ISSN:
1573-8221
Keywords:
nitroso compounds
;
transplacental carcinogenesis
;
organ cultures
;
embryonic liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The transplacental and direct action of nitrosomethylurea on organ cultures of the liver from 18–20-day CBA and C57BL mouse embryos and of diethylnitrosamine on liver cultures from noninbred rat embryos was studied. The nitroso compounds accelerated adaptation of the explants, increased the viability of the cultures compared with normal, and led to hyperplastic proliferation of the small basophilic cells whose survival rate under both normal and experimental conditions was higher than that of ordinary embryonic hepatocytes. The growth-stimulating effect depended on the object (species, line of animals) and the factor to which it was exposed (carcinogen, mode of administration).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00830367
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