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  • 1
    Electronic Resource
    Electronic Resource
    A retrospective study on the efficacy of cervical lymph node dissection in well-differentiated carcinoma of the thyroid (1990)
    Springer
    Surgery today 20 (1990), S. 143-150 
    Details
    ISSN: 1436-2813
    Keywords: thyroid cancer ; neck dissection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The management of cervical lymph node metastases in well-differentiated carcinoma of the thyroid is controversial. In our department, from 1963 to 1972, node plucking was performed only in patients with cervical lymphadenopathy whereas, from 1973 to 1983, modified radical neck dissection was therapeutically or electively performed. In order to determine whether the more extensive dissection is adequate, a retrospective analysis was performed using two groups of patients who were managed differently with regard to the treatment of cervical lymph node metastases. From this series of 206 patients with more than five years follow-up, it was found that the rates of survival and lymph node recurrence did not differ between the two groups. However, since the well-differentiated carcinoma of the thyroid has relatively indolent biological behaviour, further long-term follow-up seems to be necessary for demonstrating the efficacy of neck dissection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470761
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  • 2
    Electronic Resource
    Electronic Resource
    A multivariate study of the relationship between regional lymph node metastases and prognosis in patients with operable breast cancer (1991)
    Springer
    Surgery today 21 (1991), S. 613-620 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; lymph node metastases ; prognostic variables
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to evaluate the prognostic importance of clinical and histological node information, we made univariate and multivariate analyses of regional lymph node metastases in 223 patients with operable breast cancer who were surgically treated from 1973 to 1985. Clinical axillary node status, histological involvement of the axillary lymph nodes, their anatomical levels and numbers, and histological involvement of the internal mammary lymph nodes were selected as evaluating prognostic factors. The histological presence or absence of axillary node involvement, especially at the distal level, proved to be the most important prognostic factor. However, neither the anatomical level nor the number of histologically involved axillary lymph nodes appeared to be an important prognostic factor. On the other hand, histological involvement of the internal mammary nodes appeared to be an important and independent prognostic factor. Therefore, we concluded that axillary lymph node dissection with a biopsy of the internal mammary nodes would provide more accurate information about the prognosis of patients with operable breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471045
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The psychological and cosmetic aspects of breast conserving therapy compared with radical mastectomy (1993)
    Springer
    Surgery today 23 (1993), S. 598-602 
    Details
    ISSN: 1436-2813
    Keywords: psychological morbidity ; cosmetic ; breast conserving therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An evaluation of the psychological and cosmetic morbidity of 31 patients who had undergone breast conserving treatment (BCT group) and 71 patients who had undergone radical mastectomy (RM group) revealed that 85% and 73%, respectively, were satisfied with their operative results. BCT appeared superior to RM in relation to body image, with 93% of the BCT group indicating BCT as a future choice of treatment, whereas only 35% of the RM group indicated RM as a future choice of treatment. For 59% of the BCT patients, the results were considered excellent or good by a physician, but fear of recurrence was frequently expressed by both groups even though an early stage of breast cancer had been significantly more common in the BCT group than the RM group. Sexual adjustment was the same in both groups. Body image was thus concluded to have been improved by BCT rather than RM, but psychological morbidity was essentially the same in both groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311907
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  • 4
    Electronic Resource
    Electronic Resource
    A retrospective study on the clinical and biological prediction of axillary lymph node metastasis in breast cancer (1993)
    Springer
    Surgery today 23 (1993), S. 573-579 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; axillary lymph node metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract If axillary lymph node metastases were able to be accurately predicted, dissection could be avoided in some patients with breast cancer whose axillary nodes are clinically negative. In this study, we assessed the relationships between histological axillary lymph node metastases and clinical axillary nodal status, tumor size, DNA-ploidy, c-erbB-2 expression, and the score of the argyrophilic nucleolar organizer region. We then attempted to evaluate their predictive values for axillary lymph node metastasis in 173 patients with invasive breast cancer, retrospectively. The clinical and biological variables were significantly correlated with the presence and degree of axillary lymph node metastases. A metastatic index, calculated from the clinical and biological variables, proved especially useful for predicting axillary lymph node metastases in patients whose axillary nodes were clinically negative. However, the predictive abilities were still limited and thus it was concluded that as yet, only axillary dissection can provide accurate information on axillary lymph node metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311903
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  • 5
    Electronic Resource
    Electronic Resource
    The relationship between lymph node metastases and DNA-ploidy status as prognostic factors in invasive breast cancer (1992)
    Springer
    Surgery today 22 (1992), S. 213-220 
    Details
    ISSN: 1436-2813
    Keywords: prognostic factor ; lymph node metastases ; DNA-ploidy status ; breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the relationship between the regional lymph node metastases and the DNA ploidy status in 207 patients with invasive breast cancer, as well as their prognostic values in estimating the prognosis of breast cancer. A significantly higher incidence of aneuploidy was found in patients with a large T3 or T4 tumor, a positive axillary lymph node status, more than 4 positive axillary lymph nodes or positive internal mammary lymph nodes. In a univariate study, the overall survival was significantly correlated with tumor size, axillary lymph node status, axillary and internal mammary lymph node metastases, and DNA ploidy status. In the multivariate analysis, however, only axillary and internal mammary lymph node metastases were recognized as important independent prognostic factors on survival. In this series, the DNA ploidy status did not appear to be an independent prognostic factor either in the entire series or in negative axillary node patients, since it was closely correlated with the axillary or internal mammary lymph node metastases, and the axillary node negative patients had an extremely favorable prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308825
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A comparison of breast cancers detected by mass screening and those found in out-patient clinics (1993)
    Springer
    Surgery today 23 (1993), S. 325-330 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; mass screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the results of a mass screening study on breast cancer detection by physical examination alone conducted in Ishikawa Prefecture from 1978 to 1990. The number of cases of breast cancer detected by mass screening was then compared with that found in out-patient clinics during the same period. Breast cancer was detected in 88 of 152,969 women by mass screening, the detection rate being 0.06% for the total study: 0.08% at the initial screening and 0.04% at periodic screenings. Early stage breast cancer was more frequently detected during periodic screenings than at the initial screening or in out-patient clinics. Moreover, although the initial screenings may have identified patients with breast cancer at more advanced stages, the survival was not significantly different. The results of this series led us to conclude that mass screening by physical examination alone may have no impact on the mortality rate of breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309050
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  • 7
    Electronic Resource
    Electronic Resource
    Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): Report of a case (1995)
    Springer
    Surgery today 25 (1995), S. 158-160 
    Details
    ISSN: 1436-2813
    Keywords: anaplastic thyroid carcinoma ; G-CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the unusual case of a 60-year-old woman with an anaplastic thyroid carcinoma which produced granulocyte colony stimulating factor (G-CSF). She presented with large neck masses, respiratory difficulty, and a high fever. Laboratory examinations revealed marked leukocytosis of 43,200/mm3 with 85% granulocytes and an elevated G-CSF level of 67 pg/dl. Total thyroidectomy with bilateral node dissection and tracheostomy was performed, and a histological diagnosis of large-cell anaplastic thyroid carcinoma was confirmed. Immunohistochemical examination with a polyclonal antibody against G-CSF stained the tumor cells. Although the respiratory difficulty, fever, and marked granulocytosis subsequently improved, she died 1 month after undergoing surgery due to metastatic mediastinal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311090
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  • 8
    Electronic Resource
    Electronic Resource
    Lymph node metastases versus DNA ploidy as prognostic factors for invasive ductal carcinoma of the breast (1991)
    Springer
    Breast cancer research and treatment 19 (1991), S. 23-31 
    Details
    ISSN: 1573-7217
    Keywords: prognostic factor ; lymph node metastases ; DNA ploidy ; breast cancer ; internal mammary nodal status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the relationship between the DNA ploidy status and other variable prognostic factors, especially regional lymph node metastases, in 121 patients with invasive ductal carcinoma of breast, together with the value of these factors in estimating the prognosis of breast cancer. The ploidy status was diploid in 40% of the patients, and aneuploid in 60%. A significantly higher incidence of aneuploidy was found in patients with more than 4 positive axillary lymph nodes, positive internal mammary lymph nodes, or clinical stage 3 of malignancy. In a univariate study, overall survival and disease-free survival were significantly correlated with axillary and internal mammary lymph node metastases, tumor size, and clinical stage of malignancy. The disease-free survival rates for the diploid group tended to be somewhat higher than those for the aneuploid group of patients without axillary lymph node metastases. In the multivariate analysis, however, only axillary lymph node metastasis was significantly correlated with overall survival and disease-free survival. There was also a trend for the internal mammary lymph node metastases to be correlated with survival. As the DNA ploidy status was closely correlated with the axillary and internal mammary lymph node metastases, it did not appear to be an independent prognostic factor in this small series.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975201
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    Paper (German National Licenses)
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