ISSN:
1432-1130
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Samples of bovine muscle, liver and urine, zeranol-free (RM 508, RM 509 and RM 510, respectively) and zeranol-containing (RM 511, RM 512 and RM 513, respectively) were prepared and tested as candidate reference materials. Preliminary studies on achievement of target zeranol content, intercomparison of analytical methods (HPLC-RIA and GC-MS) and effects of lyophilisation and irradiation on zeranol content are described. The preparation of the materials and testing for homogeneity and stability of zeranol in the materials are discussed. The coefficients of variation for zeranol determinations for between-vial homogeneity (4.0%, 4.4% and 4.6% for muscle, liver and urine, respectively) are similar to those for the analytical method (4.0%, 7.3% and 6.8% for muscle, liver and urine, respectively) indicating that the materials are homogeneous. Stability data over a 12-month storage period at temperatures ranging from −18 °C to +37 °C indicate that the materials are sufficiently stable for use as reference materials. This paper is dedicated to the memory of Dr Hilary Stevenson (The Queen’s University of Belfast/DANI) who, together with Mr. W. Graham, facilitated the irradiation of the lyophilised materials.--〉
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002160050299
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