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  • 1
    Electronic Resource
    Electronic Resource
    Fasting or dexamethasone treatment reduce protease content in rat lung mast cells and modulation of histamine synthesis by H3 receptors (1994)
    Springer
    Inflammation research 42 (1994), S. 7-12 
    Details
    ISSN: 1420-908X
    Keywords: Rat mast cell proteases ; Histamine presynaptic receptor ; Dexamethasone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The sensitivity of mast cells to H3-receptor modulation was studied in rat lung under various hormonal conditions. The heterogeneity of mast cell subpopulations in rat lung was assessed by the tissue content of rat mast cell protease I (RMCP I) and rat mast cell protease II (RMCP II). After 24 h fasting, concentrations of RMCP I were unchanged whereas the concentration of RMCP II was significantly reduced by 49%. The [3H]histamine (HA) synthesis was concomitantly decreased by 35%. In addition, the modulation of [3H]HA, synthesis by the H3 receptor agonist, (R)α-methylHA and by the antagonist, thioperamide, observed in control rats, was lost in fasted rats. Single and repeated, administrations of dexamethasone did not influence RMCPI concentrations, but decreased the concentrations of RMCP II with a parallel decrease in [3H]HA synthesis. The inhibitory effect of (R)α-methylHA on [3H]HA synthesis was also reduced. These results suggest that a subpopulation of RMCP II-containing mast cells, very sensitive to environmental factors, could be the mast cells synthesizing HA in an H3-receptor-dependant manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02014292
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 399-417 
    Details
    ISSN: 1435-1463
    Keywords: Rat mast cell protease I ; rat mast cell protease II ; experimental allergic encephalomyelitis ; histaminergic neurons ; histamine H3 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mast cell populations were identified within brain parenchyma by their specific proteases, using antibodies for immunohistochemistry and ELISAs, and riboprobes were developed for in situ hybridisation. Connective tissue mast cells expressing rat mast cell protease I (RMCPI) mRNA and immunoreactivity were observed in thalamus and showed no degranulation at 3, 8 and 13 days after induction of experimental allergic encephalomyelitis (EAE). Mucosal-like mast cells were clearly demonstrated in control rats by measuring RMCPII and by visualising cells expressing RMCPII mRNA and immunoreactivity. At day 13, but not 3 and 8 post immunisation, the number of RMCPII-expressing cells markedly increased in the EAE-induced group, mainly within brainstem and spinal cord close to inflammed blood vessels. The markers of histaminergic neurons were marginally affected 13 days after immunisation and the increase of [3H] histamine synthesis elicited by the H3-receptor antagonist, thioperamide, was not modified in any region of the brain. It is concluded that the cerebral RMCPII-expressing mast cells could play a role during EAE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277659
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Concomitant detection of mucosal mast cells and eosinophils in the intestines of normal and nippostrongylus-immune rats (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 585-589 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The granules of mucosal mast cells (MMC) in the rat and man apparently poorly fixed with formaldehyde and special fixation techniques are normally used to demonstrate MMC glycosaminoglycans (GAG) in these two species. However such techniques do not permit the study of MMC granule enzyme cytochemistry or the demonstration of eosinophils. We have, therefore, examined some histochemical and immunocytochemical properties of MMC and eosinophils in normal and parasitised rats following various fixation procedures. Immersion fixation of rat intestine in 4% paraformaldehyde for 6 h not only facilitated the demonstration of MMC glycosaminoglycans with basic dyes but also permitted the concomitant staining of cosinophils with acidophilic dyes. A MMC granule-associated serine esterase was also demonstrated by enzyme cytochemistry and rat mast cell protease II was detected within MMC granules by immunocytochemistry. This new methodology obviates the requirement for separate fixation procedures in the identification and characterisation of MMC/eosinophil interactions in normal and parasitised rat intestinal mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489539
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mucosal mast cells are functionally active during spontaneous expulsion of intestinal nematode infections in rat (1984)
    [s.l.] : Nature Publishing Group
    Nature 312 (1984), S. 450-452 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Following oral infection of PVG rats with 1,500 T. spiralis muscle larvae, most adult worms were expelled from the intestine between 9 and 12 days after infection (Fig. 1), elimination being complete by day 15. Mucosal mastocytosis commenced on day 6 and was maximal at day 12 (Fig. 1). No RMCP II ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/312450a0
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    Paper (German National Licenses)
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