Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
20 (1973), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract— Purified unique sequences of human DNA (from HeLa cells) were hybridized with various preparations of human brain KNA, to obtain estimates of the fraction of DNA transcribed. Values of 12 per cent were obtained for fetal brain increasing to 24 per cent for specific regions of adult brain. Right and left parietal and temporal cortical RNA gave similar plateau values but left frontal cortical RNA appeared to represent 2–3 times as much of the total genome as that from right frontal cortex. Lower values were obtained for fetal and adult brain stem and for RNA prepared from temporal cortex of a patient exhibiting gross cerebral atrophy. Attempts were made to assess the contributions of glial and neuronal cells by using human astrocytoma and mouse neuroblastoma RNA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1973.tb00077.x
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