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  • 1
    Electronic Resource
    Electronic Resource
    Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups (1996)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 16 (1996), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A fall in nocturnal plasma melatonin occurs in patients with cluster headache, suggesting that melatonin may play a role in the promotion of attacks. During a cluster period, we administered melatonin to 20 cluster headache patients (2 primary chronic, 18 episodic) in a double-blind placebo-controlled study of oral melatonin 10 mg (n=10) or placebo (n=10) for 14 days taken in a single evening dose. Headache frequency was significantly reduced (ANOVA, p〈0.03) and there were strong trends towards reduced analgesic consumption (ANOVA, p〈0.06) in the treatment group. Five of the 10 treated patients were responders whose attack frequency declined 3–5 days after treatment, and they experienced no further attacks until melatonin was discontinued. The chronic cluster patients did not respond. No patient in the placebo group responded. There were no side effects in either group. Although the response rate is low, melatonin may be suitable for cluster headache prophylaxis in some patients, particularly those who cannot tolerate other drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1996.1607494.x
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  • 2
    Electronic Resource
    Electronic Resource
    Internal ophthalmoplegia associated with migraine attacks (1994)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 14 (1994), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The case of a young woman presenting with repeated headache episodes associated with right eye midriasis is described. CT scan, MR of the brain and selective cerebral angiography were unremarkable. Tyramine eyedrop response suggested parasympathetic hypofunction on the affected side. The diagnosis of ophthalmoplegic migraine is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1994.1406461.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache (1995)
    USA/Oxford, UK : American Association for the Study of Headache/Blackwell Science Ltd
    Cephalalgia 15 (1995), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The cyclic recurrence of cluster periods and the regular timing of headache occurrence in cluster headache (CH) induced us to study the circadian secretion of melatonin and cortisol in 12 patients with episodic CH, during a cluster period, and compare them with 7 age- and sex-matched healthy controls. Blood was sampled every 2, h for 24 h. All subjects were confined to a dark room from 22.00 to 08.00. Plasma melatonin levels were significantly reduced in CH patients (repeated measures ANOVA p 〈 0.03; mesor p 〈 0.02), and the cortisol mesor was significantly increased (p 〈 0.03). Amplitudes and acrophases did not differ between the groups. Individual cosinor analysis showed that 412 (33.3%) CH patients had no significant melatonin rhythm, and that 5/11 (45.5%) had no cortisol rhythm. Group analysis of cosinor revealed significant rhythmicity of melatonin and cortisol secretion in both groups. In controls, the timing of melatonin and cortisol acrophase significantly correlated with each other, indicating that the biorhythm controllers for the secretion of these hormones were synchronized. Such correlation was not found in the CH patients; mesor, amplitude and acrophase of melatonin and cortisol did not correlate with duration of illness, duration of headache in course, or time since last headache attack.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1995.015003224.x
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  • 4
    Electronic Resource
    Electronic Resource
    General considerations on the symptomatic and prophylactic treatment of cluster headache (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. S60 
    Details
    ISSN: 1126-5442
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00015003
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacological and behavioral treatment of pediatric migraine and tension-type headache (1998)
    Springer
    Neurological sciences 19 (1998), S. 59-64 
    Details
    ISSN: 1590-3478
    Keywords: Pediatric headache ; Pharmacological treatment ; Behavioral approach ; Biofeedback
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The problem concerning the treatment of pediatric headache has been the object of several recent reports. Some of the same medications used to treat adult headache problems are also utilized with children but usually at smaller dosages and in different combinations. The recent application of behavioral approaches, in particular biofeedback, for treatment of children’s headaches has been an effective alternative to drugs without the problematic and dangerous side effects of pharmacological treatments. The purpose of this review is to give some indications about the most common pharmacological therapies for migraine and tension-type headache in children, and also to discuss the use of behavioral therapies, in particular biofeedback, as excellent alternatives to drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427557
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  • 6
    Electronic Resource
    Electronic Resource
    A review of the treatment of primary headaches. Part I: Migraine (1995)
    Springer
    Neurological sciences 16 (1995), S. 577-586 
    Details
    ISSN: 1590-3478
    Keywords: Migraine ; Acute treatment ; Prophylaxis ; Biofeedback ; Status migrainosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario L'emicrania è un disturbo che colpisce circa il 15% della popolazione generale risultando spesso debilitante tale da risultare un problema clinico di rilievo soprattutto quando refrattario alla terapia. Questo articolo fornisce una guida razionale ed aggiornata al trattamento di questa malattia, sia per gli attacchi che per la profilassi. Per quanto riguarda gli attacchi i farmaci risultati efficaci nei diversi studi clinici controllati sono l'aspirina, gli analgesici, gli antiinfiammatori non steroidei, gli ergot derivati ed il sumatriptan. I farmaci riconosciuti efficaci nella profilassi dell'emicrania sono identificabili tra 5 principali categorie di sostanze: beta-bloccanti, calcio antagonisti, serotonino-modulatori, antiinfiammatori non steroidei e gli ergot derivati. Tra le terapie non farmacologiche, viene brevemente discussa l'utilità del biofeedback nella prevenzione di alcune forme di emicrania. Vengono inoltre discusse le numerose variabili che influenzano la scelta del farmaco sia per la profilassi che per l'attacco con le relative controindicazioni.
    Notes: Abstract Finding the best treatment for a patient's migraine is often a problem in clinical practice since the condition is very common, often debilitating and may prove refractory to therapy. Over recent years, more effective migraine treatments have been found and validated, and the traditional remedies have undergone controlled testing. This article reviews the various therapies available for both the acute treatment and prevention of migraine. Treatments often effective against migraine attacks are: aspirin, analgesics, non steroid antiinflammatory drugs (NSAIDs), ergot derivatives and sumatriptan. Five main classes of prophylactic drug are currently used: beta-blockers, calcium antagonists, serotonin modulators, NSAIDs and ergot compounds. Biofeedback, one of the most efficacious non-pharmacological preventive treatments of migraine, is also discussed. The variables influencing the choice of acute and preventive treatments, including contriandications and drug availability, are also described in order to provide a practical and up-to-date guide to migraine therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230907
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    Paper (German National Licenses)
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