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  • 1
    Electronic Resource
    Electronic Resource
    Solubility Enhancement of Nucleosides and Structurally Related Compounds by Complex Formation (1994)
    Springer
    Pharmaceutical research 11 (1994), S. 398-401 
    Details
    ISSN: 1573-904X
    Keywords: molecular complex ; niacinamide ; pyridoxine ; association constant ; solubility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Water-soluble vitamins, amino acids, and nontoxic pharmaceutical excipients were studied as solubilizing agents for poorly water-soluble adenine (nucleic acid base), guanosine (nucleoside), and structurally related drugs (acyclovir and triamterene). The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, or other ligand). Apparent association constants (K a ) values were measured at 25°C in pH 7 phosphate buffer using phase solubility analysis. The effect of combination ligands on substrate solubility was also studied. Additive solubility enhancement was obtained for several ligand pairs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018913104383
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Development of a Microwave Fluid-Bed Processor. I. Construction and Qualification of a Prototype Laboratory Unit (1992)
    Springer
    Pharmaceutical research 9 (1992), S. 1487-1492 
    Details
    ISSN: 1573-904X
    Keywords: microwave dryer ; fluid-bed dryer ; process equipment validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The static bed- and planetary-type microwave dryers currently available to process pharmaceutical materials are not designed to use hot-air fluidization for the purpose of maximizing microwave energy inputs and particle drying. To take advantage of the benefits offered by fluidization, a 1-kg Uni-Gatt laboratory fluid bed processor was modified to support microwave-assisted fluid bed drying of several representative pharmaceutical granulations. The construction, design features, and validation of this new microwave fluid bed processor are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015875300053
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The Development of a Microwave Fluid-Bed Processor. II. Drying Performance and Physical Characteristics of Typical Pharmaceutical Granulations (1992)
    Springer
    Pharmaceutical research 9 (1992), S. 1493-1501 
    Details
    ISSN: 1573-904X
    Keywords: microwave dryer ; fluid-bed dryer ; process equipment validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Four typical pharmaceutical granulations were used to measure the enhanced drying performance of a laboratory-sized microwave fluid-bed processor, the design and construction of which were presented in Part I of this work (preceding paper). Results demonstrate improvements in observed drying rates by as much as sixfold depending upon the granulation type and drying conditions. At a low inlet temperature (30°C), drying was achieved with microwave power inputs of 100–125 W/liter of working capacity, whereas similar targeted moisture levels were unattainable using conventional fluid-bed drying. Microwave energy available for heating and drying was 68 to 86% of the total microwave energy inputted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015827416892
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    lontophoretic Transport of a Homologous Series of Ionized and Nonionized Model Compounds: Influence of Hydrophobicity and Mechanistic Interpretation (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 85-90 
    Details
    ISSN: 1573-904X
    Keywords: iontophoresis ; facilitated transport ; ion transfer ; iontophoretic mechanisms ; electroosmosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract An in vitro study was carried out to elucidate the mechanisms controlling iontophoretic transport. The investigation focused on three areas, including the nature of the permeant (state of ionization and hydrophobicity), skin structures (hair follicle distribution and stratum corneum), and various parameters influencing iontophoresis (current, permeant concentration, and competitive ion effects). The data indicate that iontophoretic-facilitated transport is essentially pore mediated and that the transport of ionized and nonionized molecules may be enhanced through the pore-type pathway. The data presented show that iontophoresis has a detrimental effect on the lipoidal transport pathway and that the transport of more hydrophobic nonionized molecules is decreased compared with passive diffusion. The iontophoretic enhancement values decreased linearly with increasing alkyl chain length of n-alkanols. The iontophoretic permeability coefficients of ionized n-alkanoic acids was shown to decrease with increasing permeant hydrophobicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015812005467
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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