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  • 1
    Electronic Resource
    Electronic Resource
    The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. II. The relationship between increase of cell volume and histamine release (1978)
    Springer
    Inflammation research 8 (1978), S. 315-323 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ionophore X537A induced swelling of isolated rat mast cells parallel to histamine release. Both actions were depressed by extracellular calcium and BSA, temperatures below 37°C, NEM, PMSF, and TTX, and were enhanced by high potassium and pretreatment of the cells with ATP. DSCG, theophylline, and DFP enhanced the histamine release noted after 10 min of incubation without influencing the swelling action of X537A. The swelling action could not be separated from histamine release and it is suggested that it right be inherent in the mechanism of secretion induced by X537A. The present results further distinguish histamine release induced by the two ionophores X537A and A23187.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968610
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  • 2
    Electronic Resource
    Electronic Resource
    The significance of divalent cations for the release of histamine from isolated rat mast cells (1975)
    Springer
    Inflammation research 5 (1975), S. 455-455 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972667
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  • 3
    Electronic Resource
    Electronic Resource
    Calcium-dependent histamine release from isolated rat mast cells induced by sodium fluoride—A two-step reaction (1978)
    Springer
    Inflammation research 8 (1978), S. 403-404 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The release process induced by fluoride and calcium can be divided into two separate steps. A slow activating step induced most likely by binding of fluoride to the cells and an energy-dependent secretory step induced by calcium. This opens possibilities for further studies as to the nature of individual steps of the secretory process of histamine from isolated rat mast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968650
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  • 4
    Electronic Resource
    Electronic Resource
    On the mechanism of histamine release induced by thapsigargin fromThapsia garganica L. (1979)
    Springer
    Inflammation research 9 (1979), S. 53-57 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thapsigargin (Tg) is a pure chemical compound isolated fromThapsia garganica with a molecular weight of 650. It releases histamine from isolated rat mast cells but not from isolated histamine-retaining mast cell granules. The rate of release is markedly influenced by pretreatment of mast cells with Tg prior to the addition of calcium. In agreement with the effect of the ionophore A23187 but in contrast to many other calcium-dependent histamine-releasing agents, cells preincubated with Tg respond to the secretory action of calcium whenever the ion is introduced. However, after dilution of Tg-pretreated cells histamine release induced by the addition of calcium became dependent on the time of its addition. The secretory reaction induced by Tg and calcium can be divided into a two-step reaction at 37°C. Pretreatment of mass cells with Tg renders the cells insensitive to the secretory action of compound 48/80 in the absence of calcium, and this effect could be partly counteracted if 1 mM of strontium was added together with compound 48/80. It is concluded that among various calcium- and energy-dependent histamine-releasing agents Tg most closely resembles the action of fluoride on isolated rat mast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024109
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  • 5
    Electronic Resource
    Electronic Resource
    Studies on the action of the calcium ionophore A 23187 on isolated rat mast cells (1974)
    Springer
    Inflammation research 4 (1974), S. 200-201 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01970279
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  • 6
    Electronic Resource
    Electronic Resource
    On the inhibitory action of DFP and PMSF on histamine release from isolated rat mast cells (1977)
    Springer
    Inflammation research 7 (1977), S. 110-111 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The present results furnish an alternative explanation to the inhibition of histamine release induced by so-called esterase inhibitors. The inhibition can well be explained on the basis that these agents inhibit metabolic energy production necessary for the coupling of stimulation to secretion in the rat mast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964897
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  • 7
    Electronic Resource
    Electronic Resource
    The action of various histamine releasing agents on the volume distribution of rat mast cells registered by the Coulter Channelyzer (1975)
    Springer
    Inflammation research 5 (1975), S. 465-465 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972677
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  • 8
    Electronic Resource
    Electronic Resource
    Swelling as a possible mechanism of action of X537A to release histamine from rat mast cells (1978)
    Springer
    Inflammation research 8 (1978), S. 387-387 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions The present results strengthen the view that the mechanism of histamine release induced by X537A is different from that induced by agents which depend on calcium and metabolic energy for their action. The swelling of the cells seems to be inherent in the secretory action of X537A on rat mast cells. The fact that X537A is a carrier of monovalent cations [4] can well explain its swelling action and might be the ultimate reason for release. The possibility of a more active role of X537A as an aminophore [4] must be taken into account and is under further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968629
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  • 9
    Electronic Resource
    Electronic Resource
    Monovalent cation-dependent histamine release from rat peritoneal mast cells by ionophore X537A (1978)
    Springer
    Inflammation research 8 (1978), S. 394-395 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions The results indicate that X537A exerts its histamine-releasing action only in the presence of monovalent cations. The release is not dependent on either extra- or intracellular calcium, in fact extracellular calcium depressed the release. The finding that the release occurred faster in a potassium medium indicates that high potassium increased the permeability of the plasma membrane for X537A or that X537A carries potassium more efficiently over the cell membrane as compared to sodium, in spite of the finding that the affinity of X537A is of the same order for both cations [5]. According to the latter possiblity, monovalent cations would accumulate in the cell and be available for exchange with histamine bound to the granular matrix. Furthermore, the observation that lack of cellular metabolic energy slows down the release process might indicate that metabolic energy influences the penetration of X537A at limiting concentrations. The slow release of histamine induced by X537A in comparison to many calcium- and energy-dependent releasing agents further indicates a different type of mechanism for release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968639
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  • 10
    Electronic Resource
    Electronic Resource
    Mechanism of histamine release from rat peritoneal mast cells (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 948-953 
    Details
    ISSN: 1432-1440
    Keywords: Histamine release ; Rat peritoneal mast cells ; Mechanisms ; Histaminfreisetzung ; Peritonealmastzellen der Ratte ; Mechanismen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In dieser Arbeit wird versucht, die Mechanismen der Histaminfreisetzung aus Peritonealmastzellen der Ratte mit Hilfe selektiver Histaminliberatoren zu klären. Von den verschiedenen enzymatischen Mechanismen, die an der Sekretion beteiligt sind, werden folgende Prozesse im Detail betrachtet: die Ecto-ATP-ase Aktivität in der Mastzelle, die Proesterase-Esterase-Umwandlung während der Histaminsekretion, das cyclische AMP und die Mikrotubuli Assoziation/Dissoziation, die Phospholipase A2 und der Effekt von Phospholipidmetaboliten auf die Sekretion, die N-Methyltransferase und Methylierung von Phospholipiden und die Phosphorylierung und Dephosphorylierung von Proteinen.
    Notes: Summary The present communication endeavours to elucidate the mechanism of histamine release from rat peritoneal mast cells induced by selective histamine liberators. Of the different enzymatic processes involved in secretion the following are considered: ecto-ATPase activity in the mast cell, pro-esterase-esterase conversion during histamine secretion, cyclic AMP and microtubule association/dissociation, phospholipase A2 and the effect of phospholipid metabolites on secretion, N-methyl transferase and the methylation of phospholipids and the phosphorylation and desphosphorylation of proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716953
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