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  • 1
    Digitale Medien
    Digitale Medien
    Identification and Distribution of Neuroleptic Binding Sites in the Rat Spinal Cord (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Identification of neuroleptic receptor sites in the rat spinal cord could be achieved by the binding of [3H]haloperidol to membranes taken from the different horns. The use of pooled frozen microdiscs punched from these different spinal cord areas allowed the detection of saturable stereospecific binding, as defined in the presence of (+)- and (-)-butaclamol. Comparison of the binding constants with those obtained in the corpus striatum resulted in similar dissociation constants and Hill's slopes. Maximal binding capacity was quite different, being the greatest in the whole striatum (157 ± 8 fmol/mg protein) followed by the dorsal horn (56 ± 3 fmol/mg protein) and the lateral (34 ± 5 fmol/mg protein) and ventral ones (31 ± 2 fmol/mg protein). The displacement of the labelled ligand by different dopaminergic and nondopaminergic drugs at various concentrations gave similar results in the whole striatum and the spinal cord, giving further support for the existence of a dopaminergic innervation of the spinal cord and showing that dopaminergic receptor sites are distributed through the different spinal horns, with a maximal density in the dorsal horn–as for dopamine levels. No detectable stereospecific binding could be obtained from the surrounding spinal white matter, even at high tissue concentrations. Owing to poor sensitivity of the binding technique, no stereospecific neuroleptic binding could be demonstrated in the whole spinal cord, even at very high tissue concentration, whereas it could be detected in spinal cord tissue sampled from restricted areas of dense dopaminergic innervation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb05290.x
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  • 2
    Digitale Medien
    Digitale Medien
    Synthesis of diphosphine dioxides for extraction of actinides using supported liquid membranes technology (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Heteroatom Chemistry 6 (1995), S. 533-544 
    Details
    ISSN: 1042-7163
    Schlagwort(e): Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A recurrent method for synthesis of diphosphine dioxides to be used for extraction of actinides from acidic aqueous solution is described. Selective phosphonium salt formation and cleavage permits the stepwise introduction of different bridges between the phosphorus atoms as well as various chains on them. The influence of the structural parameters on liquid-liquid extraction properties of plutonium, neptunium, and americium is studied. Plutonium and neptunium can be efficiently removed from radioactive contaminated liquid wastes, using the supported liquid membranes technology with the more lipophilic organophosphorus extractants. © John Wiley & Sons, Inc.
    Zusätzliches Material: 9 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hc.520060608
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  • 3
    Digitale Medien
    Digitale Medien
    Facile and General Synthesis of Polyphosphane Polyoxides with (O)PCP(O) Linkages (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 1561-1569 
    Details
    ISSN: 1434-193X
    Schlagwort(e): Arbuzov reaction ; Phosphane oxide carbanion ; PCP linkage ; NMR spectroscopy ; Carbanions ; Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Polyphosphane polyoxides with (O)PCP(O) linkages are powerful chelating agents for extraction of actinides from nuclear wastes. They are obtained either by the Michaelis-Arbuzov reaction of chloromethylphosphane oxides and phosphorus(III) esters, or by the reaction of phosphane oxide carbanions with chlorophosphanes. With the latter method, the addition of a phosphane oxide carbanion in excess allowed us to overcome a transmetallation reaction and thereby obtain polyphosphane polyoxides in good yields. The 1H-NMR spectra of the PCH2P groups show the influence of the different R groups attached to the phosphorus atoms. We determined the coupling constants and the chemical shifts of these spin systems.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
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