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  • 1
    Electronic Resource
    Electronic Resource
    Extractable immune complex in soluble substances from psoriatic scales (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 45-51 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis vulgaris ; Soluble substances of psoriatic scales ; Immune complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Soluble substances of psoriatic scales (Psoexts) were analysed immunologically to detect immune complex (IC) related to the immune reactions in psoriatic lesions and compared with extracts of scales from a patient with erythroderma due to pityriasis rubra pilaris (PRP-exts) as control. Immunoelectrophoretically IgG, IgA and C3 were detected in Pso-exts, but in PRP-exts only IgG was seen as immunological reactive substances. When analysed by Sephadex G-200 column chromatography, IgG and IgA eluates were found in Pso-exts with a molecular weight of more than 200,000 daltons. By Raji cell assay, the IgG and IgA eluates were shown to have IC characteristics and they were the IC composed of IgG-IgA, which was also confirmed using anti-IgG affinity chromatography. The IC seemed to be binding the epidermal proteins as antigen. Thesefindings suggest that deposits of immunoglobulins and complement in the stratum corneum of psoriatic lesions are not just secondary to the underlying inflammation in the dermis but that the IC detected is related to the immune reactions in psoriatic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412562
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Natural killer cell numbers and function in peripheral lymphoid cells in Behcet's disease (1985)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 113 (1985), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have studied NK cell activity and numbers in the peripheral blood obtained from patients with Behcet's disease and from normal healthy controls. NK cell activity in the peripheral blood of patients in the clinically-active stage of Behcet's disease was significantly lower than that of patients in the inactive stage and normal controls. In contrast, it was observed that the actual number of NK cells was markedly increased in the peripheral blood of patients with active disease. The addition of α-interferon (INF-α) to these cells showed significant augmentation of NK cell activity. These results suggest that the patients with active Behcet's disease lack a factor which activates NK cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1985.tb02083.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The molecular cloning and sequencing of the nitrilase gene of Rhodococcus rhodochrous PA-34 (1995)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 15 (1995), S. 297-306 
    Details
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The nitrilase of Rhodococcus rhodochrous PA-34 catalyzes the production of optically active amino acids from aminonitriles. The amino acid sequence of the NH2 terminus of the purified nitrilase was determined for the preparation of a synthetic oligonucleotide as a southern hybridization probe. A 9.5-kbp Pst I-fragement, which hybridized with the oligonucleotide probe, was isolated from R. rhodochrous PA-34 genomic libraries constructed in pUC 19. Nucleotide sequence analysis revealed that the nitrilase gene codes for a putative polypeptide of 380 amino acids which correspond to a relative molecular weight of 41, 723.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/abio.370150308
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    Paper (German National Licenses)
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