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  • 1
    Electronic Resource
    Electronic Resource
    Human motor-cortex oxygenation changes induced by cyclic coupled movements of hand and foot (1999)
    Springer
    Experimental brain research 129 (1999), S. 457-461 
    Details
    ISSN: 1432-1106
    Keywords: Key words Associated voluntary movements ; Motor cortex ; Man ; Near infrared spectroscopy ; Hemoglobin oxygenation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Near-infrared spectroscopy (NIRS) was used to assess human motor-cortex oxygenation changes in response to cyclic coupled movements of hand and foot. Using a highly sensitive NIRS instrument, we showed that it was possible to detect reproducible oxygenation patterns using single cycles (20 s) of easy and difficult association tasks. No significant differences in the time corresponding to the maximal changes in concentration of oxy- and deoxyhemoglobin ([O2Hb] and [HHb], respectively) were found during easy and difficult association as well as cycles. Only [O2Hb] showed a significantly higher value at the end of the difficult association during the first cycle. No significant differences were found for [O2Hb] and [HHb] in the other cycles. We conclude that NIRS is a useful addition to functional magnetic resonance imaging in investigating the time course of cortical activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050913
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: Combined near infrared spectrophotometry and Doppler ultrasound study (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 782-782 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954505
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: Combined near infrared spectrophotometry and Doppler ultrasound study (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 504-509 
    Details
    ISSN: 1432-1076
    Keywords: Indomethacin ; Patent ductus arteriosus ; Cerebral oxygenation ; Near infrared spectrophotometry ; Doppler ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objectives of this study were to evaluate the effect of repeated indomethacin administration on cerebral oxygenation in relation to changes in cerebral blood flow velocity (CBFV) and other relevant physiological variables. Fourteen preterm infants with patent ductus arteriosus were studied during three subsequent indomethacin bolus administrations with intervals of 12 and 24 h. Changes in concentration of oxyhaemoglobin (cO2Hb), deoxyhaemoglobin (cHHb) and oxidized cytochrome aa3 (cCyt.aa3) in cerebral tissue and changes in cerebral blood volume (CBV) were measured by near infrared spectrophotometry; changes in mean CBFV in the internal carotid artery were measured by pulsed Doppler ultrasound. Simultaneously heart rate, transcutaneouspO2 andpCO2, arterial O2 saturation and blood pressure were measured. All variables were continuously recorded until 60 min after indomethacin administration. Within 5 min after each indomethacin administration, significant decreases in CBFV, CBV and cO2Hb and cCyt.aa3 were observed which persisted for at least 60 min, while cHHb increased or did not change at all. There were no changes in the other variables recorded. These data demonstrate that indomethacin administration is accompanied by a reduction in cerebral tissue oxygenation due to decreased cerebral blood flow. Therefore, low arterial oxygen content, either caused by low arterial O2 saturation or by low haemoglobin concentration, may be a contraindication for indomethacin treatment in preterm infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957006
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: combined near infrared spectropho- tometry and Doppler ultrasound study (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 504-509 
    Details
    ISSN: 1432-1076
    Keywords: Key words     Indomethacin ; Patent ductus arteriosus ; Cerebral oxygenation ; Near infrared spectrophotometry ; Doppler ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      The objectives of this study were to evaluate the effect of repeated indomethacin administration on cerebral oxygenation in relation to changes in cerebral blood flow velocity (CBFV) and other relevant physiological variables. Fourteen preterm infants with patent ductus arteriosus were studied during three subsequent indomethacin bolus administrations with intervals of 12 and 24 h. Changes in concentration of oxyhaemoglobin (cO2Hb), deoxyhaemoglobin (cHHb) and oxidized cytochrome aa3 (cCyt.aa3) in cerebral tissue and changes in cerebral blood volume (CBV) were measured by near infrared spectrophotometry; changes in mean CBFV in the internal carotid artery were measured by pulsed Doppler ultrasound. Simultaneously heart rate, transcutaneous pO2 and pCO2, arterial O2 saturation and blood pressure were measured. All variables were continuously recorded until 60 min after indomethacin administration. Within 5 min after each indomethacin administration, significant decreases in CBFV, CBV and cO2Hb and cCyt.aa3 were observed which persisted for at least 60 min, while cHHb increased or did not change at all. There were no changes in the other variables recorded. These data demonstrate that indomethacin administration is accompanied by a reduction in cerebral tissue oxygenation due to decreased cerebral blood flow. Therefore, low arterial oxygen content, either caused by low arterial O2 saturation or by low haemoglobin concentration, may be a contraindication for indomethacin treatment in preterm infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957006
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of blood transfusion and haemodilution on cerebral oxygenation and haemodynamics in newborn infants investigated by near infrared spectrophotometry (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 305-310 
    Details
    ISSN: 1432-1076
    Keywords: Key words Doppler  ;  Cerebral blood flow  ;  Anaemia  ; Polycythaemia  ;  Haemoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to investigate the influence of blood transfusion and haemodilution on cerebral oxygenation and haemodynamics in relation to changes in cerebral blood flow velocity (CBFV) and other relevant physiological variables in newborn infants. Thirteen preterm infants with anaemia (haematocrit 〈 0.33) and ten infants with polycythaemia (haematocrit 〉 0.65) were studied during blood transfusion and haemodilution respectively using adult red blood cells and partial plasma exchange transfusion. Changes in cerebral concentrations of oxyhaemoglobin (cO2Hb), deoxyhaemoglobin (cHHb), total haemoglobin (ctHb), (oxidized - reduced) cytochrome aa3 (cCyt.- aa3) were continuously measured using near infrared spectrophotometry throughout the whole procedure. Simultaneously, changes of mean CBFV in the internal carotid artery were continuously measured using pulsed Doppler ultrasound. Heart rate, transcutaneous partial pressure of oxygen and carbon dioxide, and arterial O2 saturation were continuously and simultaneously measured. Blood transfusion resulted in increase of cO2Hb, cHHb, ctHb and red cell transport (product of CBFV and haematocrit), whereas CBFV decreased. The increase of cO2Hb exceeded that of cHHb, reflecting improvement of cerebral O2 supply. Haemodilution resulted in a decrease of cO2Hb, cHHb and ctHb, whereas CBFV increased. Red cell transport was unchanged. The decrease of cO2Hb exceeded that of cHHb, reflecting decreased cerebral O2 supply. cCyt.aa3 decreased after blood transfusion and remained unchanged after haemodilution, but the reliability of these results is uncertain. With the exception of a small, but significant increase in transcutaneous partial pressure of oxygen after blood transfusion, the other variables showed no changes. Each blood withdrawal during exchange transfusion resulted in only a significant increase in heart rate without changes in the other variables measured, suggesting unchanged cerebral perfusion. Conclusion In newborn infants blood transfusion in anaemia results in improvement of cerebral oxygenation, but haemodilution in polycythaemia does not improve cerebral oxygenation despite possible improvement of cerebral perfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050606
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  • 6
    Electronic Resource
    Electronic Resource
    Pulse oximetry in methaemoglobinaemia (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 45 (1990), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1990.tb14507.x
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  • 7
    Electronic Resource
    Electronic Resource
    SUBCUTANEOUS OXYGEN TENSION IN THE FETAL SCALP DURING LABOUR CONTINUOUS MONITORING WITH A NEEDLE ELECTRODE (1981)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Continuous intrapartum PO2 recordings were made in 25 fetuses, using a needle electrode that measures PO2 in the subcutaneous (sc) tissue of the scalp or the breech. This small electrode is combined with a spiral ECG electrode and can be easily applied in early labour. One hour after application of the electrode in the early first stage, a mean fetal scPO2 of 29.4±7.5 mm Hg was found. In the course of labour, scPO2 gradually fell to a mean value of 22.2±5.6 mm Hg, recorded just before the onset of bearing down contractions, and stabilised in the second stage of labour. ScPO2 values of less than 10 mm Hg were not recorded for a longer period except in one case of severe fetal distress. The relation between scPO2 just before delivery and cord arterial PO2 revealed a coefficient of correlation of 0.85. In general, scPO2 appeared higher than tcPO2 as described in the literature. This is ascribed to the different technique of measurement: the needle electrode measures in the deeper layers of the scalp, whereas the tc electrode is supplied with oxygen from the more superficial capillaries, where blood flow is more liable to be affected by mechanical factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1981.tb01026.x
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  • 8
    Electronic Resource
    Electronic Resource
    Experience with delayed repair of congenital diaphragmatic hernia during extracorporeal membrane oxygenation in a European center (1993)
    Springer
    Pediatric surgery international 8 (1993), S. 187-190 
    Details
    ISSN: 1437-9813
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In high-risk patients with congenital diaphragmatic hernia (CDH), we conducted a strategy of delayed repair following preoperative stabilization, including ECMO if necessary. From January 1991 to July 1992, preoperative ECMO treatment was delivered to 6 out of 14 high-risk patients with CDH. In this study, we report our experience with this policy of preoperative stabilization in six ECMO-treated patients in whom the diaphragmatic defect was repaired on ECMO. In all patients bleeding complications occurred. Three of the six ECMO-treated patients died, in two cases due to recurrent persistent pulmonary hypertension. Overall mortality was 43%. Conceptual aspects of our approach are discussed. Since the goals of our policy were not achieved, adjustments and renovations of the management protocol are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182514
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  • 9
    Electronic Resource
    Electronic Resource
    Direct Recording of Oxyhaemoglobin Dissociation Curve in vivo (1972)
    [s.l.] : Nature Publishing Group
    Nature 237 (1972), S. 149-150 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] An experimental technique for in vivo measurements of O2 dissociation curves is described. This allows rapid determination of Po2 and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/237149a0
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  • 10
    Electronic Resource
    Electronic Resource
    The oxygen binding capacity of human haemoglobin (1977)
    Springer
    Pflügers Archiv 369 (1977), S. 223-231 
    Details
    ISSN: 1432-2013
    Keywords: Oxygen binding capacity ; Hüfner's factor ; Haemoglobin ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The internationally standardized HiCN method for measuring the total haemoglobin concentration of the blood (c Hb * ) is based on the chemical composition of the haemoglobin molecule. If all haemoglobin measured in the blood by this method were active, i.e., capable of reversibly binding O2, the O2 binding capacity (β) would be 1.39 ml · g−1 The experimental values of β to be found in the literature vary over a wide range, values as low as 1.24 ml · g−1 being no exception. We determined β for 36 blood samples of healthy men, using for the determination of the O2 content 3 independent methods, i.e., a manometric, a polarographic and a chemical one. Before the measurements the blood was equilibrated with humidified pure O2 for 3 h. Appropriate corrections for dissolved O2 were made. The mean β was 1.368 ml · g−1, with a s.d. of 0.017 ml · g−1 (median 1.372 ml · g−1; range 1.322–1.387 ml · g−1). This mean β corresponds to 98.4% active haemoglobin. The inactive haemoglobin consisted of 0.7% HbCO, Hi and SHb (“dyshaemoglobin”) and 0.9% unidentified inactive haemoglobin. In 4 samples a high fraction of unidentified inactive haemoglobin was found (2.8–4.3%). Taking into account that in addition to this fraction a considerable amount of dyshaemoglobin (especially HbCO) may be present in the blood of normal men, it must be concluded that calculating the O2 carrying capacity of the blood by multiplyingc Hb * by a constant value of β, may be subject to an appreciable error. If β=1.39 ml · g−1 is used, the O2 carrying capacity of the blood may easily be found 10–15% too high.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582188
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