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  • 1
    Electronic Resource
    Electronic Resource
    Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration (1988)
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 67-69 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In darkness a steady Ca2+ influx into the photoreceptor outer segment through the light-dependent channels12-14 is balanced by an equal efflux of Ca2+ by Na+-Ca2+ exchange15"17. Light closes the channels, and the continued extrusion of Ca2+ produces a decrease in Ca2+ (refs 8,18-20). In an attempt ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/334067a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The acetate regulatory gene facB of Aspergillus nidulans encodes a Zn(II)2Cys6 transcriptional activator (1997)
    Springer
    Molecular genetics and genomics 254 (1997), S. 495-504 
    Details
    ISSN: 1617-4623
    Keywords: Key words Acetate metabolism  ;  facB  ;  Zn(II)2Cys6 (C6 zinc) binuclear cluster  ;  Aspergillus  ;  Gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Genetic studies have indicated that the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation. Sequencing of the facB gene revealed that it encodes a protein that contains an N-terminal GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster for DNA binding, leucine zipper-like heptad repeat motifs and central and C-terminal acidic α-helical regions, consistent with a function as a DNA-binding transcriptional activator. The Zn(II)2Cys6 cluster shows strong similarity with those of the Saccharomyces cerevisiae carbon metabolism regulatory proteins CAT8 and SIP4. A significant level of similarity with CAT8 is found throughout the length of the protein, suggesting at least partial functional homology. The facB genes of Aspergillus oryzae and Aspergillus niger were also sequenced and found to be highly conserved. Deletion of the facB gene confirmed that it is required for growth on acetate as a sole carbon source. Functional dissection using deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of the protein are required for function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050444
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  • 3
    Electronic Resource
    Electronic Resource
    Clindamycin and primaquine as primary treatment for mild and moderately severePneumocystis carinii pneumonia in patients with AIDS (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 204-207 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The combination of clindamycin and primaquine was investigated as primary treatment for mild or moderately severePneumocystis carinii pneumonia (alveolar-arterial oxygen gradient 〈40 torr) in 36 AIDS patients. All patients were treated with primaquine 30 mg (base) orally for 21 days. The first 22 patients were treated with clindamycin 900 mg i.v. q8h for the first 10 days, followed by clindamycin 450 mg q6h orally for 11 days. Twenty of these 22 patients (91 %) showed a marked clinical response by day 7. Four patients were later withdrawn from the study due to toxicity. An additional 14 patients were treated with an entirely oral regimen of clindamycin and primaquine. Thirteen of the 14 patients (93 %) showed a marked therapeutic response and 12 (86 %) successfully completed treatment. The combination of clindamycin and primaquine appears to be an effective and well-tolerated treatment for mild to moderately severePneumocystis carinii pneumonia in AIDS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964465
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