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  • 1
    Electronic Resource
    Electronic Resource
    Regulation of Actin and Its mRNA by Thyroid Hormones in Cultures of Fetal Human Brain During Second Trimester of Gestation (1997)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 69 (1997), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of thyroid hormones (THs) on the expression of actin gene during fetal human brain development and the period of sensitivity to the hormones have been investigated. Developmental profile of actin in the cytoskeletal (CSK) and noncytoskeletal (non-CSK) fractions in the fetal cerebra showed a pronounced rise in the level of CSK actin at weeks 17–19. Northern blot analysis also revealed a sharp rise in the level of actin mRNA at weeks 16–18, temporally coinciding with the period of rise of THs and peak expression of TH receptors in the fetal brain. In organ cultures of weeks 13–23 fetal cerebra, THs elicited a general stimulation of CSK proteins at all ages studied with a preferential effect on actin at weeks 17–19. During this period, THs also stimulated the rate of synthesis of actin. Kinetics of induction of actin by TH in the non-CSK and CSK fractions in organ cultures of week 17 fetal cerebra showed an increased level of actin in both fractions within 1 h. Subsequently (at 5 and 18 h), induction was evident only in the insoluble CSK fraction, suggesting an effect of the hormone on the intracellular distribution of actin between the soluble non-CSK fraction and the insoluble CSK fraction. Correspondingly, in cultures of week 17 fetal cerebra, THs elicited an increase in actin mRNA level within 30 min of hormonal exposure. The overall results suggest that THs regulate the expression of actin gene by stimulating the rate of synthesis as well as intracellular distribution of actin during the mid phase of the second trimester of gestation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1997.69031170.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tubulin and Glial Fibrillary Acidic Protein Gene Expression in Developing Fetal Human Brain at Midgestation (1999)
    Springer
    Neurochemical research 24 (1999), S. 637-641 
    Details
    ISSN: 1573-6903
    Keywords: Tubulin ; glial fibrillary acidic protein ; gene expression ; human fetal brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Developmental alterations in the expression of glial fibrillary acidic protein (GFAP) and α-tubulin were examined at the level of mRNA and protein in human fetal brain between weeks 13–23 of gestation. Except for a transient increase at week 15, GFAP expression in the cytoskeletal (CSK) fraction was low until week 17, when it increased steadily to week 23, corresponding to the phase of glial proliferation. The developmental profile of α-tubulin in the CSK fraction displayed a biphasic pattern, with an initial rise between weeks 13–16 coinciding with the early phase of neuroblast multiplication, and a second rise between weeks 17–23 corresponding to the phase of glial proliferation. No significant difference in the spatial distribution of α-tubulin was found in different region of brain but GFAP expression varied with a higher level in cerebellum than that in cerebrum at late midgestation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021096224161
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  • 3
    Electronic Resource
    Electronic Resource
    The Lyme disease agent exploits a tick protein to infect the mammalian host (2005)
    [s.l.] : Nature Publishing Group
    Nature 436 (2005), S. 573-577 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Lyme disease agent, Borrelia burgdorferi, is maintained in a tick–mouse cycle. Here we show that B. burgdorferi usurps a tick salivary protein, Salp15 (ref. 3), to facilitate the infection of mice. The level of salp15 expression was selectively enhanced by the presence of B. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature03812
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