ISSN:
1573-8221
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Polysaccharides glucan and laminarin produce a practically identical preventive effect in experimental staphylococcic sepsis and secure the survival of 76–83% of mice, whereas in control experiments the death rate is 90%. Substantial differences have been revealed in the action of these preparations in sepsis caused by gram-negative microorganisms (E coli.,B. typhi abdominalis,Proteus mirabilis). Glucan in a dose of 20 mg/kg infected intraperitoneally averted the death of animals, whereas laminarin in the same dose proved ineffective. Glucan injected intraperitoneally or intravenously in a dose of 20 mg/kg produced a pronounced antitumor effect against Ehrlich's turmor and sarcoma 180, inhibiting the tumor growth by 53–60%. No inhibitory activity of laminarin with regard to S-180 and Ehrlich's tumor was found under analoguous conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01892452
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