ISSN:
1432-1041
Keywords:
Key words Algorithm
;
Drug surveillance; adverse drug reactions
;
epidemiologic methods
;
case-control studies
;
cohort studies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Spontaneous reporting of adverse drug reactions (ADRs), although commonly used, is of limited efficacy for the establishment of causation, and must be complemented by more rigorous epidemiologic studies. This article presents a decision algorithm that could be used as a tool in the selection of the most appropriate study design to investigate the causal relationship between a given ADR and a drug. It is based on the incidence of the ADR, on the objective of the study – determination of all the adverse effects of a given drug, or all the drugs increasing the risk of occurrence of a given adverse event – and on the funds available to the researcher.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050228
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