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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 18 (1985), S. 55-57 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A number of human telomeres have been successfully cloned using a modified yeast artificial chromosome (YAC) vector (half-YAC) cloning strategy, but to date, human chromosome 22q has not been identified by this approach. We used an alternative approach of genomic walking, starting from a subtelomeric sequence, TelBam3.4, present on a number of human chromosomes including 22q. This approach was successful in the development of a cosmid contig representing the terminal 140 kb of human chromosome 22q, providing telomeric closure of the genetic and physical maps for 22q. The most distal region of the contig contains subtelomeric repeats which crosshybridize to a number of chromosomes, while the proximal sequences are unique for 22q. The unique sequence cosmid was used as a 22qter-specific probe for fluorescence in situ hybridization (FISH) analysis, which confirmed that this cosmid was distal to the most telomeric marker previously available for chromosome 22. In addition, this cosmid was used to document a 22q terminal deletion that was not detectable by conventional cytogenetic analysis. Unique telomere-specific FISH probes such as this one will have significant diagnostic value in the detection of cryptic deletions and translocations in patients with unexplained mental retardation and other patient populations.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Unbalanced translocations are a frequent cause of multiple congenital anomalies in children. Translocations as small as 2–5 Mb of DNA are detectable by G-banding under optimal conditions. Some of these small translocations are visible but cannot be characterized cytogenetically due to the lack of characteristic banding on Giemsa preparations. We have combined chromosomal microdissection and fluorescence in situ hybridization (FISH) to identify the origin of a small translocated segment in three members of a family with a derivative chromosome 9 and multiple anomalies, including several ophthalmologic anomalies. We microdissected the abnormal region of the derivative 9 chromosome and used this DNA to generate a FISH probe. This probe hybridized to distal 10p on the metaphase spread of the proband, indicating the origin of the translocated segment. A whole 10p FISH probe confirmed the origin by hybridizing to the translocated segment of the derivative chromosome. FISH was then performed with a whole chromosome 9 painting probe and excluded the presence of a reciprocal, balancing translocation. We then studied the chromosome 10 partial duplication with microsatellite markers to better characterize the chromosomal segment that caused these phenotypic features. By examining the involved areas with distal 10p and 9p microsatellite markers, we were able to demonstrate a minimum of 9 Mb of trisomic 10p DNA with a chromosomal breakpoint between 10p14– 10p15. We then compared this family’s clinical findings to those of individuals with partial 10p trisomy who had been reported in the literature. The clinical phenotypes seen in this family are similar to, but milder than, the phenotypes of persons with the larger partial trisomies of 10p that were diagnosable by cytogenetic analysis alone. This study shows that microdissection and DNA markers can be used to precisely define small translocations that are difficult to identify by conventional G-banded chromosome analysis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Genomics 16 (1993), S. 758-760 
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research DNAging 256 (1991), S. 303-310 
    ISSN: 0921-8734
    Keywords: Cellular senescence ; Immortalization ; Microcell hybrids
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Genomics 17 (1993), S. 770-772 
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Experimental Gerontology 27 (1992), S. 519-522 
    ISSN: 0531-5565
    Keywords: HeLa ; cell fusion ; cellular aging ; limited doubling potential ; senescence
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2698-2701 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: When using a multimode fiber lead in an optical current measurement system, the optical power in the guided modes is often determined by the coupling conditions at the input end of the fiber. If only the skew rays are excited in the fiber lead—under appropriate coupling conditions—the vibration-induced noise normally experienced in the fiber lead in such an optical current measurement system can be effectively suppressed, especially when a low coherence source and a long length of multimode fiber is used. The experimental conditions for this are considered and discussed in this article. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 1961-1965 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A novel hybrid interferometer stabilization scheme used for wavelength shift measurement, such as for in-fiber Bragg grating-based sensors, is described. This scheme combines the advantages of the long term optical imbalance stability offered by the locking system used and a comparative insensitivity to vibration-induced noise at frequencies up to 200 Hz, achieved with the use of a so-called "detection-and-compensation" scheme. By including an additional reference beam and the hybrid interferometer stabilization scheme, the vibration-induced fluctuation in the signal can be reduced by about 20 dB, and the value of the phase variation can be reduced by a factor of 20. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 3097-3111 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper reviews recent developments in the field of current measurement which employ a wide range of optical and fiber optic techniques. Depending on the current sensing mechanisms involved and the sensing materials used, optical current sensors (OCSs) may be categorized into four main groups: (i) OCSs employing optical fiber as their sensing elements, (ii) OCSs using bulk glass to sense the current, (iii) OCSs using electro-optic hybrid sensing devices, and (iv) OCSs using magnetic field sensing devices. The operational modes of a variety of OCSs have been grouped and discussed, and several examples given. It can be seen that as a result of an intensive and wide ranging research effort using various approaches, substantial progress in the differing aspects of the optical current sensing techniques considered, such as the sensing material used, the configurations of sensing elements introduced, and the detection schemes adapted, has been achieved during the past years. An overall view of the field shows it to be as an active and exciting research area, highlighting several recently introduced and novel sensing materials and configurations which provide impressive results in this field of instrumentation. Examples of applications for the electric power industry are discussed more extensively. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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