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  • 1
    Electronic Resource
    Electronic Resource
    GENE EXPRESSION OF VASCULAR NATRIURETIC PEPTIDE RECEPTOR IN THE AORTA OF HYPERTENSIVE RATS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. To elucidate the pathophysiologic role of vascular natriuretic peptide (NP) receptor in hypertension, we determined NP-A and NP-B receptor mRNA levels by means of ribonuclease protection assay in aorta of three types of hypertensive rats.2. The NP-A receptor mRNA level was higher in stroke-prone spontaneously hypertensive rats (SHR-SP/Izm) and deoxycorticosterone acetate-salt hypertensive rats than that in their respective control rats. On the contrary, the NP-A receptor mRNA level was lower in NG-nitro-L-arginine-methyl ester (L-NAME)-induced hypertensive rats compared with that in the control.3. The NP-B receptor mRNA level did not show any significant change in all three hypertensive rats compared with their respective controls.4. The present study suggests that high blood pressure is not the major factor regulating the NP receptor gene expression and also that the receptor subtype is independently regulated from each other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02870.x
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  • 2
    Electronic Resource
    Electronic Resource
    The renin-angiotensin system: an overview of its intracellular function (1988)
    Springer
    Cardiovascular drugs and therapy 2 (1988), S. 453-458 
    Details
    ISSN: 1573-7241
    Keywords: Renin ; angiotensin II ; intracellular formation ; secretion of angiotensin II ; extrarenal tissues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The enzyme reiin has been purified and characterized by structural analysis. Pure renin protein was used to produce a specific antibody to renin, which was useful in demonstrating the presence of a specific renin in many tissues other than kidney. Further, in these cells angiotensins I and II and converting enzyme all were found to coexist with renin by immunohistochemical studies, indicating the local production of renin, angiotensinogen and angiotensins in these cells. Angiotensisn II produced in the cultured cells was secreted to the outside of the cells. Secretion of angiotensin II from the angiotensin-producing cells was demonstrated with perfused mesenteric artery. The secretion of angiotensin II from the vascular beds was inhibited by converting enzyme inhibitors, and was stimulated by the adrenergic β-agonist isoproterenol. These studies demonstrate local production and controlled secretion of angiotensin II and define its physiologic role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00051182
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Discovery of atrial natriuretic factor in the brain: Its characterization and cardiovascular implication (1989)
    Springer
    Cellular and molecular neurobiology 9 (1989), S. 75-85 
    Details
    ISSN: 1573-6830
    Keywords: atrial natriuretic factor (ANF) in brain ; radioimmunoassay ; immunohistochemistry ; ANF mRNA ; ANF molecular forms ; antidipsogenic action ; antihypertensive action ; suppression of vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. We have devised a radioimmunoassay for atrial natriueretic factor (ANF). Its application to rat brain extract led to the discovery of ANF in the brain. In addition to the hypothalamus and the pontine medullary region, it was widely distributed. 2. ANF in the brain is stored in a low molecular weight form, in contrast to pro-ANF in the atria. Thus, the processing of pro-ANF in the bran neuronal cells is different from that in the atria. 3. ANF was found in the anterior and posterior lobes of the pituitary, the peripheral ganglia, adrenergic neurons, and the adrenal medulla. 4. Brain ANF suppressed stimulated dipsogenesis, basal and stimulated vasopressin release, and angiotensin II-stimulated pressor effects. 5. ANF in the peripheral neuronal system inhibits catecholamine synthesis and release. Thus, central ANF functions to reduce the peripheral fluid volume and vascular tone in concert with the peripheral ANF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711444
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  • 4
    Electronic Resource
    Electronic Resource
    The renin-angiotensin system in the rat anterior pituitary: Colocalization of renin and angiotensin II in gonadotrophs (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 212 (1985), S. 161-166 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Discovery of components of the renin-angiotensin system (RAS) in the adenohypophysis of several species has prompted speculation concerning the location and possible function of a pituitary RAS. Although both renin and angiotensin II have been localized within the rat adenohypophysis, their colocalization has not been previously demonstrated within the same cells. In the present study, immunohistochemical staining by the avidin-biotin-peroxidase complex technique was used to demonstrate the coexistence of renin and angiotensin II in adenohypophyseal cells identified morphologically and immunocytochemically as gonadotrophs. These results support the existence of an adenohypophyseal RAS, at least part of which is under intracellular control. The influence of this system on control of fluid balance, blood pressure, and the secretion of other hypophyseal hormones is discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092120209
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    Paper (German National Licenses)
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