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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the prognostic significance of presentation serum albumin, clinical stage and CA125 levels in ovarian cancer.Design Retrospective analysis of data using a Cox proportional hazards model.Setting A district general hospital oncology unit.Subject One hundred and fourteen consecutive patients with epithelial ovarian cancer.Interventions Cytotoxic chemotherapy and surgery.Main outcome measure Survival.Results A linear increase in risk was observed with high log CA125 (P 〈 0.0001) and with low albumin (P 〈 0.0001). In late stage patients (III and IV) albumin is the best predictor of survival (P= 0.0006). The presence of ascites, blood transfusion, type of surgery or chemotherapy did not improve the predictive model.Conclusions CA125 and albumin can be used to identify prognostic subgroups independently of stage. Albumin alone can also be used as a predictor of survival. A simple classification of patients into three groups based on serum albumin of 41 g/l or more, 35 to 40 g/l and 34 g/l or less provides a clear separation of survival curves in the present group of patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 2452-2454 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: High-purity silica that contains a high concentration of dissolved molecular hydrogen is found to undergo expansion, rather than densification, as a consequence of exposure to deep ultraviolet irradiation. Concurrent with the decreased density, we suggest that a positive photorefractive effect occurs, which increases the index. The contributions of the density change and the photorefractive effect can be observed by comparison of the birefringence and the wave front change obtained through interferometry. Expansion and the photorefractive effect are interpreted in terms of the photolytic formation of SiOH. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 219-221 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have used linearly polarized 193-nm-excimer laser irradiation to create polarization-induced birefringence in silica. We have observed the polarization-induced birefringence irrespective of whether the sample undergoes net compaction or expansion. The sign of the birefringence is dependent on whether the glass is expanding or compacting. It is suggested that the birefringence derives from an anisotropic density change effected by the linearly polarized exposure. This effect can be expressed formally as an optical frequency-induced dc electrostriction. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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