ISSN:
0570-0833
Keywords:
Inversion barriers
;
Inversion barriers
;
Conformation analysis
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Conformational conversions of N-methylazacyclohexanes are of particular interest: they can proceed either via ring- or nitrogen-inversion processes. In both procedures an equatorial N-methyl group is converted into an axial one, and the converse. It is appropriate to dissociate the energy barriers for N-methyl inversion into two “half-barriers” for the steps, axial form → transition state and equatorial form → transition state, and to report both values separately. - In this article the N-methyl inversion barriers of numerous methylated oligoazacyclohexanes, including species with oxygen or nitrogen atoms in the ring, are discussed.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.198105211
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