Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Relative probability of mutagenic translesion synthesis on the leading and lagging strands during replication of UV-irradiated DNA in a human cell extract (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 11476-11482 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00094a002
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Benchmark Analysis: Shopping with Proper Confidence (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Risk analysis 25 (2005), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.2005.00636.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Concordance of Carcinogenic Response between Rodent Species: Potency Dependence and Potential Underestimation (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 12 (1992), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The use of average qualitative concordance between two bioassay endpoints is considered, with emphasis directed at agreement between rats and mice from results of long-term carcinogenicity studies. It is noted that concordance varies as a function of the underlying potency or toxicity of the chemicals over which the averaging is performed. Thus, the averaging process dilutes large observed concordances from potent chemicals, and possibly inflates lower observed concordances from weakly active chemicals. Stratification over some measure of potency is suggested as a method for taking these effects into account. Statistical simulations of concordance analyses limited to low-potency ranges are employed to examine the concordance measure in greater detail. It is seen that at low potencies, observed concordance is consistently underestimated, reaching maximum levels of only about 80%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1992.tb01314.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Vulnerability of U.S. Cities to Environmental Hazards (2007)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Journal of homeland security and emergency management 4 (2007), S. 5 
    Details
    ISSN: 1547-7355
    Source: Berkeley Electronic Press Academic Journals
    Topics: Political Science , Sociology
    Notes: As cities continue to increase in size, population diversity, and complexity their vulnerability to future disasters will increase as well. This paper explores the variability in vulnerability to natural hazards among the 132 urban areas using three indices of vulnerability: social, built environment, and hazard impact. The paper then examines the relative levels of vulnerability compared to federal UASI funding. The paper demonstrates that vulnerability manifests itself as a place-based regional phenomenon, with the most vulnerable cities located in the eastern half of the U.S. The relative importance of the underlying correlates changes from city to city across the United States with social vulnerability assuming greater importance in the South and Southwest, and built environment vulnerability showing regional primacy as the driving indicator among Northeastern and Midwestern cities. Based on this empirical analysis, New Orleans was the most vulnerable urban area in the U.S. yet received only one percent of the preparedness resources awarded by the federal government.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/jhsem/vol4/iss2/5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    facet.materialart.
    Unknown
    The Gregor Mendel Controversy: Early Issues of Goodness-of-fit and Recent Issues of Genetic Linkage (1986)
    Cambridge : Periodicals Archive Online (PAO)
    History of science. 24:2=64 (1986:June) 173-182 
    Details
    ISSN: 0073-2753
    Topics: History , Natural Sciences in General
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:e363-1986-024-02-000004
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Discussion (1995)
    Springer
    Environmental and ecological statistics 2 (1995), S. 78-79 
    Details
    ISSN: 1573-3009
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452933
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Empirical Bayes calculations of concordance between endpoints in environmental toxicity experiments (1994)
    Springer
    Environmental and ecological statistics 1 (1994), S. 153-162 
    Details
    ISSN: 1573-3009
    Keywords: agreement ; confidence intervals ; dichotomous data ; environmental carcinogenesis ; generalized linear models ; hierarchical models ; logistic regression ; parametric empirical Bayes methods ; potency ; shrinkage estimator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Hierarchical models are considered for estimating the probability of agreement between two outcomes or endpoints from an environmental toxicity experiment. Emphasis is placed on generalized regression models, under which the prior mean is related to a linear combination of explanatory variables via a monotone function. This function defines the scale over which the systematic effects are modelled as additive. Specific illustration is provided for the logistic link function. The hierarchical model employs a conjugate beta prior that leads to parametric empirical Bayes estimators of the individual agreement parameters. An example from environmental carcinogenesis illustrates the methods, with motivation derived from estimation of the concordance between two species carcinogenicity outcomes. Based on a large database of carcinogenicity studies, the inter-species concordance is seen to be reasonably informative, i.e. in the range 67–84%. Stratification into pertinent potency-related sub-groups via the logistic model is seen to improve concordance estimation: for environmental stimuli at the extremes of the potency spectrum, concordance can reach well above 90%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02426659
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Optimal design allocations for estimating area under curves for studies employing destructive sampling (1989)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 17 (1989), S. 493-507 
    Details
    ISSN: 1573-8744
    Keywords: mean squared error ; mean absolute deviation ; nonlinear experimental design ; numerical quadrature ; trapezoidal rule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Optimal allocations of experimental resources for the estimation of integrals is considered for experiments that use destructive sampling. Given a set of sampling times, a minimum mean square error rule is given for the allotment of fixed experimental resources to the independent variable. The results are seen to be functionally dependent upon the pattern of underlying variability assumed in the model and upon the quadrature rule used to estimate the integral. Extensions to other optimality criteria, including a minimum mean absolute deviation criterion, and to cases involving multiple treatment groups, are also noted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061459
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...