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  • 1
    Electronic Resource
    Electronic Resource
    [13C]methacetin breath test for evaluation of liver damage (1987)
    Springer
    Digestive diseases and sciences 32 (1987), S. 344-348 
    Details
    ISSN: 1573-2568
    Keywords: 13C-methacetin breath test ; 13C-aminopyrine breath test ; chronic liver disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methacetin undergoes rapid O-dealkylation by hepatic microsomal enzyme systems, and the resultant CO2 is present in the expired air. The rate of O-dealkylation of methacetin was assessed by the [13C]methacetin breath test in seven healthy volunteers and 30 patients with histologically proven chronic liver diseases. The 30-min recovery of orally administered [13C]methacetin as13CO2 in the exhaled air was significantly reduced in patients with chronic aggressive hepatitis and in those with liver cirrhosis but not in patients with chronic persistent hepatitis or healthy controls. Patients with either advanced cirrhosis or hepatocellular carcinoma showed significantly lower values than those with well-compensated cirrhosis. The levels in two patients with late primary biliary cirrhosis were reduced. These results show that the severity of liver damage can be effectively evaluated by [13C]methacetin breath test. In addition, this test is simple, safe, and time efficient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296285
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Growth regulation of rabbit gastric epithelial cells and protooncogene expression (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 1454-1463 
    Details
    ISSN: 1573-2568
    Keywords: gastric mucosa ; primary culture ; growth factor ; c-fos ; c-myc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We recently developed a primary culture system for gastric epithelial cells from adult rabbits that allows the investigation of growth regulation at the cellular level. In this study, we demonstrated that epidermal growth factor (EGF), insulin, and dibutyryl adenosine 3′,5′-cyclic monophosphate (dBcAMP) all stimulated cell proliferation. Insulin and dB-cAMP potentiated the stimulation of cell proliferation by EGF, while transforming growth factor-β1 (TGF-β1) inhibited it. Expression of c-fos and c-myc was induced in response to the stimulation by these growth regulators, but the degree of expression did not necessarily correlate with the effects of these agents on cell proliferation. In conclusion, EGF, insulin, and dBcAMP were positive growth regulators, while TGF-β1 was a negative regulator in gastric epithelial cells. These growth modulators may exert their effects by distinct pathways from a standpoint of the expression of c-fos and c-myc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088048
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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