ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
To develop a suitable scaffold optimizing bone regeneration, we developed bovinebone ash derived fully connected porous HA ceramic scaffolds adopting a foaming method.They revealed excellent biocompatibility. The attached cells on the scaffolds proliferated inmulti-layers with osteoblastic differentiation. The bone defects grafted with bovine bone ashderived fully interconnected porous HA ceramics having average 500 μm sized spherical poresand average 150 μm sized interconnecting interpores with average 80% porosity were favorablyhealed without any pathologic changes within 3 weeks. New bone ingrowth with excellentosteoconduction through the spherical pores along the inner surface was noted from 1 weekafter implantation. Each spherical pore was filled with hematopoietic marrow and newly formedbone which with time was well integrated with the porous HA ceramic scaffold with time.These findings suggest that the bovine bone ash-derived fully interconnected porous HAceramic formed by foaming method can be a promising bone substitute and a scaffold for bonetissue engineering
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.633.pdf
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