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  • 1
    Electronic Resource
    Electronic Resource
    The effect of topical oestradiol on skin collagen of postmenopausal women (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To examine the effect of topical oestradiol on skin collagen and elastin.Subjects Twelve postmenopausal women, aged 52 to 76 years.Interventions Topical oestradiol treatment on the skin of lower abdomen and the vehicle only on the contralateral site; once a day for three months.Main outcome measures The content of skin hydroxyproline; the levels of the carboxyterminal propeptide of human type I procollagen (PICP) and of the aminoterminal propetide of human type III procollagen (PIIINP).The number and the quality of collagen and elastic microfibrils.Results The amount of hydroxyproline in the skin significantly (P= 0.012) increased from 11.8 to 16.3 pgμ(38 %) during oestradiol treatment. After treatment, the PICP level in the blister fluid was significantly (P= 0.024) higher on the treated site than on the control site. Also the level of PIIINP increased, but the change was not statistically significant. Electron microscopy showed morphologic improvement of elastic and collagen fibres, while the number of oxytalan and elaunin fibres was unchanged in light microscopy.Conclusions Topical oestradiol treatment increases the amount of skin collagen. The increase in the level of PICP and PIIINP in skin blister fluid indicates that oestradiol treatment stimulates collagen synthesis. Furthermore, our results show that topical ostradiol treatment has a greater influence on the amount than on the quality of skin collagen. On the contrary, in elastic tissue the oestradiol treatment will only result in morphologic improvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb10906.x
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  • 2
    Electronic Resource
    Electronic Resource
    The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy (2004)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Fibrosis is a common complication of radiotherapy. The pathogenesis of radiation-induced fibrosis is not known in detail. There is increasing evidence to suggest that mast cells contribute to various fibrotic conditions. Several mast-cell mediators have been proposed to have a role in fibrogenesis. Tryptase and chymase, the predominant proteins in mast cells, have been shown to induce fibroblast proliferation and collagen synthesis in vitro. In order to explore the role of mast cells in irradiation-induced fibrosis, we analyzed skin biopsies and suction blister fluid (SBF) samples from the lesional and healthy-looking skin of 10 patients who had been treated for breast cancer with surgery and radiotherapy. The biopsies were analyzed histochemically for mast-cell tryptase, chymase, kit receptor, and tumor necrosis factor-α. Skin collagen synthesis was assessed by determining the levels of type I and III procollagen amino-terminal propeptides (PINP and PIIINP) in SBF and using immunohistochemical staining for PINP. Immunohistochemical stainings for prolyl-4-hydroxylase reflecting collagen synthesis and chymase immunoreactivity in irradiated and control skin were also performed. The mean level of procollagen propeptides in SBF, which reflects actual skin collagen synthesis in vivo, was markedly increased in irradiated skin compared to corresponding healthy control skin areas. The mean number of PINP-positive fibroblasts was also significantly increased in the upper dermis of radiotherapy-treated skin. The number of cells positive for tryptase, chymase and kit receptor was markedly increased in irradiated skin. In addition, using double-staining techniques, it was possible to demonstrate that in some areas of the dermis, tryptase-positive mast cells and fibroblasts are closely associated. These findings suggest a possible role of mast cells in enhanced skin collagen synthesis and fibrosis induced by radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.00164.x
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  • 3
    Electronic Resource
    Electronic Resource
    Demonstration of cellular retinoic acid binding protein in cultured human skin fibroblasts (1985)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 113 (1985), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies have indicated that retinoids, such as all-trans-retinoic acid and 13-cis-retinoic acid, can modulate connective tissue metabolism in human skin fibroblast cultures. Such effects could be mediated through binding of these retinoids to specific cellular binding proteins. In the present study we have demonstrated cellular retinoic acid binding protein using both whole cell and cytosol binding assays with [3H]all-trans-retinoic acid or [3H]13-cis-retinoic acid as the ligand. Specific binding of [3H]all-trans-retinoic acid could be demonstrated by both techniques and the binding could be displaced by unlabelled all-trans-retinoic acid and 13-cis-retinoic acid, but not by retinol or RO-10-9359 (etretinate) in a 100-fold excess. Gel filtration chromatography of the cytosol proteins after incubation with [3H]all-trans-retinoic acid demonstrated that the specific binding protein had an apparent molecular weight of approximately 15000 daltons. Thus, the cellular retinoic acid binding protein demonstrated in human skin fibroblasts may mediate the effects of the retinoids on connective tissue metabolism in these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1985.tb02376.x
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  • 4
    Electronic Resource
    Electronic Resource
    New aspects of the mechanism of corticosteroid–induced dermal atrophy (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 16 (1991), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Glucocorticoids are effective for the treatment of various inflammatory skin diseases, but their long-term use may lead to serious side-effects such as osteoporosis and skin atrophy. The incidence of skin atrophy following application of potent corticosteroids is especially high among children and the elderly. During recent years the effects of glucocorticoids on connective tissue have been elucidated, and it is evident that skin atrophy is mostly due to a decrease in collagen synthesis. Since collagen is the most abundant protein in the skin, the inhibition of its synthesis leads to atrophy. This review discusses the molecular mechanisms of glucocorticosteroid-induced skin atrophy and therapeutic possibilities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1991.tb01225.x
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  • 5
    Electronic Resource
    Electronic Resource
    Basement membrane components and galactosylhydroxylysyl glucosyltransferase in suction blisters of human skin (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 106 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Basement membrane components and collagen biosynthesis were studied in suction blisters in human skin. The basement membrane components were characterized by immunofluorescence using specific antibodies to type IV collagen, laminin and fibronectin, and collagen biosynthesis was studied by assaying galactosylhydroxylysyl glucosyltransferase.In suction blisters, the separation of epidermis and dermis occurred above the lamina lucida, indicating that the basement membrane, composed of lamina lucida and lamina dcnsa, forms a mechanically strong entity. During the regeneration phase of blisters, type IV collagen and laminin were not observed in the old epidermal blister roof. This indicates that keratinocytes when separated from the underlying basement membrane or connective tissue do not synthesize laminin or type IV collagen.GalactosylhydroxylysyJ glucosyltransferase activity could be demonstrated in blister fluid and was about the same as in serum when expressed on the basis of protein in fresh blisters. It increased by 2–3 fold during the repair of blisters, indicating that there was local production of this enzyme. Further studies revealed that pure epidermis contained galactosylhydroxylysyl glucosyltransferase and hydroxyproline and this suggests that epidermis may synthesize some collagen type which, according to these studies, is not type IV (basement membrane) collagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb01721.x
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  • 6
    Electronic Resource
    Electronic Resource
    Steroid-induced Dermal Atrophy (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 21 (1982), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : Collagen production by human skin fibroblast cultures was studied by incubation with [3H] proline and several glucocorticosteroids known to produce dermal atrophy in vivo. Collagen production was measured as formation of [3H]hydroxyproline or collagenase-digestible3H-polypeptides, and the values were corrected for changes in cell number in the same cultures. The steroids, in a wide concentration range, failed to elicit any consistent alterations in collagen production. Review of the literature dealing with corticosteroid-induced changes in collagen production by human skin fibroblasts indicate conflicting results even under apparently similar incubation conditions. Consequently, no unifying hypothesis for steroid-induced dermal atrophy can be developed presently based on the in vitro data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1982.tb03140.x
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  • 7
    Electronic Resource
    Electronic Resource
    NONMELANOMA SKIN CANCER IN NORTHERN FINLAND (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 35 (1996), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background and Objectives. The incidence of nonmelanoma skin cancers is highest in those geographic areas where light-skinned people are exposed to large amounts of sunlight. The purpose of this study was to detect differences in nonmelanoma skin cancers diagnosed in Northern Finland compared to those from elsewhere. Another purpose was to estimate whether changes have occurred in clinical diagnosis, site distribution, and recurrence rate during the past 15 years. Methods. The material included patients treated at Oulu University Hospital in Northern Finiand (64.6°N) during the years 1976—1977 and 1991—1992. Information was collected from files on 334 patients with 428 different, histologically verified skin cancers. Results. In 1976—1977, the average age of men with basal cell carcinoma (BCC) was 61 years, whereas the women's average age was 66 years. In 1991—1992, the corresponding ages were 69 and 72 years. The site distribution did not show any obvious changes in the 15 years, but the differences between sexes had become more prominent. Men had more BCC on the ears and the trunk, whereas women had more BCC on the nose and the forehead. Most of the squamous cell carcinomas (sec) were on the head and neck similar to BCC, but on the ears of men there occurred relatively more secthan BCC. Conclusions. The clinical diagnosis of BCC was fairly easy to make, whereas that of sec seemed to be very difficult clinically and was only correct in 10% of the cases. The markedly decreased recurrence rate of BCC between 1976 and 1992 probably occurred because of changes in treatment practices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1996.tb00640.x
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  • 8
    Electronic Resource
    Electronic Resource
    DERMAL CONNECTIVE TISSUE MODULATED BY PHARMACOLOGIC AGENTS (1992)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 31 (1992), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1992.tb03916.x
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  • 9
    Electronic Resource
    Electronic Resource
    Distribution and synthesis of type VII collagen in oral squamous cell carcinoma (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 26 (1997), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of the basement membrane anchoring fibril component type VII collagen was studied in oral squamous cell carcinoma by using in situ hybridization and immunohistochemical methods. The expression of type VII collagen in oral normal mucosa, lichen planus and epithelial dysplasias was also investigated. In squamous cell carcinomas, the signals for type VII collagen raRNA were Socated exclusively in malignant peripheral cells in tumour islands and in fibro-blast-like cells among the stromal tissue. In normal buccal mucosa, type VII collagen mRNA expression was located in basal epithelial cells. In oral lichen planus and epithelial dysplasias, the signals for type VII collagen mRNA were also located in basal keratinocytes: however, the signal was especially strong in some epithelial cells. In oral squamous cell carcinomas, the linear immunohistochemical staining pattern of type VII collagen was noted surrounding partly squamous epithelial tumour cell islands, and a large number of tumour cells showed a cytoplasmic staining reaction using the type VII collagen antibody. Some fibroblast-like stromal cells also showed a positive immunostaining reaction. In conclusion, the results of this study indicate that a high synthesis level, but an impaired distribution of type VII collagen, are highly characteristic of squamous epithelial tumour cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1997.tb00241.x
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  • 10
    Electronic Resource
    Electronic Resource
    Synthesis and degradation of connective tissue macromolecules in pachydermoperiostosis (PDF): evidence for altered processing of plasminogen activator inhibitor-1 (PAI-1) (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Pachydermoperiostosis (POP) is a hereditary disease with hy-perostosis, clubbing of fingers, coarse skin and thickening of bones. Previous studies have disclosed some abnormality in the connective tissue in these patients. The purpose of the present study was to investigate connective tissue pathology in one family with PDP using libroblasl cultures. Fibroblastic cells were established from both the affected and healthy looking skin of 2 patients with PDP, and the expression of types I and III collagen, 92 kDa and 72 kDa gelatinases, metalloproteinase inhibitor (TIMP-1), human retinoic acid receptor and transforming growth factor β (TGFβ) was analyzed. The modulation of glycoprolein synthesis, and of plasminogen activators and their inhibitors by TGFβin vitro were also studied. The results indicated that collagen genes and gelatinases were similarly expressed in PDP and control cells, as well as the human retinoic acid receptor. TGF-β stimulated, both in PDP cells and normal cells, the synthesis of fibroneclin, procollagen and plasminogen activator inhibitor-1 (PAI-1), but qualitative differences could not be found. Proteolytically processed forms of PAI-1 were detected in PDP cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1995.tb00223.x
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