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  • 1
    Electronic Resource
    Electronic Resource
    The Relationship between Coronary Artery Diseases and Magnesium Deficiency, with Regard to Coronary Artery Spasms (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 676 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb38747.x
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  • 2
    Electronic Resource
    Electronic Resource
    Increases in tumor necrosis factor-α following transient global cerebral ischemia do not contribute to neuron death in mouse hippocampus (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 93 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The actions of tumor necrosis factor-α (TNF-α) produced by resident brain cells and bone marrow-derived cells in brain following a transient global ischemia were evaluated. In wild-type mice (C57Bl/6J) following 20 min ischemia with bilateral common carotid artery occlusion (BCCAo), TNF-α mRNA expression levels in the hippocampus were significantly increased at 3 h and 36 h and exhibited a biphasic expression pattern. There were no hippocampal TNF-α mRNA expression levels at early time points in either wild-type mice bone marrow transplanted (BMT)-chimeric-TNF-α gene-deficient (T/W) or TNF-α gene-deficient mice BMT-TNF-α gene-deficient mice (T/T), although TNF-α mRNA levels were detectable in T/W BMT mice at 36 h. Histopathological findings showed no intergroup differences between wild-type and TNF-α gene-deficient mice at 4 and 7 days after transient ischemia. In addition, nuclear factor-κB (NF-κB) was activated within 12 h after global cerebral ischemia, but electrophoretic mobility shift assays (EMSA) showed no intergroup differences between wild type and TNF-α gene-deficient mice. In summary, early hippocampal TNF-α mRNA expression may not be related to bone marrow-derived cells, and secondary TNF-α expression as early as 36 h after ischemia probably resulted mainly from endogenous brain cells and possibly a few bone marrow-derived cells. Although we cannot exclude the possibility of the TNF-α contribution to the physiologic changes of hippocampus after transient global ischemia, these results indicate that TNF-α does not influence the morphological changes of the hippocampal neurons under our study condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03163.x
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  • 3
    Electronic Resource
    Electronic Resource
    A technique for measurement of jet penetration in hot fluidized beds with a modified Pitot-tube probe (1988)
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 27 (1988), S. 1011-1016 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie00078a021
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  • 4
    Electronic Resource
    Electronic Resource
    SAFETY EXAMINATION OF SOME EDIBLE OR MEDICINAL PLANTS AND PLANT CONSTITUENTS, PART 3 (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food safety 2 (1980), S. 0 
    Details
    ISSN: 1745-4565
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The carcinogenicity of vicia, galanga, lathyrus and lycium, which are plants used as human food or in folk medicine, and of caffeic acid and prunasin, which are plant constituents, was examined in an inbred strain of ACI rats. Fresh plant materials were dried, milled and mixed with the rat basal diet in the ratio of 16% and 33% of the total. The plant constituents, caffeic acid and prunasin, were mixed with the basal diet in the ratio of 0.5% and 0.03%, respectively. These diets were administered to rats for periods ranging upward from 180 days. Carcinogenic activity was not observed with any of the plants or plant constituents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4565.1980.tb00397.x
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  • 5
    Electronic Resource
    Electronic Resource
    A pneumatic probe to detect gas bubbles in fluidized beds. 2. Response of the probe (1984)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 23 (1984), S. 116-119 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i100013a022
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  • 6
    Electronic Resource
    Electronic Resource
    Silver-stained nucleolar organizer regions in the normal, hyperplastic and neoplastic endometrium (1991)
    Springer
    Virchows Archiv 419 (1991), S. 493-497 
    Details
    ISSN: 1432-2307
    Keywords: Menstrual cycle ; Hyperplasia ; Carcinoma ; Nucleolar organizer regions ; Endometrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The numbers of silver-stained nucleolar proteins (AgNORs) were counted in hyperplastic and neoplastic lesions of the endometrium and compared with those of normal proliferative and secretory phase endometrium. In glandular cells in the normal menstrual cycle, the mean number of AgNORs in proliferative phase endometrium (3.8) was significantly higher than that in secretory phase endometrium (2.7,P〈0.05). The mean number of AgNORs in well-differentiated endometrioid type adenocarcinoma (5.5) was significantly higher than that in both complex hyperplasia without cytological atypia (3.6,P〈0.01), and simple hyperplasia (3.3,P〈 0.01). Mean AgNOR counts in complex hyperplasia with cytological atypia were greater than those in both complex hyperplasia without cytological atypia (P〈0.05) and simple hyperplasia (P〈0.05). Thus, complex hyperplasia with cytological atypia appears to be a direct precursor of well-differentiated endometrioid type adenocarcinoma. These findings suggest that the mean numbers of AgNORs are increased in neoplastic changes in the endometrium, and the one-step colloid method for AgNORs may therefore be a simple and useful technique to examine proliferative activity in neoplastic and pre-neoplastic endometrial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01650678
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  • 7
    Electronic Resource
    Electronic Resource
    WAF1 expression andp53 mutations in human colorectal cancers (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 118-123 
    Details
    ISSN: 1432-1335
    Keywords: p53 mutation ; WAF1 ; Colorectal cancer ; Western blot ; PCR-SSCP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of theWAF1 gene was examined in the tissues of primary colorectal cancers and of adjacent non-neoplastic mucosas by Western blot analysis.p53 mutations of these cancer tissues were also analyzed by the polymerase chain reaction/single-strand conformation polymorphism followed by direct sequencing. Missense mutations ofp53 were recognized in 19 out of 40 cases. Five cancers (12.5%) displayed much lower expression of WAF1 than did their corresponding mucosas, and all of them contained mutantp53. Fourteen cancers (35%) expressed the same level of WAF1 as their mucosas, and 5 of them had mutantp53. Twenty-one cancers (52.5%) had much higher WAF1 expression than their mucosas, and 9 of them had mutantp53. When Duke's classification was applied to these colorectal cancers, it was found that the cancers with reduced expression of WAF1 basically coincided with late (C or D) stages (4 out of 5 cases). while the cancers with higher WAF1 expression were consistent with early (A or B) stages (17 out of 21 cases). Down-regulation of WAF1 in colorectal cancer tissues may be implicated in tumor progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01269890
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  • 8
    Electronic Resource
    Electronic Resource
    Overexpression of cyclin B1 in human colorectal cancers (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 124-127 
    Details
    ISSN: 1432-1335
    Keywords: Cyclin B1 ; Western blot ; Southern blot ; PCNA ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of the human cyclin B1 gene was investigated with Western blot analysis in human colorectal carcinomas and in adjacent non-neoplastic colorectal mucosas. Out of 41 cancers, 36 (88% of patients) showed much higher expression of cyclin B1 than did the non-neoplastic mucosa. Proliferating-cell nuclear antigen (PCNA) immunohistochemistry revealed that the labeling indexes of these cancer tissues were 47.3±11.3% while those of the mucosa were 15.6±5.5%. Only 5 cancers (12% patients) demonstrated the same expression level of cyclin B1 as the mucosa; however, the PCNA labeling indexes were 42.3±11% for the cancer tissue, compared to 12.6±2.4% for the mucosas. Southern blot analysis showed that there was no change of the cyclin B1 gene at the somatic DNA level in spite of its high expression at the protein level. These results proved that majority of colorectal cancers express high levels of cyclin B1, consistent with a high rate of cell proliferation, whereas a small fraction of these cancers lose control of cyclin B1 expression, diverging from their fast cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01269891
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  • 9
    Electronic Resource
    Electronic Resource
    Changes of silver-stained nucleolar organizer regions in mouse endometrial carcinogenesis induced byN-methyl-N-nitrosourea and 17β-oestradiol (1992)
    Springer
    Virchows Archiv 421 (1992), S. 387-391 
    Details
    ISSN: 1432-2307
    Keywords: Hyperplasia ; Carcinoma ; Nucleolar organizer regions ; Endometrium ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A high incidence of endometrial adenocarcinoma and pre-neoplastic lesions was induced in ICR mice treated withN-methyl-N-nitrosourea and 17β-oestradiol within 23 weeks. The endometrial lesions were histopathologically similar to those of human subjects. To assess the cell proliferative activity of these lesions, a one-step silver colloid staining for nucleolar organizer regions was applied and the numbers of silver-stained nucleolar organizer regions (AgNORs) were counted. The mean numbers±SD of AgNORs in each lesion were as follows: simple hyperplasia, 2.07±0.36; complex hyperplasia without cytological atypia, 2.79±0.39; complex hyperplasia with cytological atypia, 3.43±0.38; and well-differentiated adenocarcinoma, 4.17±0.40. Significant differences were observed in each lesion (P〈0.001). These findings suggest that the mean numbers of AgNORs are increased in the progression of neoplastic changes in the mouse endometrium, as in human endometrial lesions. This rapid induction model of endometrial carcinoma in mice is useful in the understanding of the histogenesis of endometrial carcinoma in human subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606910
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  • 10
    Electronic Resource
    Electronic Resource
    Rapid detection of proliferating potential in human brain tumors by nucleolar organizer region staining on squash preparations (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 510-514 
    Details
    ISSN: 1432-1335
    Keywords: Brain tumors ; Nucleolar organizer regions ; Proliferating potential ; Rapid detection ; Squash preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rapid detection of the proliferating potential of 37 human brain tumors was attempted using squash preparations stained by a silver colloid technique for argyrophilic protein associated with nucleolar organizer regions (AgNORs). Less than 1 h was required for staining. The mean number of AgNORs in cell nuclei of malignant or recurrent brain tumors (16 cases) including meningeal sarcoma, recurrent meningioma, recurrent craniopharyngioma, anaplastic astrocytoma, glioblastoma multiforme and metastatic brain tumor was 3.18, and the number for benign brain tumors (21 cases) including meningioma, neurinoma, pituitary adenoma, benign astrocytoma, ependymoma, and adenoma of lachrymal gland was 1.85. The former value was significantly greater than the latter value (P〈0.001). These results indicate that quantitative analysis of AgNORs in brain neoplastic cells, using squash preparations, is useful to differentiate malignant from benign tumors within 1 h. Thus, this method provides rapid and useful information about the proliferative potential of human brain tumors even during operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01613280
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