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  • 1
    Electronic Resource
    Electronic Resource
    The influence of administered mass on the subcellular distribution and binding of mercury in rat liver and kidney (1985)
    Springer
    Archives of toxicology 56 (1985), S. 242-246 
    Details
    ISSN: 1432-0738
    Keywords: Mercury ; Metallothionein ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of the administered mass on the tissue and sub-cellular distribution of mercury (Hg) was investigated in rats, using 203Hg. The fraction of the dose deposited in liver increased threefold over the dose range 0.17–1.65 mg Hg · kg−1, while the retention in the kidney decreased by a factor of 2. The uptake in other organs, lung, spleen, brain, thymus, salivary glands showed no dose-dependent variation. Subcellular fractionation studies showed a dose-dependent increase in the Hg content of the liver cytosol, with corresponding decreases in the deposition in the lysosomal and nuclei-cell debris fractions. In contrast, no clear changes in the distribution of Hg amongst the subcellular organelles of the kidney were observed. The amount of Hg bound to metallothionein in the liver cytosol rose steeply with increasing dose. However, in the kidney cytosol the mass of Hg bound to metallothionein increased with dose up to 0.55 mg Hg · kg−1, thereafter remaining approximately constant. These observations suggest that the Hg-binding metallothionein in the kidney was saturated by administered doses greater than 0.55 mg Hg · kg−1, whereas in liver saturation levels of the metal were not reached even at the highest dose tested, 1.65 mg Hg · kg−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295161
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  • 2
    Electronic Resource
    Electronic Resource
    The role of a metal-transferrin-transferrin-receptor mechanism if the in vitro uptake of metals by human lymphoblasts (WIL-2)
    Amsterdam : Elsevier
    Inorganica Chimica Acta 79 (1983), S. 223-224 
    Details
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0020-1693(00)95260-5
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemical studies of the interactions of plutonium, neptunium and protactinium with blood and liver cell proteins
    Amsterdam : Elsevier
    Inorganica Chimica Acta 140 (1987), S. 361-363 
    Details
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0020-1693(00)81124-X
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Beeinflussung der renalen Exkretion von D-Penicillamin bei der Ratte (1974)
    Springer
    Research in experimental medicine 163 (1974), S. 39-45 
    Details
    ISSN: 1433-8580
    Keywords: D-penicillamine ; Acetazolamide ; Renal excretion ; Rat ; D-Penicillamin ; Acetazolamid ; Renale Exkretion ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die renale Ausscheidung von D-Penicillamin läßt sich weder durch Probenecid noch durch N-Methylnicotinamid oder NH4Cl beeinflussen. Acetazolamid bewirkt eine erhöhte Retention von D-Penicillamin in Haut und Muskulatur und hemmt dessen renale Ausscheidung, hat jedoch keinen Effekt auf die Dekorporationswirksamkeit von D-Penicillamin bei60Co. Die möglichen Ursachen des Einflusses von Acetazolamid auf die Verteilung und Exkretion von D-Penicillamin werden diskutiert.
    Notes: Summary The renal excretion of D-penicillamine is not influenced by probenecid, N-methylnicotinamide, and NH4Cl. Acetazolamide brings about an increased retention of D-penicillamine in skin and muscles and lowers its urinary excretion, but does not exhibit any influence on the efficacy of D-penicillamine in removing internally deposited60Co. The possible causes for the action of acetazolamide on the distribution and excretion of D-penicillamine are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851444
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  • 5
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Bildung gemischter Disulfide zwischen D-Penicillamin und Serumproteinen (1973)
    Springer
    Research in experimental medicine 161 (1973), S. 289-297 
    Details
    ISSN: 1433-8580
    Keywords: D-penicillamine ; L-cysteine ; Serum proteins ; Rat ; D-Penicillamin ; L-Cystein ; Serumproteine ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vitro-Untersuchungen zeigten, daß D-Penicillamin durch Serumproteine, in erster Linie durch Albumin, gebunden wird. Aller Wahrscheinlichkeit nach ist die Bildung gemischter Disulfide hierfür verantwortlich. Cystin, L-Cystein und andere Thiole sowie N-Äthylmaleinimid hemmen die Proteinbindung von D-Penicillamin. Verabfolgt man Ratten vor Injektion des D-Penicillamins L-Cystein, resultiert eine vorübergehende Erhöhung des Gehalts an freiem D-Penicillamin in Serum und in einigen Geweben, während die Ausscheidung mit dem Urin verzögert wird. Die theoretische und praktische Bedeutung der Befunde wird diskutiert.
    Notes: Summary Studiesin vitro show that D-penicillamine is bound by serum proteins, mainly albumin; the formation of a mixed disulfide is the most likely explanation. Cystine, L-cysteine and other thiols as well as N-ethylmaleinimide were found to inhibit the protein binding of D-penicillamine. Administration of L-cysteine to rats prior to D-penicillamine brings about a transient increase of the amount of free D-penicillamine in serum and in some tissues as well as a delay in its urinary excretion. The theoretical and practical implications of the findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851452
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  • 6
    Electronic Resource
    Electronic Resource
    Compartmental study on the pharmacokinetics of D-penicillamine (1973)
    Springer
    Radiation and environmental biophysics 10 (1973), S. 321-336 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary An eight-compartment model was developed for the pharmacokinetics of D-penicillamine. The analysis shows that a simpler model, based on the assumption of one chemical form of penicillamine only, fails and that the concept of two different forms of penicillamine must be introduced. Most probably, it concerns the disulfide of penicillamine and its mixed disulfide with cysteine. The primary distribution volume for both compounds is the extracellular fluid. Binding to plasma proteins has no essential effect on the overall kinetics. The two disulfides are handled by the kidneys in a different manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194227
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  • 7
    Electronic Resource
    Electronic Resource
    Recommendations for testing new chelating agents for removal of incorporated actinides from the body (1982)
    Springer
    Radiation and environmental biophysics 21 (1982), S. 45-50 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The body content of certain radionuclides and the consequences of accidental incorporation may be reduced by treatment with chelating agents. Such agents have been widely studied and have proved to be useful in man. Chelation therapy may also be advantageous in certain cases of heavy metal poisoning. There is still a need to develop new, more efficient and less toxic agents and better therapeutic schedules for using the existing agents. So far as possible the testing of potential new compounds should be carried out using standardized methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01338754
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