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  • 1
    Digitale Medien
    Digitale Medien
    Silicone Gel-Filled Breast Implants: Is Local Inflammation Associated With Fat Necrosis? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    The @breast journal 1 (1995), S. 0 
    Details
    ISSN: 1524-4741
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Granuloma formation and chronic inflammation are local reactions that are associated with implantation of medical grade silicone. These responses lead to capsular contraction, pain, and cosmetic problems. In addition, there have been a few reports of connective tissue disease in patients with silicone gel-filled implants. The purpose of this paper is to raise the possibility that local responses to silicone gel-filled implants are mediated by fat necrosis.Results of histologic findings and patient records in six patients indicate that patients experiencing implant leakage or failure exhibited classic signs of a foreign-body response, including the presence of giant cells and foamy macrophages. Most of the observed vacuoles were empty and appeared similar to enucleated fat cells, although some contained foreign material. These observations suggest that the physical presence or degradation products of the implants may have elicited fat cell necrosis that contributed to the chronic inflammatory response. In contrast, patients with intact implants showed no signs of a chronic foreign-body response. None of the patients in this study demonstrated any systemic complications.It is concluded that although there have been numerous reports of empty vacuoles containing silicone that are either derived from the membrane that surrounds the implant or from the gel, there are no reports linking these vacuoles to the vacuoles seen in fat tissue necrosis, even though histologically the two processes are morphologically similar. Therefore, it is important to ask whether some of the adverse reactions observed with silicone gel-filled implants may be mediated via fat cell necrosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1524-4741.1995.tb00214.x
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  • 2
    Digitale Medien
    Digitale Medien
    LETTER TO THE EDITOR (2000)
    Boston, MA, USA : Blackwell Science Inc
    The @breast journal 6 (2000), S. 0 
    Details
    ISSN: 1524-4741
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1524-4741.2000.99077.x
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  • 3
    Digitale Medien
    Digitale Medien
    Wound healing using a collagen matrix: Effect of DC electrical stimulation (1988)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 22 (1988), S. 191-206 
    Details
    ISSN: 0021-9304
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin , Technik allgemein
    Notizen: Rapid fibroblast ingrowth and collagen deposition occurs in a reconstituted type I collagen matrix that is implanted on fullthickness excised animal dermal wounds. The purpose of this study is to evaluate the effects of direct current stimulation on dermal fibroblast ingrowth using carbon fiber electrodes incorporated into a collagen sponge matrix. Preliminary results suggest that fibroblast ingrowth and collagen fiber alignment are increased in collagen sponges stimulated with direct currents between 20 and 100 μA. Maximum fibroblast ingrowth into the collagen sponge is observed near the cathode at a current of 100 μA. These results suggest that electrical stimulation combined with a collagen matrix may be a method to enhance the healing of chronic dermal wounds.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jbm.820221310
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