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  • 1
    Electronic Resource
    Electronic Resource
    Enteraler Plasmaeiweißverlust („Proteindiarrhoe“) beim nephrotischen Syndrom (1963)
    Springer
    Journal of molecular medicine 41 (1963), S. 15-18 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über Ausscheidungsstudien mit PVP-I131 an 22 Patienten mit „nephrotischem Syndrom“ berichtet. Nach den vorliegenden Untersuchungsergebnissen ist die Durchlässigkeit der Darm wand für Makromoleküle bei unbehandelten und anbehandelten Patienten im Sinne einer Proteindiarrhoe erhöht. Bei länger behandelten Fällen liegen die Darmausscheidungswerte im Bereiche der Norm. Es wird gezeigt, daß Proteinurie und Proteindiarrhoe unabhängig voneinander vorliegen können. Die Bedeutung dieser Befunde für die Pathogenese der nephrotischen Hypoproteinämie wird erörtert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478612
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    IgG, IgA and IgE gliadin antibody determinations as screening test for untreated coeliac disease in children, a multicentre study (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 496-502 
    Details
    ISSN: 1432-1076
    Keywords: Diagnostic value ; Gliadin IgG, IgA, and IgE antibody determinations ; Coeliac disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The diagnostic value of gliadin IgG, IgA and IgE antibody (AB) determinations using the fluorescent immunosorbent test was examined in 586 children with malabsorptive disorders and/or failure to thrive. All patients underwent jejunal biopsy and were on a gluten-containing diet. IgG AB were found in all patients (331/331) with untreated coeliac disease (CD) in our study, but IgA AB in only 295/331 (89%). Therefore a screening test based only on IgA AB determinations is not recommended. By contrast, 203 (80%) of 255 children with other malabsorptive disorders had no gliadin AB, 43 (16.5%) had only IgG AB and only 9 (3.5%) had IgG and IgA AB. IgE AB proved to be of no additional value as a diagnostic tool because they were found in a quarter of the children without CD. Statistical evaluation of combined IgG and IgA AB determination showed at least 96% sensitivity and a specificity of 97%. The subjective (“Bayesian”) probability that an actual patient with a given AB test result has CD, is considered: a patient very probably has CD in the case of positive IgG and IgA AB, and no CD in the case of a negative AB result. In the case of negative IgA AB but positive IgG AB the physician's judgement (“prior probability”) influences the (“posterior”) probability of CD for an actual patient. In contrast to IgG AB, IgA AB decline rapidly after the introduction of a gluten-free diet and may be used for diet control after diagnosis. Antibodies against cow's milk proteins, though present in 72% of the 331 patients with CD, are of no therapeutic significance in CD and are of no value for its diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441541
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A proposition for the diagnosis and treatment of gastro-oesophageal reflux disease in children: A report from a working group on gastro-oesophageal reflux disease (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 704-711 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this paper, a Working Group on Gastro-Oesophageal Reflux discusses recommendations for the first line diagnostic and therapeutic approach of gastro-oesophageal reflux disease in infants and children. All members of the Working Group agreed that infants with uncomplicated gastro-oesophageal reflux can be safely treated before performing (expensive and often unnecessary) complementary investigations. However, the latter are mandatory if symptoms persist despite appropriate treatment. Oesophageal pH monitoring of long duration (18–24 h) is recommended as the investigation technique of choice in infants and children with atypical presentations of gastro-oesophageal reflux. Upper gastro-intestinal endoscopy in a specialised centre is the technique of choice in infants and children presenting with symptoms suggestive of peptic oesophagitis. Prokinetics, still a relatively new drug family, have already obtained a definitive place in the treatment of gastro-oesophageal reflux disease in infants and children, especially if “non-drug” treatment (positional therapy, dietary recommendations, etc.) was unsuccessful. It was the aim of the Working Group to help the paediatrician with this consensus statement and guide-lines to establish a standardised management of gastro-oesophageal reflux disease in infants and children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953980
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Childhood tuberculosis at a Swiss university hospital: A 2-year study (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 805-809 
    Details
    ISSN: 1432-1076
    Keywords: Tuberculosis ; Child ; Contact tracing ; Migrants ; Antitubercular agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidence of tuberculosis (TB) presenting to the University Hospital, Geneva, Switzerland, was studied over 2 years. Clinical data on all children receiving antituberculous drug therapy was collected. Of the 43 identified cases, 42% had active disease (i.e. clinical evidence of organ involvement), the remaining 58% being asymptomatic. All 43 children originated from countries other than Switzerland. Symptomatic, drug induced hepatitis necessitated temporary interruption of therapy in 2 children (5%). Contact screening yielded three new cases of pulmonary TB, three previously diagnosed cases and seven instances of a positive medical history in relatives living in other countries. Of the 34 families in this study, contact screening could not be completed in 8. The results of this study indicate that children with TB are primarily associated with families originating from countries other than Switzerland, particularly those in which TB remains endemic. Tuberculin skin testing should therefore be targeted at this group. Contact tracing has also been shown to be beneficial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02073375
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Robinow syndrome in two siblings from consanguineous parents (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 586-589 
    Details
    ISSN: 1432-1076
    Keywords: Robinow syndrome ; Autosomal recessive occurrence ; Chromosomal abnormalities ; Y chromosome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A Kurdish family had two children affected with Robinow syndrome. The daughter had short stature, macrocephaly, hypertelorism, hepatosplenomegaly, short forearms and marked vertebral anomalies. Her brother had hypertelorism, hypertrophied alveolar ridges, hepatosplenomegaly, short forearms, rib anomaly and ambiguous genitalia. The karyotype of the affected male sibling showed mosaicism for 45X, 46,X,dicY(q11.22), 47,X,dicY(q11.22),dicY(q11.22).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957728
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Intramural diverticulosis of the esophagus in an eight-year-old boy (1978)
    Springer
    Pediatric radiology 6 (1978), S. 235-237 
    Details
    ISSN: 1432-1998
    Keywords: Esophageal diverticulosis ; Esophageal stenosis ; Esophagitis ; Hiatal hernia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A third pediatric case of intramural diverticulosis of the esophagus is reported in an 8-yearold boy. A hiatal hernia, chronic nonspecific esophagitis and defective esophageal motility was also documented in his 10-year-old brother.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00975544
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    Paper (German National Licenses)
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