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  • 1
    Electronic Resource
    Electronic Resource
    Spontaneous spinal epidural haematomas (1991)
    Springer
    Acta neurochirurgica 111 (1991), S. 40-42 
    Details
    ISSN: 0942-0940
    Keywords: Spontaneous ; spinal epidural haematoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spontaneous spinal epidural haematoma (SSEH) is a rarity, but the severe and permanent motor disability underlines its importance. From 1957 seven cases of SSEH have been diagnosed and operated on in the National Institute of Neurosurgery, Budapest. These cases are analysed and discussed. The clinical picture began with local pain of the spine and radicular signs but some hours or days later paraparesis or paraplegia and incontinence developed. In the discussed cases the neurological deficit progressed to complete para- or tetraplegia in 5 cases. Only 2 patients had partial spinal transverse lesions on admission. All patients underwent myelography to detect the spinal space occupying lesion and were operated on soon. Three patients recovered completely, 2 remained partly and 2 totally paralysed. The outcome depended mainly on the timing of neurological deficiency. If the neurological signs existed less than 8 hours the patients recovered completely or fairly well while the prognosis was poor if the transverse lesion persisted longer than 24 hours. The authors stress the importance of correct and fast decisions at the first medical examination for the outcome of this disease, because only immediate transfer to a neurosurgical department gives a chance of good recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402511
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  • 2
    Electronic Resource
    Electronic Resource
    Pathological and experimental investigations in a case of gigantism (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 167-174 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary adenoma ; Gigantism ; Electron microscopy ; Immunocytochemistry ; Cell culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A pituitary adenoma was transsphenoidally removed from a 4.5-year-old girl suffering from gigantism. Prior to the operation both the growth hormone (GH) and the prolactin (PRL) levels in the serum were elevated. By light microscopy the tumor appeared to be an acidophilic adenoma. Two distinct cell types, the densely granulated and the sparsely granulated cells, could be distinguished by electron microscopy. Double immunolabeling revealed the presence of GH alone in some densely granulated cells and PRL alone in some sparsely granulated cells, as well as GH and PRL co-localized in both of the morphologically distinguished cell types. Both cell types were identified in the monolayer and the suspension cultures by electron microscopy. GH and PRL concentrations in the culture media were measured by radioimmunoassay. The basal secretion of growth hormone was almost uniform during the 3-week cell culture period. GH and PRL release was significantly inhibited by bromocriptine. Our studies revealed a bimorphous and bihormonal mixed adenoma in childhood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227764
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  • 3
    Electronic Resource
    Electronic Resource
    Growth characteristics of human pituitary adenomas in tissue and cell cultures (1980)
    Springer
    Acta neuropathologica 49 (1980), S. 225-230 
    Details
    ISSN: 1432-0533
    Keywords: Human pituitary adenomas ; Tissue culture ; Cell culture ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pituitary adenomas of 120 patients were investigated in tissue and in cell cultures. Under different conditions of culture, the biopsies revealed different rates of growth. In tissue cultures 66% of the samples could be propagated while tumour specimens explanted in cell suspensions proliferated in 80% of the cases. Attempts to establish subcultures were also more successful when specimens were put into cell cultures primarily. Further differences of growth characteristics were observed in connection with the histological types of the parent tissues. According to the old terminology cells of mixed type adenomas had the longest life-span both in tissue and in cell cultures. Considering the proliferative activity, this type of tumour could be most frequently subcultured. Concerning the relationship of different cell components of the biopsies it was proven that survival and proliferation of adenoma cells may occur without fibroblasts. The appearance of fibroblast-like cells in older cultures is a morphological manifestation of the senescence of the specific cell types. Qualitative features of cultured adenoma cells showed that on the basis of cytomorphological properties “chromophobe” samples could be separated from the other types. Cells of acidophil and mixed type growths had the capacity of developing in vitro various migratory shapes, while “chromophobe” cells did not possess this ability. The histological diagnoses made independently from cultures confirmed the tissue culture findings. Differences of in vitro characteristics correlated also with the ultrastructural features of the cultured adenoma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00707110
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  • 4
    Electronic Resource
    Electronic Resource
    Light- and electron-microscopic features of an endocrinologically active pituitary adenoma cultured in vitro (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 245-249 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary adenoma ; Cell culture ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A pituitary adenoma from an acromegalic female patient has been studied in cell cultures. Two populations of parenchymal cells, i.e., elongated shapes and big pale forms with irregular outlines, were distinguished light-microscopically. Ultrastructurally, three types of cells were found. Two of them contained secretory granules in varying numbers and sizes. Based on the proportion of the various cellular elements these cells were considered as counterparts of the elongated shapes being responsible for the GH secretion at different rates. The third cell type with very few secretory granules was identified with the big pale forms. Presumably, they could be exhausted GH-secreting cells. Besides fine structural characterisation, cultured cells of endocrinologically active human pituitary adenomas offer suitable models for studying some phases of exocytosis and membrane retrieval.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691254
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  • 5
    Electronic Resource
    Electronic Resource
    Intrasellar hamartoma associated with pituitary adenoma (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 328-333 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary adenoma ; Neuronal and lipomatous hamartoma ; Immunocytochemistry ; Electron micrscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histological, ultrastructural and immunocytochemical features are reported of an intrasellar neuronal and lipomatous hamartoma associated with pituitary growth hormone (GH) cell adenoma and acromegaly. Electron microscopy demonstrated a close contact between neurons and adenomatous GH cells. By immunohistochemistry the adenoma cells revealed a positive staining for GH and prolactin. the neurons of hamartoma showed neurosecretory activity which might have induced the development of pituitary GH cell adenoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294652
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  • 6
    Electronic Resource
    Electronic Resource
    Abscess formation in Rathke's cleft cyst (1992)
    Springer
    Acta neurochirurgica 117 (1992), S. 70-72 
    Details
    ISSN: 0942-0940
    Keywords: Rathke's cleft cyst ; pituitary ; abscess
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two patients are discussed who presented at our Institute with endocrine dysfunction and sellar enlargement. CT scans revealed intra and suprasellar expanding lesions with ring enhancement. The postoperative histological examination showed remnants of Rathke's cleft cyst together with signs of inflammation. CT and MRI pictures, and possible mechanisms of abscess formation in this region are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400640
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  • 7
    Electronic Resource
    Electronic Resource
    Pathological characteristics of surgically removed craniopharyngiomas: Analysis of 131 cases (1993)
    Springer
    Acta neurochirurgica 124 (1993), S. 139-143 
    Details
    ISSN: 0942-0940
    Keywords: Craniopharyngioma ; histopathology ; survival ; recurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pathological specimens of 131 surgically removed craniopharyngiomas were obtained from the registry of the National Institute of Neurosurgery. Budapest between 1977 and 1991. The cases were reviewed statistically with reference to their gross and microscopic features and clinical characteristics, Macroscopically, 34% of the tumours were cystic, 23% solid and 43% mixed. Histologically, 38% of the cases belonged to the adamantinous group, 26% were squamous epithelial type, 15% were combined, that is expressing the characteristics of both. In 21% of the cases the surgically removed samples did not contain enough material for correct histopathological classification. There was no recurrence in the group with the squamous epithelial type tumours, while 59% of the adamantinous, and 36% of the combined Craniopharyngiomas recurred. The 5-year survival proportion was 73% at the squamous epithelial, 60% in the adamantinous. and 55% at the combined histological types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401137
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  • 8
    Electronic Resource
    Electronic Resource
    Parallels between three-dimensional thinking in neurosurgery and the development of perspective in art (1993)
    Springer
    Acta neurochirurgica 124 (1993), S. 176-178 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401145
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  • 9
    Electronic Resource
    Electronic Resource
    European Association of Neurosurgical Societies Third European lecture Naples, 23 April, 1982 Some aspects of personality of the neurosurgeon (1982)
    Springer
    Acta neurochirurgica 65 (1982), S. 141-152 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405840
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  • 10
    Electronic Resource
    Electronic Resource
    Posterior fossa revascularization by superficial temporal artery (STA) — Superior cerebellar artery (SCA) anastomosis (1982)
    Springer
    Acta neurochirurgica 66 (1982), S. 43-53 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral revascularization ; microsurgery ; vertebrobasilar insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report a case with severe basilar artery flow disturbance and circle of Willis inadequacy causing mild brain stem stroke and vertebrobasilar transient attacks. An STA-SCA microarterial anastomosis was performed with success. The indication for this type of extracranial-intracranial (EC/IC) bypass is limited to those patients who have mild vertebrobasilar clinical symptomatology and whose angiographic studies reveal stenosis or occlusion of vertebral or basilar arteries distal to the origin of the posterior inferior cerebellar artery, and an inadequate circle of Willis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809302
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