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  • 1
    Electronic Resource
    Electronic Resource
    Sleep apnea and pulmonary hypertension (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 131-134 
    Details
    ISSN: 1432-1440
    Keywords: Sleep apnea ; Pulmonary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pulmonary artery pressure values of 65 patients with sleep apnea syndrome were measured at rest and during ergometer exercise up to 100 W. Pulmonary hypertension at rest was found in 13, and during exercise in 31 more patients. Only 8 patients with pathological pressure findings suffered from pulmonary hypertension in combination with a pulmonary or cardiac disease. In the other 36 patients, no indication of a primary cause of pulmonary hypertension apart from sleep apnea syndrome could be found. Out of the 65 patients, 11 with a finding of more than 20 apnea episodes per hour's sleep underwent polysomnographic recordings in the sleep laboratory. The hemodynamic parameters were continuously measured. All 11 patients had a finding of severe sleep apnea with more than 300 apnea episodes during the night of recording. In 6 patients, the appearance of apnea episodes was accompanied by only moderate changes in pulmonary artery pressure. In 5 patients, there were critical increases in pulmonary artery pressure, which went along with increases in cardiac output and in pulmonary capillary wedge pressure. Increases in pulmonary vascular resistance were established in 3 out of these 5 patients, and a slight decrease in 2. The mechanism of hypoxic vasoconstriction of the pulmonary arteries may account for the pressure increases in 3 of our patients, but fails to explain the findings in the other 2 patients. Nocturnal changes in pulmonary artery pressure in patients with sleep apnea may therefore have different causes. Pulmonary hypertension constitutes a severe complication in patients with sleep apnea. As 55% of all sleep apnea patients were found to suffer from pulmonary hypertension without any indication of a primary pulmonary or cardiac disease, the possibility that pulmonary hypertension results should not be underestimated in patients with suspected sleep apnea syndrome. Measurements of the pulmonary artery pressure must therefore be included in the examination regimen of such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732637
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  • 2
    Electronic Resource
    Electronic Resource
    Langzeitregistrierung und Zeitreihenanalyse in der Inneren Medizin (1997)
    Springer
    Der Internist 38 (1997), S. 734-741 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Langzeitregistrierung ; Langzeit-EKG ; Langzeit-Blutdruck ; Monitoring ; Polysomnographie ; Zeitreihenanalyse ; Computerauswertung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Langzeitregistrierungen gehören heute in den verschiedensten Fächern zum Repertoire der Diagnostik in der Inneren Medizin: Langzeit-EKG, Langzeit-Blutdruck, Oximetrie, ösophageale pH-metrie, Langzeit-EEG und Polysomnographie mit ihren Begleitparametern. Das Monitoring von Vitalparametern in der internistischen Intensivmedizin stellt einen zweiten großen Bereich der Langzeitregistrierungen dar. Allen Langzeitregistrierungen gemeinsam ist die anfallende Datenflut. Diese muß auf die für die Diagnostik wesentliche Information reduziert werden. Mit der heute vorhandenen und verbreiteten Computertechnik stehen die technischen Voraussetzungen zur Lösung dieser Aufgaben zur Verfügung. Die Werkzeuge der Zeitreihenanalyse dienen der Datenreduktion, der Analyse und der Visualisierung. Das Ziel der Zeitreihenanalyse besteht darin, pathophysiologische Muster korrekt zu erkennen, übersichtlich darzustellen und beim intensivmedizinischen Monitoring die richtigen Alarme auszulösen. Die Praxis zeigt, daß dieses Ziel erst teilweise erreicht ist. Weiterhin wird versucht mit Methoden der Zeitreihenanalyse den Übergang von physiologischer Regulation und Funktion zu pathologischer Dysfunktion zu untersuchen, um eine Trennung bzw. Therapieempfehlung nicht an willkürlich festgelegte Grenzwerte zu knüpfen. Hier soll die physiologische Variabilität der Signale mit in die Bewertung einbezogen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050084
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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