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  • 1
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 19 (1986), S. 362-363 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 25 (1953), S. 322-331 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 1 (1996), S. 57-66 
    ISSN: 1432-0517
    Keywords: Key words Traceability ; Demonstrable ; Uncertainty ; Total ; Accuracy ; Chemical ; analysis ; Quantitative ; Reference materials ; Reference measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  National measurement systems are infrastructures to ensure, for each nation, a consistent and internationally recognised basis for measurement. Such complex systems have historical, technical, legal, organisational and institutional aspects to connect scientific metrology with practical measurements. Underlying any valid measurement is a chain of comparisons linking the measurement to an accepted standard. The ways the links are forged and the etalons (measurement standards) to which they connect are defining characteristics of all measurement systems. This is often referred to as traceability which aims at basing measurements in common measurement units – a key issue for the integration of quantitative chemical analysis with the evolving physical and engineering measurement systems. Adequate traceability and metrological control make possible new technical capabilities and new levels of quality assurance and confidence by users in the accuracy and integrity of quantitative analytical results. Traceability for chemical measurements is difficult to achieve and harder to demonstrate. The supply of appropriate etalons is critical to the development of metrology systems for chemical analysis. An approach is suggested that involves the development of networks of specialised reference laboratories able to make matrix-independent reference measurements on submitted samples, which may then be used as reference materials by an originating laboratory using its practical measurement procedures.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 1 (1996), S. 150-159 
    ISSN: 1432-0517
    Keywords: Key words Traceability ; Analysis ; Legal ; Metrology ; Reference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  Economic and technological change, regional and international trade and the globalisation of industry have led to intense pressures for improvements to analytical quality, reliability and comparability. Of central importance are national traceability structures connecting chemical measurements in the field with internationally accepted measurement units and their practical realisations. Australia has a developed physical and engineering measurement system, a legislative framework for analytical traceability and, in the National Association of Testing Authorities, a recognised laboratory accreditation system. The need has been identified to develop the technical capability to perform matrix-independent reference measurements for the certification of traceable reference materials, useable as practical analytical etalons to establish metrological control systems in field measurements for amounts of substance. Recently, a unique collaborative consortium has proposed a National Analytical Reference Laboratory (NARL). The NARL is designed to be a metrological mass spectrometry facility for the transference of measurement units to more widely useable chemical measurement standards and reference materials.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 3 (1998), S. 82-83 
    ISSN: 1432-0517
    Keywords: Key words Measurement system ; Practical metrology ; Chemical analysis ; Traceability ; Quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  The Analytical Division of the Royal Australian Chemical Institute (RACI) held its 14th biennial symposium on analytical chemistry (14AC) in Adelaide, South Australia on 5–9 July 1997 [1]. The theme, "A broader view of the world" was an explicit invitation from the organisers to analysts to "take time away from their laboratories and consider how their work affects the world . . . A major challenge to chemists is to redefine their role in industry, education and the community and face, head-on, the demands brought about by free trade, economic rationalism and the environment." Part of this challenge, as reflected in invited plenary and keynote speakers as well as the cut and thrust of debate on the conference floor, is to address the important role of chemical measurement and confidence in the domestic and international systems of measurement.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1041
    Keywords: Monoamine oxidase type B ; Positron emission tomography ; Ro 19-6327 ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight normal subjects (3 females and 5 males) were studied using intravenous L-11C] deprenyl and positron emission tomography. In a single blind study one subject received tracer alone, one subject received an oral pre-dose of 20 mg of L-deprenyl and 6 subjects received oral pre-doses of 10 to 50 mg of a novel reversible MAO-B inhibitor (Ro 19-6327). Dynamic PET scans beginning 12 h after the oral dose were collected over 90 min and arterial blood was continuously sampled. Data analysis was modelled for two tissue compartments and using an iterative curve fitting technique the value of the rate constant for irreversible binding of L-[11C] deprenyl to MAO-B (k3) in whole brain was obtained for each subject. The dose response curves obtained indicated that a dose of at least 0.48 mg·kg−1 of Ro 19-6327 was necessary for 〉90% decrease in whole brain k3. Inhibition of MAO-B in platelets isolated from blood samples taken at the time of scanning correlated strongly with decrease in whole brain k3 (r=0.949). The results indicate that PET can be used to determine the dose of Ro 19-6327 necessary to inhibit 〉90% of brain MAO-B. This technique is an attractive alternative to traditional large scale patient-based dose-finding studies. Moreover it is shown that inhibition of platelet MAO-B can be used as a marker for central MAO-B inhibition with Ro 19-6327.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 3120-3122 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A relatively simple and inexpensive specimen-exchange system for molecular beam epitaxy or other similar UHV applications is described. It allows 12 samples to be simultaneously loaded and degassed in UHV.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 548-557 
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Using theoretical simulations based on density functional theory within the generalized gradient approximation, a series of metastable phase transitions occurring in low-pressure Al2SiO5 polymorphs (andalusite and sillimanite) are predicted; similar results were obtained using semiclassical interatomic potentials within the ionic shell model. Soft lattice modes as well as related structural changes are analysed. For sillimanite, an isosymmetric phase transition at ca 35 GPa is predicted; an incommensurately modulated form of sillimanite can also be obtained at low temperatures and high pressures. The high-pressure isosymmetric phase contains five-coordinate Si and Al atoms. The origin of the fivefold coordination is discussed in detail. Andalusite was found to transform directly into an amorphous phase at ca 50 GPa. This study provides an insight into the nature of metastable modifications of crystal structures and the ways in which they are formed. Present results indicate the existence of a critical bonding distance, above which interatomic interactions cannot be considered as bonding. The critical distance for the Si—O bond is 2.25 Å.
    Type of Medium: Electronic Resource
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