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  • 1
    Electronic Resource
    Electronic Resource
    One stage revision arthroplasty of the hip for deep gram negative infection (1996)
    Springer
    International orthopaedics 20 (1996), S. 12-14 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Nous présentons une série de quinze révisions en un temps pour arthroplasties de la hanche infectées par germes Gram négatifs. Le suivi moyen a été de huit ans. Dans quatorze cas, nous n’avons pas constaté de récidive septique. Dans le cas ayant présenté une récidive d’infection, du ciment sans antibiotique avait été utilisé lors de la révision. Une infection à germes Gram négatif ne doit pas être considérée comme une contre-indication à une révision d’arthroplastie de hanche en un temps, pour autant que la prothèse soit réimplantée avec du ciment chargé en antibiotique.
    Notes: Summary. We describe the use of one stage revision arthroplasty of the hip for deep gram negative infections. We have followed up 15 patients for an average of 8 years following operation. Two procedures failed, one at two years due to aseptic loosening and another because of persistent infection. We attribute the low reinfection rate (1/15) to meticulous surgical technique, preoperative parenteral antibiotics and antibiotic loaded cement. Both failures occurred in the two operations performed without antibiotic loaded cement. We do not recommend the use of plain cement for exchange hip arthroplasty in the presence of gram negative infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050019
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  • 2
    Electronic Resource
    Electronic Resource
    Inclusion formation in Huntington's disease R6/2 mouse muscle cultures (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 87 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion in the number of glutamine repeats in the N-terminal region of the huntingtin protein. Nuclear and cytoplasmic aggregates of the N-terminal portion of huntingtin have been found in the brains of HD patients and the brains and non-neuronal tissues of the R6/2 HD transgenic mouse. We have cultured myoblasts and myotubes from transgenic R6/2 mice and littermate controls to investigate the formation of these inclusions in post mitotic cells. Huntingtin immunoreactivity was intense in differentiating, desmin positive myoblasts and myotubes from both control and R6/2 mice suggesting that it may play a role in myotube differentiation. Following differentiation huntingtin and ubiquitin positive aggregates were observed in R6/2 but not control cultures. After 3 weeks in differentiation medium cytoplasmic huntingtin and ubiquitin immunoreactive aggregates were observed in non-myotube cells, while nuclear huntingtin aggregates were seen in a proportion of myotubes after 6 weeks. Growth in the absence of serum resulted in a marked increase in the number of R6/2 myotubes containing nuclear inclusions after 6 weeks demonstrating that environmental factors influenced huntingtin aggregate formation in these cells. Consequently, cultured myotubes from R6/2 mice may be a useful post mitotic cell culture model to study both the biochemical consequences of huntingtin aggregates and the factors that may influence aggregate formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.02009.x
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  • 3
    Electronic Resource
    Electronic Resource
    ALS-IgG-induced selective motor neurone apoptosis in rat mixed primary spinal cord cultures (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 94 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is evidence that in sporadic amyotrophic lateral sclerosis (ALS) immunological mechanisms may be involved in the pathophysiology of the disease. We tested whether purified IgG from ALS patients induce cell death in rat mixed primary spinal cord cultures and compared this with the effect of IgG purified from patients with Guillain–Barré syndrome (GBS) or from healthy donors. Treatment with ALS-IgG increases caspase-3 apoptosis when compared with control IgG or with GBS-IgG, but does not induce death by necrosis. Because ALS is characterized by the selective loss of motor neurones, we next assessed the differential effect of ALS-IgG on motor neurones or astrocytes. We showed, semiquantitatively, that motor neurones are more susceptible to apoptosis when cultures were treated with ALS-IgG compared with control-IgG. In conclusion, we have demonstrated in primary spinal cord cultures that IgG from patients with ALS induces apoptosis selectively in motor neurones, and that the caspase-3 pathway is involved. This suggests that immunological mechanisms may contribute to the selective loss of motor neurones in ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03184.x
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  • 4
    Electronic Resource
    Electronic Resource
    Doxycycline Inhibition of Cartilage Matrix Degradation (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 732 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb24770.x
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  • 5
    Electronic Resource
    Electronic Resource
    Chronisches Cor pulmonale Epidemiologie, Pathophysiologie und Klinik (1999)
    Springer
    Der Internist 40 (1999), S. 722-728 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Cor pulmonale ; Pathophysiologie ; Hypoxämie ; Cor pulmonale ; Epidemiologie ; Remodelling ; Pulmonalgefäße
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Dem Cor pulmonale mit den typischen klinischen Symptomen Dyspnoe, Müdigkeit, Herzrhythmusstörungen, retrosternalen Schmerzen, Oberbauchbeschwerden durch Leberschwellung, vermehrter Jugularvenenfüllung, Beinödemen und Zyanose liegen verschiedene pulmonale Krankheitsbilder mit meist jahrelangem chronischen Verlauf zugrunde. Im Rahmen dieser Übersicht wird deren Pathogenese eingehend erläutert, nachdem zunächst die Physiologie der pulmonalen Zirkulation erörtert wird. Die epidemiologischen Zahlen unterstreichen die Bedeutung des Krankheitsbildes Cor pulmonale, das bei 5–10% aller Herzkrankheiten und 10–30% aller stationär mit Herzinsuffizienz behandelten Patienten vorliegt. In fast der Hälfte aller Fälle mit chronisch obstruktiver Atemwegserkrankung (COPD) findet sich ein Cor pulmonale. Komplementär zu dieser Übersicht sind andere Arbeiten dieses Hefts, besonders aber die von Ch. Perings et al. zur Diagnostik und D. Köhler zur Therapie des Cor pulmonale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050393
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  • 6
    Electronic Resource
    Electronic Resource
    Analyse der Asche von Bromus-Arten (1853)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 60 (1853), S. 442-443 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.18530600183
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  • 7
    Electronic Resource
    Electronic Resource
    Ueber die Chinesischen Gelbschoten (1855)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 64 (1855), S. 10-15 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.18550640102
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