ISSN:
1573-4986
Keywords:
oligoethylene spacer
;
oligosaccharide conjugation
;
glycoconjugate
;
protein coupling
;
N,N,N′,N″-tetramethyl(succinimido)uronium tetrafluoroborate (TSTU)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Glycosides of glucose and lactose with di- and tetraethylene glycols, transformed into bifunctional (alcohol, ester) spacer molecules, have been synthesized. After deprotection, these spacer glycosides, containing a free carboxyl group, have been transformed efficiently into glycoconjugates usingN,N,N′,N″-tetramethyl(succinimido)uronium tetrafluoroborate (TSTU) for the formation of an active ester.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00702200
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