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  • 1
    Electronic Resource
    Electronic Resource
    Plasma adenosine 3′, 5′-cyclic monophosphate: Dose-response to injected bovine parathyroid hormone in man (1976)
    Springer
    Calcified tissue international 22 (1976), S. 332-335 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064092
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  • 2
    Electronic Resource
    Electronic Resource
    The Relationship Between Phalangeal Bone Density and Vertebral Deformities (2000)
    Springer
    Calcified tissue international 66 (2000), S. 1-4 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Radiographic absorptiometry — Hand — Vertebral deformities — Bone mineral density.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Radiographic absorptiometry (RA) of the phalanges is a convenient and reliable technique for measuring bone mineral density (BMD). It needs only a radiograph of the hand, which can be sent for evaluation to a central facility, whereas other techniques require specialized equipment. We assessed the relationship between RA measurements and the presence of vertebral deformities in a population-based cohort of postmenopausal women, and to compare the results with simultaneously obtained BMD of the hip by dual-energy X-ray absorptiometry (DXA). A total of 389 women aged 55–84 (mean age 67.2 years, SD 8.7) were randomly selected from a large general practice. RA, DXA of the hip, and vertebral deformities in the lateral spine X-rays by vertebral morphometry were assessed. Thirty-eight women (9.8%) had severe (grade II) vertebral deformities, and their BMD at the phalanges and femoral neck was significantly lower than that of women without severe vertebral deformities. Odds ratios for the presence of severe vertebral deformities of 1.5 (95% CI: 1.1–2.1) for RA and 1.3 (95% CI: 0.9–1.9) for DXA, together with similar receiver operating characteristics curves, were found using age-adjusted logistic regression. Phalangeal BMD is related to vertebral deformities at least as closely as BMD of the femoral neck BMD. RA may therefore help to evaluate fracture risk, especially if no DXA equipment is available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230050001
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Bisphosphonates in osteoporosis? (1993)
    Springer
    Osteoporosis international 3 (1993), S. 230-236 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01621915
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The Prevalence of Low Bone Mineral Density in Dutch Perimenopausal Women: The Eindhoven Perimenopausal Osteoporosis Study (1998)
    Springer
    Osteoporosis international 8 (1998), S. 404-409 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bone mineral density – Estrogens – Hysterectomy – Menopause – Osteopenia – Osteoporosis –
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The aim of this study was to estimate the prevalence of osteopenia and osteoporosis in perimenopausal women, and to assess determinants of low bone mineral density (BMD). All women born between 1941 and 1947 (aged between 46 and 54 years) living in the city of Eindhoven were invited to participate in the study; 5896 white Dutch women, representing 73% of the total number of Dutch women in this age group, were studied. Of these, 24% were using estrogen preparations and 19% had undergone hysterectomy, with or without oophorectomy. All women were interviewed and bone mineral density (BMD) of the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). Osteopenia and osteoporosis were defined according to the criteria proposed by a WHO working group. In the population studied the prevalence of osteopenia and osteoporosis was 27.3% and 4.1%, respectively. With progression from premenopause to menopause, the prevalence of osteoporosis increased from 0.4% to 12.7%, and that of osteopenia from 14.5% to 42.8%. An increased risk for low BMD (osteopenia and osteoporosis) was associated with age, menopausal status and smoking, while alcohol consumption, high body mass index (BMI) and use of estrogens had a protective effect. This study of a large population-based cohort of perimenopausal women revealed a high prevalence of low bone mass and, therefore, a higher risk for osteoporotic fractures. The data further suggest that, when issues on the long-term efficacy and safety of preventive treatments are resolved, it may be possible to identify women at higher risk who are most likely to benefit from screening strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050083
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  • 5
    Electronic Resource
    Electronic Resource
    Usefulness of Armspan and Height Comparison in Detecting Vertebral Deformities in Women (1999)
    Springer
    Osteoporosis international 9 (1999), S. 129-133 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Armspan – Height – Osteoporosis – Vertebral deformities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The prevalence of vertebral fractures in women increases with age but only about one third of these fractures are symptomatic. On the other hand, the presence of vertebral fractures is an independent risk factor for new osteoporotic fractures. In the present study we examined the hypothesis that differences between armspan and height are related to the presence of vertebral deformities in a cohort of 494 women aged between 55 and 84 years (mean age 67.6 years, SD 8.2 years) who were randomly selected from a large general practice in The Netherlands. Height and armspan were measured and vertebral morphometry of lateral radiographs of the spine was performed. Both height and armspan decreased significantly with age. The correlation between armspan and height was 0.83. Vertebral deformities were present in 32.7% of the women (grade I in 22.4% and grade II in 10.3%). Only the prevalence of grade II deformities rose with age. The variation of the difference between armspan and height in the groups with or without grade II vertebral deformities was comparable and relatively large (range 〉15 cm). The difference in mean values was small between those groups (1.6 cm) and could not differentiate between women with and without vertebral deformities. Our data show that the presence of vertebral deformities cannot be detected by the difference between armspan and height.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050125
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  • 6
    Electronic Resource
    Electronic Resource
    Uninterrupted oral bisphosphonate (pamidronate) therapy of patients with osteoporosis is not associated with chronic stimulation of parathyroid hormone secretion (1995)
    Springer
    Osteoporosis international 5 (1995), S. 93-96 
    Details
    ISSN: 1433-2965
    Keywords: Bisphosphonates ; Osteoporosis ; Pamidronate ; Parath yroid hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously reported that long-term uninterrupted treatment of patients with osteoporosis with oral pamidronate is associated with increases in bone mineral content (BMC) of the lumbar spine which could not be explained by the antiresorptive action of the drug alone, raising the possibility of an additional effect of the treatment on skeletal tissue. Administration of suppressive doses of the bisphosphonate to patients with excessive osteoclastic resorption is followed by transient decreases in serum calcium and increases in parathyroid hormone (PTH) concentrations. It is possible, therefore, that chronic pamidronate therapy may stimulate PTH secretion, which in turn has been previously shown to have anabolic effects on the skeleton. To test this hypothesis we examined the changes in serum calcium, PTH and phosphate concentrations every 6 months in 33 patients with vertebral osteoporosis and no biochemical evidence of increased bone turnover, treated with oral pamidronate 150 mg daily. Serum alkaline phosphatase and urinary hydroxyproline excretion decreased significantly by 20% and 28%, respectively, after 6 months of treatment and remained at this level for the following 18 months. These changes were associated with significant increases in spinal BMC, as expected. Serum calcium, PTH and phosphate did not change from baseline values either in the whole group or when the patients were divided according to the use or not of calcium supplements. Our results exclude chronic stimulation of PTH secretion as a factor contributing to long-term increases in bone mass in patients with osteoporosis and adequate calcium intake during continuous oral pamidronate therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623309
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  • 7
    Electronic Resource
    Electronic Resource
    Report on Osteoporosis in the European Community: Current Status and Recommendations for the Future (1998)
    Springer
    Osteoporosis international 8 (1998), S. 531-534 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050094
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  • 8
    Electronic Resource
    Electronic Resource
    Bone Histomorphometric Evaluation of Pamidronate Treatment in Clinically Manifest Osteoporosis (1999)
    Springer
    Osteoporosis international 9 (1999), S. 489-493 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Histomorphometry – Osteoporosis – Pamidronate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The effect of pamidronate therapy on bone histology was studied in patients with osteoporosis with at least one vertebral fracture in a randomized, double-masked, placebo-controlled, multi-center trial. Patients received pamidronate 150 mg/day or placebo in addition to calcium 500 mg/day and vitamin D3 400 IU/day. Transiliac bone biopsies were obtained before and after 1 or 2 years of treatment. Of these, 23 pairs of biopsies obtained from 14 women and 9 men (mean age þ SD, 61.5 þ 10 years) were of sufficient quality for histomorphometry. Histomorphometry was performed on sections stained with Goldner’s trichrome, using a drawing tube and a digitizer. Urinary hydroxyproline excretion decreased significantly (p〈0.005) following pamidronate treatment, indicating a decrease in bone resorption. Osteoid volume and osteoid surface also decreased significantly in the pamidronate group (p〈0.004 and p〈0.003 respectively), consistent with a secondary decrease in bone formation. Osteoid variables did not change in the placebo-treated patients. Cortical thickness, trabecular bone volume and trabecular thickness did not change after pamidronate or placebo treatment. Wall thickness, however, showed a borderline increase following pamidronate treatment. After pamidronate, eroded surface and mineral apposition rate did not change significantly in the placebo and pamidronate groups. Mineralizing surface and activation frequency showed a borderline decrease in the placebo and pamidronate groups. The decrease in mineralization lag time was of borderline significance in the pamidronate group, corroborating the absence of any negative effect on mineralization. In conclusion, pamidronate treatment led to a decrease in bone turnover and did not interfere with bone mineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050175
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  • 9
    Electronic Resource
    Electronic Resource
    Regulation of calcium absorption by 1,25,dihydroxy-vitamin D—Studies of the effects of a bisphosphonate treatment (1982)
    Springer
    Calcified tissue international 34 (1982), S. 317-320 
    Details
    ISSN: 1432-0827
    Keywords: 1,25-Dihydroxy-vitamin D ; Calcium absorption ; Parathyroid hormone ; Bisphosphonate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary In 10 patients with Paget's disease of bone and 2 patients with osteoporosis, we studied the effects of hypocalcemia and hypophosphatemia induced by disodium-(3-amino-1-hydroxypropylidene)-1,-bisphosphonate (APD) treatment on the serum concentration of PTH and 1,25-dihydroxyvitamin D [1,25(OH)2D3] and on calcium absorption and balance. The fall in serum calcium and phosphate was associated with a rise in the serum concentration of PTH and 1,25(OH)2D3, coupled with increases in net calcium absorption and calcium balance. The concentration of 1,25(OH)2D3 was significantly related (P〈0.001) to the serum calcium (r=0.66), the serum phosphate (r=0.78), and the serum PTH (r=0.71), confirming the interrelated control of these parameters on 1,25(OH)2D3 production. Moreover, the rise in 1,25(OH)2D3 caused an appropriate rise in calcium absorption (r=0.74) and calcium balance (r=0.86), showing that this vitamin D metabolite contributes as a hormone to calcium homeostasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411260
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  • 10
    Electronic Resource
    Electronic Resource
    Treatment of osteogenesis imperfecta with the bisphosphonate olpadronate (dimethylaminohydroxypropylidene bisphosphonate) (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 792-794 
    Details
    ISSN: 1432-1076
    Keywords: Key words Bisphosphonates ; Osteogenesis imperfecta ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Osteoporosis is an important feature of osteogenesis imperfecta (OI). So far, no effective medical treatment is available. We treated three boys with severe OI type III and vertebral deformities for 5–7 years with continuous oral administration of the bisphosphonate, olpadronate. Treatment resulted in a decreased number of bone fractures, an increased calcification of the long bones and an amelioration of vertebral shape. No side-effects were encountered. Conclusion These preliminary but long-term obser- vations suggest that the bisphosphonate olpadronate may be a useful treatment for patients with OI and vertebral fractures. Bisphosphonates may be promi- sing drugs for children with OI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050715
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