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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructure of uterine smooth muscle following progesterone or progesterone-estrogen treatmentSupported by USPHS grants AM-08029, HD-01357 avid HD-00606. The investigators are grateful to Dr. Norman Sulkin for making the electron microscope available. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 121-131 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The ultrastructural effect of progesterone, alone and in combination with estrogen, on smooth muscle cells of the rat uterus was studied. Adult, bilaterally ovariectomized rats were untreated (controls) or treated with either progesterone (1 mg), estrogen (1 μg) or both on three consecutive days.Uterine muscle cells appeared larger and myofilaments more abundant in the progesterone-treated rats than in the other groups of animals. Many micropinocytotic vesicles and several dense bodies were present in muscle cells of control, progesterone and estrogen-progesterone-treated rats. In the progestrone-treated group, smooth muscle cells contained little granular endoplasmic reticulum and few ribosomes and glycogen particles, similar to the controls. Mitochondria were more numerous than in the control animals but similar to those seen in the estrogen or estrogen-progesterone-treated rats. Although an accumulation of granular endoplasmic reticulum, free ribosomes, glycogen particles and extensive Golgi complexes occurred in both estrogen and estrogen-progesterone-treated rats, they were more extensive in the former group.The observations indicate that progesterone alters the ultrastructure of the smooth muscle cells but not to the degree observed following estrogen stimulation. It does not markedly inhibit the effect of estrogen on the fine structure of the uterine smooth muscle cells. These observations support previous biochemical studies on glycogen concentration, RNA and protein synthesis in the rat uterus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091630114
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  • 2
    Electronic Resource
    Electronic Resource
    Cyclic variations in the oviductal ciliated cells during the menstrual cycle and after estrogen treatment in the pig-tailed monkey, Macaca nemestrina (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 198 (1980), S. 35-57 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The epithelium of the oviduct of the pig-tailed monkey, Macaca nemestrina was studied (1) to determine whether quantitative changes in the number of ciliated, deciliated, reciliating and nonciliated cells occur during the menstrual cycle and under certain experimental conditions and (2) to describe the ultrastructure of the ciliated and ciliogenic cells. The mean percentage of ciliated cells decreased from 48.2 in the fimbriae and 48.3 in the ampullae in the postovulatory stage to 7.7 and 18.8, respectively in the late luteal phase; these changes are significant as determined by Duncan's multiple range test. In the early follicular phase 3.9% of the cells in the fimbriae and 11.2% in the ampullae are ciliated, and the number of ciliogenic (deciliated and reciliating) cells is the highest of any time in the cycle in both the fimbrial (6.3%)and ampullar (8.4%)epithelium. In contrast, although the percentage of ciliated cells in the isthmus varies from 44.4 in the preovulatory phase to 34.3 in the early follicular phase, the differences between the various times in the cycle are not significant. However, in the late luteal phase, the values for the fimbriae and ampullae are significantly different from that of the isthmi. Ciliated cells constitute less than 1% of both the fimbrial and ampullar epithelium 2 ¾ years after ovariectomy, but 16.7 in the isthmic tissue. In ovariectomized monkeys treated for 7 or 12 days with estradiol benzoate reciliation occurs, but to a significantly lesser extent in the fimbriae and ampullae than in the pre- or postovulatory animals; the degree of reciliation in the isthmus is not different from the values noted during the cycle. The ultrastructure of ciliated, deciliated and reciliating cells is described. Of much interest is the finding of cytoplasmic protrusions containing variable numbers of ciliary axonemal complexes. It is postulated that such internalization of ciliary micotubules may represent one way in which deciliation may be accomplished.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091980104
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  • 3
    Electronic Resource
    Electronic Resource
    Observations on fertilization and the first segmentation division in rat ovaThis investigation was supported by a grant from the Committee for Research in Problems of Sex, National Research Council, and the Dr. Henry C. Buswell Memorial, University of Rochester School of Medicine and Dentistry, Rochester, New York. (1951)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 89 (1951), S. 29-61 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1000890103
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  • 4
    Electronic Resource
    Electronic Resource
    The poison gland of the cottonmouth moccasin, Ancistrodon P. piscivorus, as observed with the electron microscopeThis study was intiated with the cooperation of Dr. Joseph. F. Gennaro, Jr. who provided the snakes and obtained the tissue from them. The opportunity to examine the slides used in his histological and histochemical study (1960) and his interest in this work is appreciated.This study was supported by grants E-1868, E-4515, and HD-00606 from the National Institutes of Health, United States Department of Health, Education and Welfare. (1965)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 117 (1965), S. 115-133 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The structure of the poison gland of the cottonmouth moccasin has been studied with the electron microscope. This gland is divided functionally and structurally into a posterior and an anterior portion. In the posterior gland the columnar principal cells are considered to be responsible for the production of the secretory material, including the toxic substances in the venom. This cell is characterized by numerous dilated membrane pairs of the granular endoplasmic reticulum and by a large Golgi complex. Four other types of cells are observed within the epithelial layer of the posterior part of the gland, but their function is unknown.The majority of the cells of the anterior part of the gland are mucous-secreting goblet cells. Some possible stages in their secretory cycle are described. Granular endoplasmic reticulum is present in the basal areas of the cell. The accumulation of recognizable secretory material appears first in structures considered to be a part of the Golgi complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051170107
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  • 5
    Electronic Resource
    Electronic Resource
    The ultrastructure of unilaminar follicles of the hamster ovary (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 116 (1965), S. 493-521 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Unilaminar follicles consisting of primary oocytes surrounded by a single granulosal layer, composed either of flattened, cuboidal or columnar cells, have been studied with the electron microscope in normal prepubertal hamsters. The most striking feature of the oocyte cytoplasm is the occurrence of the mitochondria in small groups with a dense intermitochondrial substance lying between the individual mitochondria. This substance is composed mainly of very small vesicles with a dense profile and a light center. Some of the mitochondria do not appear to have a limiting membrane, their matrices being seemingly continuous with, and similar in structure to, the intermitochondrial substance. In the younger oocytes the Golgi complex is diffuse and has numerous small vesicles. The nucleoli of the young oocytes are large and complex. They consist of a lighter area, predominantly of small particulate elements, and of darker regions, mainly with fine fibrillar components. The initial steps in the formation of the zona pellucida take place in follicles with a single layer of cuboidal granulosa cells. By the time the oocyte is surrounded by a single layer of columnar granulosa cells a continuous zona pellucida within which lies oocyte microvilli and granulosa cell processes is present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001160304
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  • 6
    Electronic Resource
    Electronic Resource
    Light and electron microscopic observations on ciliated vacuoles and cysts in the oviductal and endocervical epithelia of the rabbit (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 190 (1991), S. 334-348 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Ciliated vacuoles and intraepithelial cysts have been observed in oviductal and endocervical epithelia of rabbits. In this study, rabbits under various hormonal conditions were studied by light and transmission electron microscopy and tissue culture in an attempt to determine their distribution and origin. Ciliated vacuoles most frequently lay in the basal cytoplasm, below or beside the nucleus, and very close to the basal lamina. A few were apically located. Their average diameter was 8.8 by 5.1 μm. Cilia and microvilli projected into the vacuolar lumen. These vacuoles were located intracellularly as evidenced first by the degeneration of both their cilia and microvilli and the moderately dense matrix that often filled the vacuolar lumen, as observed by electron microscopy. Secondly, phase microscopy of the living endocervical epithelium allowed us to observe the beating of the cilia within the vacuoles, not on the surface of such cells. Thirdly, ruthenium red stained the surface glycocalyx of the ciliated and secretory cells, but not that of the cilia and microvilli within the vacuoles.The intraepithelial cysts were not observed in all tissue blocks. The largest numbers were found in ovariectomized animals treated for 3 and 5 days with estradiol. More were seen in the isthmus and cervix than in the fimbria and ampulla. The cysts were located most often within the epithelium along the sides of, and at the bases of, the mucosal folds. They were lined by flattened epithelium of various combinations of secretory and ciliated cells.An unusual cell type was associated with some of the cysts and ciliated vacuoles. Its cytoplasm contained aggregates of mitochondria and vesicles whose contents varied in density. Although the genesis of the ciliated vacuoles is not certain, our results indicate that they may arise from aberrant positioning of proliferating procentrioles or from a defect in targeting or transporting the centrioles to the apical plasma membrane to serve as basal bodies. Fusion of adjacent ciliated vacuoles with lumina lined by secretory cells having deep apical invaginations appeared to contribute to the formation of cysts.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001900403
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  • 7
    Electronic Resource
    Electronic Resource
    The temporal relationship of the first maturation division of rat ova to the onset of heatThis study was supported by grant RG-3118 from the Department of Health, Education and Welfare. (1955)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 97 (1955), S. 461-491 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1000970306
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  • 8
    Electronic Resource
    Electronic Resource
    Light and electron microscopic observations on the cervical epithelium of the rabbit: II (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 185 (1989), S. 343-366 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The endocervical epithelium of long-term ovariectomized rabbits treated for 1-10 days with 5 μg of estradiol benzoate every 12 hr has been studied by light and electron microcopy. In addition, morphometric data on ciliated and nonciliated cells of rabbits treated for 2, 6, and 10 days are compared to those on untreated ovariectomized, estrous, and ovulatory rabbits.The percentage of ciliated cells increases after ovariectomy to 76.3% and that of secretory cells decreases to 23.7% as compared to estrous controls. Treatment of ovariectomized rabbits with estradiol results in a gradual increase in ciliated and secretory cell area, height, and nuclear area. After 10 days of treatment, cell areas are significantly larger than those in the ovulatory or estrous controls; cell height and nuclear areas have returned to preovariectomized levels; and the percentages of ciliated and secretory cells have reached those of estrous levels. Estradiol stimulates mitotic division of secretory cells but affects ciliogenesis minimally.In ciliated cells, estradiol treatment results in a modest increase in polysomes and granular endo-plasmic reticulum and in striking increases in the size of the Golgi complex and in the number of lipofuscin bodies as compared to those in the ovariectomized controls.In secretory cells, estradiol treatment brings about an increase in the numbers of polysomes, Golgi complexes, and cisternae of the granular en-doplasmic reticulum, in the sizes of the nucleoli, and in the amount of euchromatin. Secretory granules appear in some cells after 2 days of estradiol stimulation and increase in number through 10 days of treatment. Perinuclear granules are more pleomorphic and heterogeneous in structure and more numerous in the 6- to 10-day-estradiol-treated than in ovulatory animals, and they may function as lysosomes degrading excess secretory product. Deep apical concavities of the secretory cells occur most often after 2 and 6 days of treatment.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001850402
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  • 9
    Electronic Resource
    Electronic Resource
    The total number of spermatozoa reaching various segments of the reproductive tract in the female Albino rat at intervals after inseminationThis investigation was supported by a grant from the Committee for Research in Problems of Sex, National Research Council, and the Dr. Henry C. Buswell Memorial. (1949)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 103 (1949), S. 93-109 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091030107
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  • 10
    Electronic Resource
    Electronic Resource
    The fine structure of uterine smooth muscle of the rat uterus at various time intervals following a single injection of estrogenThis investigation was supported by USPHS grants AM-08029-04 and HD-00606. The authors are grateful to Dr. Norman Sulkin for making the electron microscope available. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 123 (1968), S. 369-383 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The fine structure of smooth muscle cells of the rat uterus was studied at 6, 12, 24, 48, 72 and 96 hours after a single subcutaneous injection of estradiol dipropionate (10 μg). The control rats were ovariectomized, but did not receive hormone treatment. Changes in the ultrastructure of the muscle cells occurred soon after estrogen stimulation. An increase in the number of ribosomes on the outer nuclear membrane and evagination of the membrane into the surrounding cytoplasm was noted at six hours. The amount and dilatation of the granular endoplasmic reticulum (GER) increased gradually from 6 to 96 hours. At 24 and 48 hours the mitochondria appeared to increase in number and at later time intervals they increased in size. The Golgi complex was more prominent at 72 and 96 hours than at the earlier time intervals. An increase in free ribosomes was observed at 6 and 12 hours, but a marked accumulation of them occurred at 24 hours and continued to 96 hours. The glycogen granules were very pronounced at 24 and 48 hours with a reduction at 72 and 96 hours. Many pinocytotic vesicles and dense bodies were present in the controls and at 6 and 12 hours. A decrease in number occurred in both at the later time intervals. Organelles accumulated at the nuclear poles beginning at 24 hours and extending to 96 hours. The observations made provide additional information on the fine structure of uterine smooth muscle cells following estrogen stimulation and support previous biochemical studies on glycogen concentration and RNA synthesis in the rat uterus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001230209
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