ISSN:
1432-0533
Keywords:
Synapse
;
Locus ceruleus
;
Parkinson's disease
;
Alzheimer's disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have studied the synaptic ultrastructure in human autopsy material from the locus ceruleus, an important noradrenergic center. Ten cases of Alzheimer's disease, ten cases of Parkinson's disease, and ten control brains were examined. Only a few differences in synaptic morphology between the three groups were found. Multiple symmetrical and asymmetrical contacts on medium-sized dendrites were characteristically present. Axosomatic synapses were also common. In Alzheimer's disease axosomatic synapses on nerve cell perikarya containing neurofibrillary tangles, and in Parkinson's disease on perikarya containing Lewy bodies, could be demonstrated. Dendritic spines were rare, but the control group had structures interpreted as “minispines”. In agreement with studies in the rat, cat, and rabbit, no spine apparatus was present, but in contrast to those studies no somatic spines were identified. Rare axoaxonic synapses were found in the control group. Vesicle content was often pleomorphic with flattened vesicles. Large dense core vesicles were present in variable numbers in nerve cell processes, and large accumulations of such vesicles were seen in two thirds of our cases, most abundant in the Alzheimer's and Parkinson's disease groups. Such terminals may be aminergic, perhaps serotonergic, and may be a normal component of the locus ceruleus. Their greater abundance in Alzheimer's and Parkinson's disease may be due to accumulation of the amines in afferent terminals, which have been deprived of their postsynaptic connections due to the degenerative disease process.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00697178
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