ISSN:
1438-2199
Keywords:
NMDA antagonists
;
Motor response complications
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In animal models of Parkinson's disease (PD), glutamate antagonists diminish levodopa (LD)-associated motor fluctuations and dyskinesias. We sought to investigate if these preclinical observations can be extended to the human disease, by evaluating the effects of three non-competitive NMDA antagonists (dextrorphan, dextromethorphan and amantadine) on the motor response to LD in patients with advanced PD. In four separate trials, adjuvant therapy with these drugs reduced LD-induced dyskinesias and motor fluctuations. These findings support the view that drugs acting to inhibit glutamatergic transmission at the NMDA receptor can ameliorate LD associated motor response complications.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01345246
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