Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of cationic gold-iridium clusters. Structure of [IrAu2(H)(PPh3)4NO3]BF4 (1985)
    s.l. : American Chemical Society
    Inorganic chemistry 24 (1985), S. 182-187 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00196a013
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and x-ray crystal structure of [(dppe)2IrAuPPh3](BF4)2 (1985)
    s.l. : American Chemical Society
    Inorganic chemistry 24 (1985), S. 233-235 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00196a024
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Iron(III)-catalyzed oxygenation of catechols. Structure of (nitrilotriacetato)(3,5-di-tert-butylcatecholato)ferrate(III) dianion (1984)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 8312-8313 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00338a061
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model (1994)
    Springer
    Diabetologia 37 (1994), S. 1178-1185 
    Details
    ISSN: 1432-0428
    Keywords: Key words Transgenic mice ; tolerance ; insulin ; analogue ; immunogenicity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transgenic mice with tissue-specific expression of the human insulin gene in the beta cells of the pancreas do not produce insulin-specific antibodies when injected with human insulin. Tolerant transgenic mice injected with human or porcine insulin reflect the clinical situation. When injected with bovine insulin the transgenic mice produce antibodies. The potential immunogenicity of 12 recombinant human insulin analogues has been tested in this transgenic model. The analogues were designed either to prevent hexamer formation or to improve chemical stability or both. The analogues have amino acid substitutions or deletions at residue 8, 10 and 21 in the A-chain and residue 3, 9, 27 and 28 in the B-chain. The results show that substitution of single amino acids in the A-chain loop of human insulin for the corresponding amino acids in bovine insulin at residues A8 or A10 is sufficient to elicit an antibody response in responder mice. Only human insulin analogues with substitutions at residues 8 or 10 in the A-chain elicit antibody formation in the transgenic mice, whereas non-transgenic control groups respond to insulin and all analogues. Antibodies developed against the human insulin analogues are cross reactive with recombinant human insulin. Antibodies developed against an immunogenic analogue could therefore neutralize both the analogue and the native insulin and thereby aggravate the patient's condition. This transgenic mouse immunogenicity model should be useful as an in vivo model to map immunogenic areas of recombinant proteins. [Diabetologia (1994) 37: 1178–1185]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399790
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model (1994)
    Springer
    Diabetologia 37 (1994), S. 1178-1185 
    Details
    ISSN: 1432-0428
    Keywords: Transgenic mice ; tolerance ; insulin ; analogue ; immunogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transgenic mice with tissue-specific expression of the human insulin gene in the beta cells of the pancreas do not produce insulin-specific antibodies when injected with human insulin. Tolerant transgenic mice injected with human or porcine insulin reflect the clinical situation. When injected with bovine insulin the transgenic mice produce antibodies. The potential immunogenicity of 12 recombinant human insulin analogues has been tested in this transgenic model. The analogues were designed either to prevent hexamer formation or to improve chemical stability or both. The analogues have amino acid substitutions or deletions at residue 8, 10 and 21 in the A-chain and residue 3, 9, 27 and 28 in the B-chain. The results show that substitution of single amino acids in the A-chain loop of human insulin for the corresponding amino acids in bovine insulin at residues A8 or A10 is sufficient to elicit an antibody response in responder mice. Only human insulin analogues with substitutions at residues 8 or 10 in the A-chain elicit antibody formation in the transgenic mice, whereas non-transgenic control groups respond to insulin and all analogues. Antibodies developed against the human insulin analogues are cross reactive with recombinant human insulin. Antibodies developed against an immunogenic analogue could therefore neutralize both the analogue and the native insulin and thereby aggravate the patient's condition. This transgenic mouse immunogenicity model should be useful as an in vivo model to map immunogenic areas of recombinant proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399790
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Variations in insulin responsiveness in rat fat cells are due to metabolic differences rather than insulin binding (1983)
    Springer
    Diabetologia 24 (1983), S. 131-135 
    Details
    ISSN: 1432-0428
    Keywords: Insulin responsiveness ; rat fat cells ; glucose metabolism ; insulin binding ; VMH lesion ; diabetes ; obesity ; insulin resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin resistance was studied by comparing insulin response and insulin binding in four groups of rats. Glucose metabolism in isolated fat cells from male Wistar rats weighing 340 g was less responsive to a supramaximal dose of insulin than glucose metabolism in fat cells from rats weighing 200 g. Induction of streptozotocin-diabetes in rats weighing 200 g resulted in a marked decrease in the insulin responsiveness of fat cells. Ventromedial hypothalamic lesions of 340 g rats had the opposite effect and restored the insulin responsiveness of fat cells. The responsiveness in the four groups was correlated to the rate of glucose conversion to fatty acids in fat cells. The binding of 125I-insulin was the same in both 340 and 200 g rats. The ventromedial hypothalamic lesioned rats and the diabetic rats showed, in spite of their great difference in insulin responsiveness, the highest binding of 125I-insulin to fat cells. Insulin binding was not correlated to the plasma insulin level which however was reflected in the lipoprotein lipase activity in the adipose tissue. In conclusion, these results indicate that variations in insulin responsiveness in fat cells are due to alterations in cellular metabolism rather than in insulin binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297396
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Ultrasound examination of the small bowel: comparison with enteroclysis in patients with Crohn disease (1995)
    Springer
    Abdominal imaging 20 (1995), S. 323-326 
    Details
    ISSN: 1432-0509
    Keywords: Small bowel disease, US ; Crohn disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Screening for inflammatory small bowel disease has hereto relied on barium examination, usually performed after duodenal intubation. A noninvasive technique for imaging of the small bowel in such patients would be preferable. Methods A total of 59 patients were included in the study. A small bowel barium examination (SBE) was performed after duodenal intubation using a barium and air double-contrast technique. Ultrasound (US) of the right lower quadrant was performed with a 3.5- or 5-MHz transducer. The patients fasted overnight. Results In 37 of 39 patients with a normal SBE, US was also normal. In 20 patients, SBE showed lesions compatible with Crohn disease and in 18 of these the US study showed thickening of the bowel wall. One of these patients later tested positive for Yersinia enterocolitica. There were two false-positive and two false-negative US examinations. For detection of inflammatory disease of the small bowel, US was calculated to have a sensitivity of 0.95, specificity of 0.93, accuracy of 0.93, predictive value of a positive test was 0.90, and a predictive value of a negative test was 0.95. Conclusions US, therefore, seems to be a reliable method in the workup of patients suspected of having inflammatory small bowel disease. Thereby, US probably can select patients for SBE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203364
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Heterogeneous population growth, parental effects and genotype–environment interactions of a marine oligochaete (1997)
    Springer
    Marine biology 130 (1997), S. 181-191 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cultures of asexually reproducing populations of the oligochaete Paranaislitoralis (Müller) collected from six different patches (3 to 50 m apart) on an intertidal mud flat in Flax Pond, New York, on two occasions, June and October 1993, showed significant differences among lines in life span, number of offspring produced, and in finite rate of increase (λ). Although growth rates were significantly lower in October than in June, they were always positive (λ 〉 1) in the laboratory cultures reared in field-collected sediment, while field data show that the densities of P. litoralis decreased sharply in summer and autumn from a seasonal high in early June. Cultures of worms reared at high densities without renewal of sediment crashed, and effects on individuals were irreversible: worms from late (declining) stages of population growth had a significantly higher mortality and lower reproduction than worms from earlier stages, also when transferred to high-quality food. Genetical analysis using RAPDs (random amplified polymorphic DNA) confirmed the existence of several clones of P. litoralis in our cultures. Experiments where parent and offspring were cultured in sediments of different qualities showed clone–environment interactions in the number of asexual offspring produced, but not in age at first reproduction. Clones also differed in that some showed significant parental effects of sediment quality on life-history characteristics while other clones did not. Our results indicate that P.litoralis populations in Flax Pond are not an example of a population subdivided into a set of permanent source and sink subpopulations, but rather an example of a continuously shifting mosaic of local growth conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050237
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Aseptic cultivation of higher plants (1957)
    Springer
    Archives of microbiology 26 (1957), S. 285-301 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A short survey of different problems connected with the aseptic cultivation of higher plants is given. Accounts have been given of experiments in which antibiotics and fungicides have been used, as well separately as in combination, as surface-sterilizing agents. The use of chlorine as a sterilizing agent for the surface-sterilization of pea seed has been investigated and an account given of the importance of damage to the skin of the seed in the procedure. Procedures for the surface sterilization of oats and barley, and for pea seed, have been developed. Various arrangements in which the aseptic cultivation of higher plants may be carried out are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409045
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    New sonographic imaging observations in focal pancreatitis (1999)
    Springer
    European radiology 9 (1999), S. 862-867 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Pancreatitis ; Ultrasound ; Pancreatic tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The imaging findings that ultrasonographically differentiate focal acute pancreatitis (FAP) from a malignant lesion of the pancreas are described. Focal acute pancreatitis is ultrasonographically (US) characterized as a hypoechoic, homogeneous, localized, subsegmental, non-expansive and diffusely demarcated lesion located mostly in the head of the pancreas. It could not be visualized using CT. Endoscopic retrograde cholangiopancreatography (ERCP) performed in 13 of the 32 patients, showed chronic pancreatitis. Focal acute pancreatitis disappeared in 1–6 months at US follow-up. The clinical diagnoses were acute pancreatitis in 11 patients, chronic pancreatitis in 12 patients, biliary disease in 5 patients, hepatopathia in 1 patient while the diagnosis was unknown in 2 patients. No patient developed any pancreatic cancer during a median of 85 months of follow-up. In conclusion, the present data indicate that patients with FAP at US, without any focal lesion seen on either CT or ERCP, have a benign pancreatic lesion, which resolves in 1–6 months; thus, such patients probably do not need any further investigation or follow-up at all.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050756
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...