ISSN:
1436-2813
Keywords:
oesophageal cancer
;
surgical stress
;
α-human atrial natriuretic polypeptide (α-hANP)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The present study examined the effects of subtotal oesophagectomy through a right thoracal and abdominal approach, on the postoperative water-electrolyte metabolism and cardio-pulmonary function of patients with thoracic oesophageal carcinoma. The primary water balance, total sodium intake, urinary NAG index, free-water clearance (CH2O), oxygen diffusion function of the lungs to aerate blood (DLO 2-Index), and α-human atrial natriuretic polypeptide (α-hANP) were measured perioperatively until the seventh day. Subjects were divided by age according to whether they were older or younger than 70 years into 2 groups. In both groups, no change was observed in the primary water balance, total sodium intake, urinary NAG index or CH 2 O. However, all of the patients in the older group exhibited significantly higher α-hANP values than those in the control group, and the DLO 2-Index was also higher in the former subjects during the first 3 days following surgery. It may be concluded that α-hANP is a hormone of considerable importance as it is secreted in large amounts in response to increased stress on the cardio-pulmonary system and serves to normalize the water balance causing this extra load.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02471007
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