation-inducing activity. Endotoxin treatment of C. parvum primed mice leads to simultaneous induction of serum activities with selective action on myeloid leukemic cells, a serum differentiation inducing activity and a leukemic colony inhibitory activity. These factors act synergistically to block leukemic stem cell self-renewal. The results suggest that a variety of inducible factors may have potent and selective antileukemic activity.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041130411
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