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  • 1
    Electronic Resource
    Electronic Resource
    Neurofibromatosis 2 (Bilateral Acoustic or Central Neurofibromatosis), a Treatable Cause of Deafness (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 630 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb19615.x
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  • 2
    Electronic Resource
    Electronic Resource
    Sites of [3H]taurine Uptake in the Rat Substantia Nigra in Relation to the Release of Taurine from the Striatonigral Pathway (1990)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 2 (1990), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The autoradiographic localization of radiolabelled taurine taken up in the rat substantia nigra in vivo together with conditions of release of the [3H]taurine taken up into brain slices were studied to determine whether they are consistent with the hypothesis that taurine may act as a neurotransmitter in the striatonigral pathway.At the light microscopic level the main cellular elements that became radiolabelled following the injection of [3H]taurine into the substantia nigra could be identified as glial cells. Electron microscope autoradiography confirmed that a subpopulation of glial cells including astrocytes, pericytes, and oligodendrocytes were radiolabelled and that neuronal perikarya were not radiolabelled. In addition, axonal elements including both terminal and preterminal boutons were found to have silver grains overlying them and were thus considered to be radiolabelled. This was supported by a quantitative analysis of the distribution of the silver grains; whereas glial elements had a significantly higher number of grains associated with them than with any other structure, axonal elements had a significantly greater number of grains than dendritic structures.Release of the preloaded [3H]taurine from superfused slices of substantia nigra occurred in response to veratridine, was calcium-dependent and was sensitive to inhibition by high magnesium concentrations or tetrodotoxin. Following the destruction of neurons in the striatum by ibotenic acid injections, although the weight of the ipsilateral substantia nigra was reduced, the uptake of [3H]taurine was not altered. In contrast to this, the veratridine-stimulated release was markedly attenuated, implying that the destruction of striatal neurons causes the loss of sites in the substantia nigra from which exogenous taurine is released.These results add further support to previous suggestions that taurine might act as a neurotransmitter or neuromodulator in the striatonigral pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1990.tb00380.x
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic Linkage Analysis of Neurofibromatosis with DNA Markers (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 486 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb48083.x
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  • 4
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    Unknown
    Holiness as service: "Therapeia" and "hyperetike" in Plato's "Euthyphro" (1994)
    The Hague : Periodicals Archive Online (PAO)
    The Journal of Value Inquiry. 28:4 (1994:Dec.) 529 
    Details
    ISSN: 0022-5363
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:n252-1994-028-04-000003
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  • 5
    Electronic Resource
    Electronic Resource
    The parental origin of new mutations in neurofibromatosis 2 (2000)
    Springer
    Neurogenetics 3 (2000), S. 17-24 
    Details
    ISSN: 1364-6753
    Keywords: Key words Parental origin ; Neurofibromatosis 2 ; Allele loss ; Mosaicism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Neurofibromatosis 2 (NF2) is an autosomal dominant disorder characterized by schwannomas and meningiomas that develop after inactivation of both copies of the NF2 gene. Approximately half of all patients with NF2 have unaffected parents and the disease results from new mutations at the NF2 locus. Loss of heterozygosity (LOH) in tumor specimens due to deletions covering the normal NF2 allele can be used to infer the haplotypes surrounding underlying mutations and determine the allelic origin of new mutations. We studied 71 sporadic NF2 patients using both LOH and pedigree analysis and compared the parental origin of the new mutation with the underlying molecular change. In the 45 informative individuals, 31 mutations (69%) were of paternal and 14 (31%) were of maternal origin ( P =0.016). Comparison with corresponding constitutional mutations revealed no correlation between parental origin and the type or location of the mutations. However, in 4 of 6 patients with somatic mosaicism the NF2 mutation was of maternal origin. A slight parent of origin effect on severity of disease was found. Further clinical and molecular studies are needed to determine the basis of these unexpected observations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100480000088
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  • 6
    Electronic Resource
    Electronic Resource
    Immunocytochemical localisation of prolactin and growth hormone in the perinatal sheep pituitary (1979)
    Springer
    Cell & tissue research 197 (1979), S. 501-514 
    Details
    ISSN: 1432-0878
    Keywords: Prolactin cells ; Growth hormone cells ; Secretory granules ; Size range (quantitative analysis) ; Perinatal sheep pituitary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The peroxidase anti-peroxidase immunocytochemical staining technique has been used to identify prolactin and growth hormone cells in pituitaries from fetal and neonatal sheep. The size of the secretory granules in these cell types has been measured using the image analysing computer Quantimet 720. The area size distributions of the fetal prolactin and growth hormone granules were compared with those in the neonate and the adult. It appears that the gestational age of the fetus may influence the size range of prolactin secretory granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233573
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  • 7
    Electronic Resource
    Electronic Resource
    Immunocytochemical localisation of prolactin and growth hormone in the ovine pituitary (1978)
    Springer
    Cell & tissue research 194 (1978), S. 327-336 
    Details
    ISSN: 1432-0878
    Keywords: Prolactin ; Growth hormone ; Ovine pituitary ; Immunocytochemistry ; Granule size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using the peroxidase-antiperoxidase immunocytochemical staining technique, prolactin and growth hormone cells have been identified and described in the ovine pituitary. The image analysing computer, Quantimet 720, was used to assess accurately the size range of the secretory granules in these cell types. The area size distributions of the prolactin and growth hormone granules are similar. An increased proportion of larger granules was observed in the prolactin cells post-partum. Serial sections stained alternately for prolactin or growth hormone confirmed that the cells contain either prolactin or growth hormone but not both.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220399
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  • 8
    Electronic Resource
    Electronic Resource
    Immunocytochemical studies on the LHRH system of the Japanese quail: influence by photoperiod and aspects of sexual differentiation (1988)
    Springer
    Cell & tissue research 253 (1988), S. 327-335 
    Details
    ISSN: 1432-0878
    Keywords: LHRH-neurons ; Sexual differentiation ; Photoperiodism ; Hypothalamus ; Septum ; Japanese quail
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunocytochemistry was used to determine if photoperiod and/or sex have any effect on the pattern of the luteinizing hormone-releasing hormone (LHRH) system in the brain of the Japanese quail. Immunopositive perikarya were found within three major areas of the brain: the rostral paraolfactory lobe, the preoptic, and the septal region. A quantitative analysis of LHRH cell numbers was performed on male and female quail after two photoperiodic treatments: sexually mature birds exposed to 24 weeks of 20 h light: 4 h darkness (20L∶4D), and birds with a regressed reproductive system (induced by transfer from a photoregime of 20L∶4D to 25 short days of 8L∶16D). Two-way analysis of variance showed that short-day males display significantly (p 〈 0.05) more immunopositive perikarya (607 + 134) than long-day males (291 + 114), short-day females (293 + 103) or long-day females (330 + 92). The density of LHRH-immunoreactive nerve fibres and the intensity of the immunostaining in the median eminence were always greater in long-day sexually mature quail (male and female) than in animals exposed to 25 days of 8L∶16D. These results demonstrate that the LHRH system of the quail is influenced by photoperiod and mirrors sexual differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222289
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