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  • 1
    Electronic Resource
    Electronic Resource
    Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 693-695 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On the other hand, ingestion of pure carbohydrate (CHO) diets8"10, and injection of Trp5 and drugs that affect 5-HT metabolism11 increase both total plasma and brain Trp. This led to the hypothesis that levels of total plasma Trp reflect levels of brain Trp8. The hypothesis has been challenged by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248693a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EVIDENCE THAT METHADONE BLOCKS DOPAMINE RECEPTORS IN THE BRAIN (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— This study has shown that methadone shares with phenothiazine and butyro-phenoneneuroleptics several pharmacological and biochemical actions:thus, D,L-methadone causes catalepsy and hypothermia, blocks apomorphine-induced gnawing, increases brain homovanillic acid levels and stimulates brain dopamine synthesis. The dextro isomer of methadone is inactive. α-Methyl-tyrosine potentiates and apomorphine reverses methadone-induced catalepsy. The data suggest that methadone, like butyrophenone and phenothiazine neuroleptics, blocks dopamine receptors in brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb01484.x
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  • 3
    Electronic Resource
    Electronic Resource
    STIMULATION OF BRAIN SEROTONIN SYNTHESIS BY DIBUTYRYL-CYCLIC AMP IN RATS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cyclic AMP and dibutyryl-cyclic AMP, a derivative of cyclic AMP resistant to phosphodiesterase inactivation, were injected into the lateral ventricles of rats. These nucleotides did not change the level of brain 5-HT but increased the brain level of its principal metabolite, 5-hydroxyindoleacetic acid. Cyclic AMP was less potent than dibutyryl-cyclic AMP. Butyrate and 5′-AMP were inactive. The effect of dibutyryl cyclic AMP on 5-HT metabolism was studied both in vivo and in vitro. The rate of synthesis of 5-HT was measured by the rate of accumulation of 5-hydroxyindoleacetic acid after the transport of this acid out of the brain was blocked with probenecid. The rate of synthesis of brain 5-HT increased from 0-38 μg/g/h in control rats to 0-65 μg/g/h after dibutyryl-cyclic AMP. In addition cyclic AMP and dibutyryl-cyclic AMP markedly increased brain tryptophan, while AMP was inactive. Since brain tryptophan hydroxylase has a Km for its substrate that is much higher than the concentrations of tryptophan normally present in the brain, it is likely that the increase in the rate of synthesis of brain 5-HT is secondary to the cyclic AMP induced increase in the levels of brain tryptophan. In vitro studies revealed that dibutyryl-cyclic AMP increased the uptake of radioactive labelled tryptophan into slices of rat brain stem and the formation of 5-HT and 5-hydroxyindoleacetic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb00218.x
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  • 4
    Electronic Resource
    Electronic Resource
    Prosopagnosia
    Amsterdam : Elsevier
    Neuropsychologia 2 (1964), S. 237-246 
    Details
    ISSN: 0028-3932
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0028-3932(64)90008-9
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  • 5
    Electronic Resource
    Electronic Resource
    Thymus gland involution induced by lithium chloride (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 646-648 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chronic treatment with lithium chloride produced significant involution of the thymus gland with histological evidence of reduced cellularity due to loss of thymic lymphocytes and a significant reduction in the weight of the gland in normal and adrenalectomized mice. Lithium also increased corticosterone levels in normal mice without changes in adrenal weights. The involution of the thymus gland is most likely due to an effect of lithium on the gland, and it is not mediated by adrenocortical mechanisms or stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946552
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  • 6
    Electronic Resource
    Electronic Resource
    Accelerated synthesis of dopamine in the rat brain after methadone (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 926-926 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto Nei ratti, ild, l-metadone fa aumentare significativamente i livelli di acido omovanillico e stimola il turnover della dopamina nei gangli della base. Il destro isomero è inattivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01924950
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