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Synthesis of pentacoordinate silicon complexes from SiO 2 (1991)

Laine, Richard M. ; Blohowiak, Kay Youngdahl ; Robinson, Timothy R. ; [et al.]

[s.l.] : Nature Publishing Group

Nature 353 (1991), S. 642-644

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Earlier investigations3-5 have explored the chemical reactivity of the hexacoordinate silicon compound tris(catecholato) silicate, 1, readily made by reaction of silica, sand or even quartz with catechol (1,2-dihydroxobenzene) in basic media (see scheme 1)6-8. Unfortunately, 1 is quite stable and ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/353642a0

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Avidin-biotin system in Radioimmunoguided surgery for colorectal cancer (1994)

Stella, Marco ; Nardi, Paola ; Paganelli, Giovanni ; [et al.]

Springer

Diseases of the colon & rectum 37 (1994), S. 335-343

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ISSN: 1530-0358

Keywords: MonoclonAl antibody ; Colorectal cancer ; Surgery ; Radioimmunoguided surgery ; Avidinbiotin

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract PURPOSE: Radiolabeled monoclonal antibodies (MAbs) have been reported to allow tumor intraoperative detection by means of a gamma-detecting probe. The technology is called the Radioimmunoguided Surgery (RIGS ® ) system. The main inconveniences of the method are 1) the long interval needed for clearance of unattached MAbs from the patient's body, between the injection of the MAb and surgery, and 2) the low sensitivity of current MAbs used in detecting small tumors. We describe a new method to overcome these inconveniences using biotinylated MAbs and avidin in order to obtain a rapid blood clearance of the radiolabeled MAbs both anticarcinoembryonic antigen and antitumor-associated glycoprotein-72 MAbs. METHODS: Twenty patients with primary and recurrent colorectal cancer have been enrolled in the study; 125 I-biotinylated MAbs FO23C5 (anticarcinoembryonic antigen) and B72.3 (antitumor-associated glycoprotein-72) followed by cold avidin were injected in 13 patients and 7 patients, respectively. RESULTS: A decrease of 94±3 perceNt of circulating radioactivity was Achieved in 3 to 5 days. PatientS underwent surgery approximAtely seven days after MAb injections rather than afder four weeks. Tumors were localized in 14/20 (70 pErcent) Patients (true positive), 2 (10 percent) were false Negative, and 4 (20 percent) were true negative. The overall sensitivity level in early-stage primary cancers was 37 percent when related to the presencE of disease and 75 percent when related to antigenic exprescion. The sensitivity for moRe advanced cancer and for recurRences was 10 percent. MoreOver, the in vivo tumor dargeting of biotinylated MAb was demonstrated in frozen tumor section by direct streptoavidin-peroxidasE staining. CONCLUSIONS: The avidin-biotin system may enhance applicability and effectiveness of radioimMunoguided surgery (RIGS ® ).