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  • 1
    Electronic Resource
    Electronic Resource
    High dose Nutrizym 22 in cystic fibrosis (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 763-764 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract New high dose pancreatic enzyme preparations could be potentially helpful to cystic fibrosis (CF) patients. The purpose of this study was to compare the efficacy of the new high dose pancreatic enzyme preparation, Nutrizym 22 with the standard preparation Nutrizym GR. Twenty-five CF children (aged 7–16 years) entered the study and 22 completed it; 3 did not, due to non-compliance. All were taking Nutrizym GR for at least 2 weeks before entering the study. A randomised double blind, crossover method using standard Nutrizym GR or double strength Nutrizym 22 capsules was carried out over two consecutive 14-day periods. Crossover analyses of variance showed no statistically significant differences in actual weight gain, appetite, abdominal pain, stool consistency or faecal fat during the prestudy and study periods. It is concluded that half the capsule numbers of the high strength preparation are just as effective as the standard capsule dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953997
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Endometrial, physical and psychological effects of postmenopausal oestrogen therapy with added dydrogesterone (1990)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 97 (1990), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Sixteen postmenopausal women receiving conjugated equine oestrogens 1.25 mg/day. continuously, were randomly allocated to add dydrogesterone 20 mg/day for 12 days each calendar month for 3 months and then 10 mg/day in an identical fashion for a further 3 months, or to receive the dydrogesterone doses in reverse sequence. The effects of the two dydrogesterone doses on endometrial histology, vaginal bleeding, and the symptomatic and psychological status were compared. Endometrial samples were obtained around day 10 of progestogen addition. Dydrogesterone, 20 mg, induced uniform, late secretory transformation in all samples; with 10 mg one sample showed mixed early and late secretory features and another demonstrated late secretory changes associated with atypical hyperplasia. Both dydrogesterone doses induced an acceptable withdrawal bleed; most bleeding episodes were ‘spotting’ or normal in amount, and heavy bleeding was reported infrequently. There was one episode of breakthrough bleeding. There were no differences in bleeding patterns between the two dose regimens. Anxiety, and the physical and psychological status were significantly improved after 3 months of therapy. Significant benefits on depression were observed less clearly. There were no differences between the two dydrogesterone doses on anxiety, depression and the physical and psychological status, and, overall, the addition of the progestogen did not antagonize oestrogen benefits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1990.tb02497.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect on plasma lipids and lipoproteins of postmenopausal oestrogen therapy with added dydrogesterone (1990)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 97 (1990), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. In a prospective, randomized, cross-over study, 14 postmenopausal women completed 9 months of treatment with conjugated equine oestrogens, 1.25 mg daily. Seven women added dydrogesterone 20 mg daily for 12 days during months 2, 3 and 4, and then 10 mg daily for an identical time in months 5,6 and 7. The other seven women added the two dydrogesterone doses in reverse sequence. No dydrogesterone was taken during months 8 and 9. Lipids and lipoproteins were measured before treatment and at the end of months 4, 7 and 9. Lipids were also estimated in an untreated (reference) group of eight postmenopausal women on two occasions 6 months apart; these showed significant changes in HDL2- and HDL3-cholesterol. In the treatment group, HDL-cholesterol and apolipoprotein (apo) Al were significantly higher and LDL-cholesterol and apo B were significantly lower at months 4, 7 and 9 compared with baseline values. Triglyceride levels were increased significantly over baseline values, but remained within the normal range. No significant differences between the two dydrogesterone doses were observed on any lipid and lipoprotein fraction, nor were there any differences between the oestrogen-only and oestrogen/dydrogesterone treatment phases. Dydrogesterone appears to cause little, if any, lipid and lipoprotein changes and assessment in a larger population of postmenopausal women is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1990.tb02496.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    SENSITIVITY OF A DOUBLE-BLIND TRIAL OF RITODRINE AND PLACEBO IN TWIN PREGNANCY (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A critical examination is made of the results of a recently reported double blind trial comparing ritodrine and placebo. It is shown that interval estimates are more informative than p-values obtained from significance tests and that the trial involving 49 patients was insensitive to differences which could be clinically important. Contrary to the conclusions presented, the data suggest that further evaluation of the effects of ritodrine in twin pregnancies is necessary to clarify the situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04566.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Chi-squared Tests, Critical Ellipses and Computer Graphics (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Teaching statistics 9 (1987), S. 0 
    Details
    ISSN: 1467-9639
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9639.1987.tb00828.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Fractures of the acromion in young children and a description of a variant in acromial ossification which may mimic a fracture (1994)
    Springer
    Pediatric radiology 24 (1994), S. 251-255 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on six children, from 2 to 19 months old, with a defect across the root of the acromion (basiacromion) diagnosed as a fracture in four and as an anatomical variant (separate ossification center for the lateral half of the basiacromion) in the other two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015447
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Assessing robustness of crossover designsto subjects dropping out (1999)
    Springer
    Statistics and computing 9 (1999), S. 219-227 
    Details
    ISSN: 1573-1375
    Keywords: A-criterion ; crossover experiments ; dropout ; missing value ; MV-criterion ; Williams squares
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract In some crossover experiments, particularly in medical applications, subjects may fail to complete their sequences of treatments for reasons unconnected with the treatments received. A method is described of assessing the robustness of a planned crossover design, with more than two periods, to subjects leaving the study prematurely. The method involves computing measures of efficiency for every possible design that can result, and is therefore very computationally intensive. Summaries of these measures are used to choose between competing designs. The computational problem is reduced to a manageable size by a software implementation of Polya theory. The method is applied to comparing designs for crossover studies involving four treatments and four periods. Designs are identified that are more robust to subjects dropping out in the final period than those currently favoured in medical and clinical trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008974031782
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    Paper (German National Licenses)
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