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  • 1
    Electronic Resource
    Electronic Resource
    Biosynthesis of the macrolide antibiotic chlorothricin: basic building blocks (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 556-560 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00596a029
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A nicotinamide adenine dinucleotide (phosphate) glycohydrolase [NAD(P)ase, EC 3.2.2.6] from Streptomyces griseus (1979)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 6 (1979), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1979.tb03713.x
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  • 3
    Electronic Resource
    Electronic Resource
    Production of tylosin and nikkomycin by immobilized Streptomyces cells (1982)
    Springer
    Applied microbiology and biotechnology 15 (1982), S. 206-210 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Mycelia of Streptomyces sp. T 59-235 and Streptomyces tendae Tü 901 (producing the antibiotics tylosin and nikkomycin, resp.) were immobilized in different carriers. With both organisms best antibiotic production was observed in calcium alginate gel. Influence of aeration, cell density and flow rate on antibiotic production was investigated in batch fermentation and in a continuous system (air-bubbled reactor). In batch fermentation, immobilization prolongued the production phase from 72 to 120 h (Streptomyces T 59-235) and from 72 to 96 h (S. tendae). The relative productivity of immobilized cells was 40 to 50% compared to that of free mycelia in both cases. In continuous tylosin fermentation highest production rate was observed in a medium nearly saturated with oxygen. Nikkomycin production by immobilized S. tendae could be maintained for longer than 350 h in a continuous system. The production rate depended on cell density and flow rate of the medium. The maximum specific productivity was 100% compared to that of free mycelium in batch culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499956
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  • 4
    Electronic Resource
    Electronic Resource
    Production of nikkomycin by immobilized Streptomyces cells — Physiological properties (1984)
    Springer
    Applied microbiology and biotechnology 19 (1984), S. 146-152 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The antibiotic nikkomycin can be produced by calcium alginate immobilized mycelium of Streptomyces tendae Tü 901 in batch and continuous culture. Scanning electron micrographs show the porous structure of the matrix and the distribution of the cells in the gel. Some physiological properties of free and immobilized mycelia were compared. Immobilization does not change the relative amounts of nikkomycin compounds in the culture broth. DNA and protein content were the same in free and immobilized cells. The specific activity of fructosediphosphate aldolase dropped during fermentation and was lower for entrapped than for free cells. The specific activity of mannitol dehydrogenase increased up to the end of the fermentation and was the same for free and immobilized mycelium. In continuous culture the relative amount of mannitol consumed decreased with increasing flow rate. When the medium was supplemented with amino acids mannitol consumption increased significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256445
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  • 5
    Electronic Resource
    Electronic Resource
    Relationship between macrotetrolide production and specific activity of some hydrolases in a high and a low producing strain of Streptomyces griseus (1981)
    Springer
    Applied microbiology and biotechnology 11 (1981), S. 216-221 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The activities of five hydrolytic enzymes in the culture filtrate and in cell-free extracts from strains of Streptomyces griseus, differing in macrotetrolide production, have been determined over a fermentation period of 200 h. The specific activities of phosphatase, phosphodiesterase, and adenosine triphosphatase in the medium, and phosphatase and phosphodiesterase in the cell-free extract were lower in the low than in the high producing strain. No significant difference was found between the strains, for adenosine triphosphatase and protease activity in the cell-free extract or protease activity in the medium. The specific activity of esterase was higher in the low than in the high producing strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505870
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  • 6
    Electronic Resource
    Electronic Resource
    Regulation of tylosin synthesis in Streptomyces: Effects of glucose analogs and inorganic phosphate (1979)
    Springer
    Applied microbiology and biotechnology 7 (1979), S. 365-370 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Glucose, 2-deoxy glucose and inorganic phosphate inhibited tylosin production and fatty acid oxidation in Streptomyces T 59–235. Glucose-6-phosphate was accumulated in high-phosphate cultures. The possible function of glucose phosphate as a common mediator of both glucose and phosphate effects is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499851
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  • 7
    Electronic Resource
    Electronic Resource
    Formation of secondary metabolism enzymes in the tylosin producerStreptomyces T59-235 (1982)
    Springer
    Archives of microbiology 131 (1982), S. 170-173 
    Details
    ISSN: 1432-072X
    Keywords: Tylosin ; Phosphate regulation ; Streptomyces ; dTDP-D-glucose-4,6-dehydratase ; dTDP-mycaroseforming enzyme system ; SAM: macrocin-O-methyl transferase ; Translation/transcription inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Production of the macrolide antibiotic tylosin byStreptomyces T59-235 was inhibited in cultures containing high phosphate concentrations (30 mM Pi). Vegetative growth (dry weight increase, DNA and RNA synthesis) was hardly affected. Tylosin production began when macromolecule synthesis had slowed down to minimum level; in cultures with 30 mM Pi the onset of antibiotic production was retarded compared to cultures with low phosphate concentration (5 mM). The activities of three enzyme systems involved in tylosin biosynthesis (dTDP-D-glucose-4,6-dehydratase; dTDP-mycarose-forming enzyme system; SAM: macrocin-O-methyl transferase) were measured and found to be significantly lower in cultures with 30 mM Pi than in low phosphate cultures. Chloramphenicol, but not rifampicin, caused a rapid decrease of both tylosin formation rate and dTDP-D-glucose-4,6-dehydratase activity when added to tylosin producing cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01054001
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