ISSN:
1573-2568
Schlagwort(e):
CROHN'S DISEASE
;
LYMPHADENITIS
;
ABSCESS
;
SWEET'S SYNDROME
;
STEROIDS
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Our purpose is to describe seven cases ofdisseminated aseptic abscesses with regard to clinical,biological, radiological, and histological information,treatment, and outcome. Data were collected on seven Caucasian patients who had proven sterile deepabscesses diagnosed in French university hospitals. Theonset of the disease related to abscesses began at timesfrom June 1988 to August 1994. Follow-up periods were 1 year, 7 months to 8 years, 2 months. Theage of the patients ranged from 15 to 26 years old. Atonset, all had fever and six had abdominal pain.Abscesses involved spleen and abdominal lymph nodes in six cases; liver in three; pancreas, brain,and chest in one. All had polymorphonuclearleukocytosis. Pathological examination showedgranulomatous abscesses. Direct and indirectinvestigations failed to identify any causal microorganism. On sixoccasions, Crohn's disease was revealed 1 to 41 monthslater and in one case, it preceded the onset ofabscesses. One subsequently developed Sweet's syndrome. Various antibiotic regimes were inefficient.Steroids, associated in three cases withimmunosuppressive agents, resulted in a rapidimprovement in six patients. In one case, splenectomyfollowed by 5-ASA therapy was used successfully. The dramaticeffectiveness of steroids and immunosuppressive agentsas well as follow-up suggest that disseminated asepticabscesses might be an extraintestinal manifestation of Crohn's disease. Although the pathogenesisof this condition remains unknown, this entity may berelated to neutrophilic dermatosis in which sterile deepabscesses have been reported.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1018835228850
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