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  • 1
    Electronic Resource
    Electronic Resource
    The Large-Scale Isolation of Bryostatin 1 from Bugula neritina Following Current Good Manufacturing Practices (1991)
    s.l. : American Chemical Society
    Journal of natural products 54 (1991), S. 1265-1270 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50077a004
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  • 2
    Electronic Resource
    Electronic Resource
    High-temperature nematic liquid crystal for gas liquid chromatography (1980)
    s.l. : American Chemical Society
    Analytical chemistry 52 (1980), S. 2417-2420 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50064a042
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  • 3
    Electronic Resource
    Electronic Resource
    Neat and admixed mesomorphic polysiloxane stationary phases for open-tubular column gas chromatography (1988)
    s.l. : American Chemical Society
    Analytical chemistry 60 (1988), S. 1119-1124 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00162a007
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution of the liver carcinogen methapyrilene in fischer rats and its interaction with macromolecules (1982)
    Springer
    Journal of cancer research and clinical oncology 103 (1982), S. 69-73 
    Details
    ISSN: 1432-1335
    Keywords: Methapyrilene ; Liver tumor ; Rat ; Interaction ; Radioactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The anti-histaminic drug methapyrilene hydrochloride, which induces liver tumors in rats, was labeled with tritium by exchange and administered at a dose of 21 mg containing 700 μCi to each of 15 male Fischer rats. At 1 h, 6 h, 14 h, 24 h, and 44 h after treatment three rats were killed and their livers, pancreas, kidneys, and lungs were removed. The pooled organs were homogenized and DNA, RNA, and soluble protein were isolated from each. The extent of interaction of radioactive methapyrilene with liver nucleic acids was exceedingly small and did not differ significantly from the binding to nucleic acids in kidney, lung, or pancreas, which are not target organs of this carcinogen in rats. Binding of radioactivity to soluble proteins of the liver was considerable and substantially greater than in the other organs. If the mechanism of carcinogenic action of methapyrilene involves covalent interaction with DNA this must be at a very low and highly specific level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410307
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  • 5
    Electronic Resource
    Electronic Resource
    Production of brefeldin-A (1995)
    Springer
    Journal of industrial microbiology and biotechnology 15 (1995), S. 5-9 
    Details
    ISSN: 1476-5535
    Keywords: brefeldin-A ; Eupenicillium brefeldianum ; antitumor antibiotic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture byEupenicillium brefeldianum, (B. Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570006
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  • 6
    Electronic Resource
    Electronic Resource
    Chromatographic separation of benzo(a)pyrene isomers on nematic liquid crystal GC and polymeric reversed-phase HPLC phases (1981)
    Springer
    Chromatographia 14 (1981), S. 655-660 
    Details
    ISSN: 1612-1112
    Keywords: GC ; HPLC ; Liquid crystal GC phases ; Reversed-phase HPLC ; Methylbenzo(a)pyrene isomers ; Monohydroxybenzo(a)pyrene isomers ; Length-to-breath ratio of PAHs ; Comparison of HPLC and GC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The use of two nematic liquid crystals (BABT and BPhBT) as GC stationary phases for the separation of monohydroxybenzo(a)pyrenes. as their TMS ethers, and monomethylbenzo(a)pyrenes was developed and compared with the separation of these isomers by HPLC using a polymeric ODS reversed-phase column. It was found that while HPLC and GC gave comparable separation of the hydroxy isomers, 10 out of 12 separated, better separation of the methyl isomers was obtained using HPLC. A simultaneous use of both HPLC and GC would resolve the twelve hydroxy isomers in about 70min. The results indicated that HPLC, using polymeric reversed-phase columns, is as powerful a tool as GC using nematic liquid crystal phases, for the separation of benzo(a)pyrene isomers. A discussion of the effect of solute length-to-breadth ratio on elution order is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02291107
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of electric field strength, buffer type and concentration on separation parameters in capillary zone electrophoresis (1991)
    Springer
    Chromatographia 32 (1991), S. 155-161 
    Details
    ISSN: 1612-1112
    Keywords: Capillary zone electrophoresis ; Optimization of resolution ; Applied voltage ; Buffer concentration ; Buffer type ; Electroosmotic mobility ; Electrophoretic mobility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Probe solutes were used to investigate the effect of buffer type, concentration and applied voltage on solute mobility, column efficiency and resolution in capillary zone electrophoresis. With low conductivity buffers higher concentrations and/or higher voltages could be used to improve column efficiency and resolution. Doubling the concentration of the buffer doubles the amount of heat generated inside the column while doubling the applied voltage cause a 4-fold increase. Solute migration time is approximately an inverse function of the charge density of the buffer's cation. Analysis time is increased by about 30% if the buffer concentration is doubled while it is cut in half if the applied voltage is doubled. Column efficiency is improved (higher theoretical plate count) with increasing buffer concentration and/or applied voltage as long as the heat generated is efficiently dissipated. The separation factor is directly related to analysis time and, therefore, selectivity improves with increasing buffer concentration but decreases with increasing applied voltage. Hence, resolution is optimized by increasing buffer concentration at a moderate applied voltage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02325019
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of organic solvents on solute migration and separation in capillary zone electrophoresis (1993)
    Springer
    Chromatographia 35 (1993), S. 497-502 
    Details
    ISSN: 1612-1112
    Keywords: Capillary zone electrophoresis ; Organic buffer additives ; Electroosmotic mobility ; Electrophoretic mobility ; Buffer viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The effect of organic modiffers on mobility and selectivity in capillary zone electrophoresis was investigated. Test solutes having different functionalities were electropherographed at acidic and neurral pH with aqueousorganic buffers. The results show that the electroosmotic mobility is mainly influenced by buffer viscosity. The role of the dielectric constant, ζ-potential and modifier-capillary wall interactions, which may be significant at trace levels of organic modifier, is very much diminished as the organic content is increased. Buffers having equivalent viscosities generate similar electroosmotic mobilities irrespective of the type and percentage of the organic modifier. Solute electrophoretic mobility is affected similarly because of the identical nature of the forces responsible for the electroosmotic and electrophoretic flow phenomena. However, solute electrophoretic mobility is also influenced by the degree to which the organic modifier affects the equilibrium that generates the electrophoretically-active solute ions. As a consequence, the order of elution of organic content. The separation of weakly-hydrophilic solutes is improved with increasing organic proportions. The separation of dipeptides first improved with the addition of up to 15% ACN, then deteriorated with further increase of ACN proportion. An example showing change in migration order and peak cross-over is presented and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02267906
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of the gas-chromatographic properties of mesomorphic polymeric stationary phases (1989)
    Springer
    Chromatographia 27 (1989), S. 436-440 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Liquid crystal stationary phases ; PAH ; FAME ; Mesomorphic polysiloxane phases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The gas-chromatographic properties of two mesomorphic polysiloxane (MEPSIL) stationary phases, one smectic (SB) and the other nematic (N), were investigated. The retention indices and separation factors (relative retentions), α, of several pairs of polycyclic aromatic hydrocarbon (PAH) and fatty acid methyl ester (FAME) isomer solutes were used to gauge differences in the selectivity provided by each. The heats of solution of the PAH showed that the smectic MEPSIL is more selective for solutes with different length-to-breadth ratios. Also, five peaks were resolved for sixcis andtrans octadecenoic FAME isomers with this solvent. The nematic MEPSIL, on the other hand, was found to be more useful at higher temperatures because of its higher clearing point. In addition, solute capacity factors were smaller than those observed with the smectic MEPSIL, as evidenced by lower retention indices. The former was therefore more useful for the analysis of high molecular-weight PAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02319560
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