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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 75 (1987), S. 384-387 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A method of genetic analysis is presented which involves digestion of DNA with a single restriction enzyme (PvuII) and hybridisation with a mixture of five probes. Four of the five probes chosen recognise hypervariable regions (HVRs) of the human genome and hence an allele-specific DNA identity pattern results. An advantage of this approach to genetic characterisation is that the complex identity patterns may be broken down into simple allelic systems of known chromosomal localization by hybridisation with the individual probes. Also different probes may be included in a combined probe designed for particular types of investigation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 5 (1990), S. 236-240 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions The majority of people with infective diarrhoea, i.e. those with food poisoning or “traveller's diarrhoea”, are relatively straightforward and will usually settle with rehydration and observation. The main problems in the field of infectious diarrhoea are with differential diagnosis, particularly from inflammatory bowel disease. Controversy surrounds the use of anti-diarrhoeal agents and the role of empiric antibiotics has yet to be defined. Finally, the place of the surgery in the management of these conditions can be very difficult but a conservative approach to surgical intervention is probably the best option. New pathogens as causative agents of diarrhoea are found every few years. The demand for mass-produced and quick-cook foods is increasing and the rules regarding the preparation and storage of food are often not followed. Also, travel is becoming easier and many more people are visiting developing countries. For these reasons and others it is likely that the problem of infective diarrhoea will continue to increase in the future. In addition to elucidating the pathogenesis of various forms of infective diarrhoea, future research will be directed towards prevention, earlier diagnosis and the development of better medical therapies for this problem.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The a+-thalassaemias are usually caused by the deletion of one of the linked pair of a-globin genes on chromosome 16 (ref. 5). The normal genotype is represented by aa/aa. Heterozygotes (á€"a/aa) are clinically normal, whereas homozygotes (á€"a/- a) have a mild ...
    Type of Medium: Electronic Resource
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